Subject: PLOS Genetics Volume 15(12) December 2019 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: 8bit

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New Articles in PLOS Genetics

PUBLISHED: December 01, 2019 to December 31, 2019

Topic Page

Architecture of the Escherichia coli nucleoid

Research Articles

A mutant form of Dmc1 that bypasses the requirement for accessory protein Mei5-Sae3 reveals independent activities of Mei5-Sae3 and Rad51 in Dmc1 filament stability

Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway

The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain

An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior

Modulators of hormonal response regulate temporal fate specification in the Drosophila brain

Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21

Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization

Leveraging allelic imbalance to refine fine-mapping for eQTL studies

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

Hybridization promotes asexual reproduction in Caenorhabditis nematodes

Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children

APOBEC3A is a prominent cytidine deaminase in breast cancer

zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage

Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1

A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival

Identification of novel genes involved in phosphate accumulation in Lotus japonicus through Genome Wide Association mapping of root system architecture and anion content

Latent transcriptional variations of individual Plasmodium falciparum uncovered by single-cell RNA-seq and fluorescence imaging

Experimental population modification of the malaria vector mosquito, Anopheles stephensi

Common gardens in teosintes reveal the establishment of a syndrome of adaptation to altitude

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes

Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity

Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII

Phosphatidylserine synthetase regulates cellular homeostasis through distinct metabolic mechanisms

Genetic determinants of genus'Level glycan diversity in a bacterial protein glycosylation system

BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana

Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy

CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4

Cell elimination strategies upon identity switch via modulation of apterous in Drosophila wing disc

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

Common alleles of CMT2 and NRPE1 are major determinants of CHH methylation variation in Arabidopsis thaliana

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance

Identification of avoidance genes through neural pathway-specific forward optogenetics

Corrections

Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

Correction: Origins of DNA replication

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