Vol 362, Issue 6418
This Week in Science
Products & Materials
Books et al.
- Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation
The structure of the yeast 26S proteasome reveals sequential states of ATP binding, hydrolysis, and substrate translocation.
A mycobacterial respiratory supercomplex forgoes soluble electron carriers and associates with superoxide dismutase.
Microstructural plasticity in human brains shows the rapid emergence and long-term persistence of neocortical memory storage.
- The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago
The Nwya Devu Paleolithic site in Tibet, 4600 meters above sea level, preserves evidence of early human high-altitude adaptation.
Many mucosal melanomas show loss or inactivation of SPRED1, a gene encoding a negative regulator of RAS/MAPK signaling.
A multiomics approach reconstructs genetic lineages and epigenomic and transcriptomic dynamics of patient-derived disseminating tumors.