Contents
29 November 2019
Vol 366, Issue 6469
Vol 366, Issue 6469
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Bacteria-armed mosquitoes make dent in dengue
Field trials suggest spreading Wolbachia could reduce cases of debilitating viruses.
- Universities move to stop passing the harasser
Changes in hiring practices ask job candidates to allow employers to disclose findings.
- U.K. parties stake out science stances in ‘Brexit election’
Contenders' Brexit policies are starkly different.
- Questions churn about vaping's long-term risks
Studies in people and animals explore potential chronic harms to the heart and lungs.
- Top Chinese scientist faces questions about publications
Case seen as a test of China's efforts to improve research integrity and crack down on scientific misconduct.
- European Mars rover in a ‘race against time’ to fix parachutes
ExoMars team looks to NASA for help after unexplained parachute tears.
Feature
- A shot of hope
The first malaria vaccine is finally being rolled out—despite limited efficacy and nagging safety concerns.
Working Life
Letters
Books et al.
- The pursuit of Earth's waters
A historian shares stories of six scientists who laid foundations for modern climate science
- Arbiters of truth, then and now
A 40-year-old tome's prescient observations about scientific fact-making resonate today
Policy Forum
- Cyber risk research impeded by disciplinary barriers
Security progress requires cross-disciplinary collaboration
Perspectives
- A chemical path to quantum information
Nanoscale graphene can be designed to function as a molecular qubit
- Regulation of negative emotional behavior
A lower-brainstem structure regulates a psychobehavioral state for avoidance behavior
- An unexpected cofactor
A mystery of bacterial chromosome segregation is explained by a nucleotide cofactor
- Immunology taught by vaccines
Systems analysis of vaccine responses reveals the impact of the microbiota on human immunity
- Illuminating Earth's faults
Submarine fiber-optic cables drive discovery of fault locations and ocean dynamics
- Immunostimulatory gut bacteria
Some bacterial species stimulate inflammation, autoimmunity, and anticancer immunity
- Surface nanopatterning with polymer brushes
A variety of surfaces are patterned with precisely defined cylindrical micelles
Association Affairs
- Indoor chemical pollution impacts often remain invisible
AAAS Research Competitiveness symposium shows need for transdisciplinary collaboration
Research Articles
- Dense connectomic reconstruction in layer 4 of the somatosensory cortex
An advanced, automated imaging and analysis tool reconstructs high-resolution morphological features of 89 neurons and their connections.
- Median raphe controls acquisition of negative experience in the mouse
A potential computational hub in the brainstem involved in signaling aversive experiences is identified.
Reports
- Tailored multifunctional micellar brushes via crystallization-driven growth from a surface
A platform for making diverse, tunable surfaces has been built using micellar block copolymers.
- Incoherent strange metal sharply bounded by a critical doping in Bi2212
Angle-resolved photoemission indicates a temperature-independent boundary between the strange metal and conventional phases.
- Illuminating seafloor faults and ocean dynamics with dark fiber distributed acoustic sensing
Ocean and seafloor dynamics can be monitored using preexisting optical cables on the seafloor.
- Quantum units from the topological engineering of molecular graphenoids
Enhanced quantum performance has been realized in building blocks of nanoengineered graphene.
- Direct observation of bimolecular reactions of ultracold KRb molecules
Cooling molecules down close to zero kelvin enables observation of a four-atom intermediate in a diatomic metathesis reaction.
- Fatigue-resistant high-performance elastocaloric materials made by additive manufacturing
The microstructure of elastocaloric metals created by laser melting promotes fatigue resistance.
- Mutual control of coherent spin waves and magnetic domain walls in a magnonic device
Domain walls shift the phase and magnitude of spin waves in Co/Ni multilayer films.
- Magnetization switching by magnon-mediated spin torque through an antiferromagnetic insulator
Magnon currents are used to switch the magnetization of an adjacent ferromagnetic layer.
- Self-organization of parS centromeres by the ParB CTP hydrolase
The bacterial ParB protein is a cytidine triphosphate phosphohydrolase involved in chromosome organization.
- Brain cell type–specific enhancer–promoter interactome maps and disease-risk association
Cell type–specific regulatory elements in the human brain reveal noncoding variants associated with neurological diseases.
- Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
Detailed mutagenesis analysis reveals how sequence changes affect adeno-associated virus delivery properties in vivo and in vitro.
- Lactose drives Enterococcus expansion to promote graft-versus-host disease
Enterococcus outgrowth increases graft-versus-host disease risk in patients.
- Watching helical membrane proteins fold reveals a common N-to-C-terminal folding pathway
Single-molecule experiments reveal that translation, insertion, and folding can be coupled during membrane protein biogenesis.
Technical Comments
About The Cover
COVER Nerve cells from the mouse brain, densely reconstructed in this volume. For a century, neuron reconstruction in the cerebral cortex showed only ~1 in 1000 nerve cells (black); now researchers can use 3D electron microscopy and AI-based image analysis to reconstruct all of them (gray). The connectivity matrix between thousands of axons and dendrites can be measured, yielding insights about the formational patterns of brain circuits and possible imprints of learning in the neuronal network. See page eaay3134.
Image: V. Altounian/Science; Data: A. Motta et al., Science 366, eaay3134 (2019)
