Subject: PLOS Biology Volume 16(11) November 2018 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: 8bit


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New Articles in PLOS Biology

PUBLISHED: November 01, 2018 to November 30, 2018

Community Pages

The NIH BRAIN Initiative: Advancing neurotechnologies, integrating disciplines

This Community Page article describes how the National Institutes of Health BRAIN Initiative offers an unprecedented opportunity to accelerate the development and application of new technologies to enable researchers to produce dynamic pictures of the brain, showing how individual cells and complex circuits interact in real time.

Building a local community of practice in scientific programming for life scientists

Vibrant symbiosis: Achieving reciprocal science outreach through biological art

This Community Page article presents an alternative outreach model that prioritizes building a reciprocal relationship between scientists and outsiders, describes an example involving college students and adult artists with intellectual and developmental disabilities working together to create BioArt, and discusses how others can cultivate similar opportunities within their local communities.

Meta-Research Article

Reproducible research practices, transparency, and open access data in the biomedical literature, 2015'2017

Comparison of the biomedical literature 2015-2017 with an earlier study (2000-2014) suggests that although there have been recent improvements in the reproducibility and transparency of the published record, opportunities for improvement exist.

Research Articles

Spatiotemporal coordination of cell division and growth during organ morphogenesis

A combination of computational modelling and live imaging shows how leaves form through dual spatiotemporal control of growth and cell division, with cross-connections between them.

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

Bioinformatic analysis and experiments on clinical samples and mouse models of breast cancer unveil a new signaling protein degradation pathway involving TRIM59 and PDCD10 that modulates breast cancer cell growth, survival, and metastasis.

Spore-autonomous fluorescent protein expression identifies meiotic chromosome mis-segregation as the principal cause of hybrid sterility in yeast

Low levels of genome sequence divergence can keep yeast populations reproductively isolated by interfering with the segregation of chromosomes during gamete production in hybrids, thereby resulting in hybrid sterility.

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

The epigenetic trimethyl modification H3K36m3, mediated by the histone methyltransferase Setd2, determines bone marrow mesenchymal stem cell fate partially through the regulation of lipopolysaccharide-binding protein, Lbp.

Intramembrane ionic protein'lipid interaction regulates integrin structure and function

Calcium regulates the structure and function of integrin by disrupting an interaction between a "snorkeling" basic amino acid and an acidic phospholipid within the membrane.

Gut microbiome transition across a lifestyle gradient in Himalaya

Gut microbiome profiles from human Himalayan populations practicing diverse subsistence strategies show that colonic microbial communities change as humans shift away from foraging.

Heterologous Hsp90 promotes phenotypic diversity through network evolution

Yeast cells carrying the heat shock protein Hsp90 from a distant species exhibit increased potential to evolve divergent phenotypes after propagating under a normal growth condition for thousands of generations.

Identification of molecular determinants that govern distinct STIM2 activation dynamics

A protein engineering approach delineates how two STIM homologs, STIM1 and STIM2, differentially sense and respond to calcium signals, overcome intramolecular autoinhibition, and trigger calcium influxes into mammalian cells.

Evolution of correlated complexity in the radically different courtship signals of birds-of-paradise

New approaches to measuring the complexity of acoustic, behavioral, and color ornaments reveal correlated evolution of signals in birds-of-paradise, suggesting functional integration of ornamental traits into a composite unit.

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

A comparison of Hox gene regulation during the development of limbs in birds and mammals reveals that whereas the characteristic bimodal regulatory system, based on large chromatin domains, is largely conserved between these morphologically distinct structures, some differences are revealed in the way this is implemented in various vertebrates.

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

Adolescent development of cortical oscillations: Power, phase, and support of cognitive maturation

Short Reports

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

Pyroptosis mediated by the pore-forming protein gasdermin D plays a crucial role in the pathogenesis of neonatal-onset multisystem inflammatory disease, a severe genetic autoinflammatory disorder resulting from activating mutations in the NLRP3/cryopyrin gene.

Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex

Cryo-electron tomography of periplasmic flagella in the Lyme disease bacterium Borrelia burgdorferi reveals it to have a distinct cytoplasmic ATPase complex and an atypical interaction with the flagellar C-ring.

JMJD5 links CRY1 function and proteasomal degradation

Methods and Resources

Harnessing olfactory bulb oscillations to perform fully brain-based sleep-scoring and real-time monitoring of anaesthesia depth

Gamma oscillations in the olfactory bulb track changes in vigilance states with remarkable precision, allowing the development of a novel fully brain-based sleep-scoring methodology and real-time monitoring of depth of anaesthesia.

Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation

Comprehensive CRISPR-Cas9-mediated genome-wide screens for resistance to Shiga toxins and Ricin reveal novel Golgi proteins critical for glycolipid synthesis and regulation of glycosylation levels.

Formal Comments

Biodiversity assessments: Origin matters

This Formal Comment acknowledges that more comprehensive assessments of global biodiversity including native and non-native species are needed, but maintains that we must resist the temptation to oversimplify the concept of biodiversity.

On the importance of monitoring and valuing all forms of biodiversity

Pauchard et al claim that non-native species should not be granted conservation value, as this could hinder effort to curtail novel introductions. In this response, Schlaepfer counters that the positive contributions of non-native species to biodiversity and conservation must be included to provide a complete and objective snapshot to policy makers.


Correction: Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly


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