September 2017 marks the 60th anniversary of one of the most significant lectures in the history of biology. This essay explores the rich content of Francis Crick's 1957 ˜central dogma' lecture and its continuing power to help us think about how genes work.
This Community Page article describes the Experimental Design Assistant, a free-to-use web-based tool which helps in vivo researchers plan their experiments and provides feedback to improve the experimental design and analysis plans.
"Spin," commonly associated with propaganda, is also present in published biomedical research. This systematic review shows that the nature of spin varies with study design, with the highest prevalence in clinical trials.
This study uses large biomedical datasets (UK BioBank, GERA) to directly observe natural selection in contemporary humans; a new approach identifies genetic variants with effects on age-specific mortality.
Contrary to conventional wisdom, direct active marine restoration can be the most cost-effective way to maximise the extent of coastal marine ecosystems ' such as seagrass ' over decade time-scales.
An optogenetic study in rats reveals how the hippocampal place cell network integrates spatial information and context reward value, enabling episodic memory for past experience to support future adaptive behavior.
Reduced insulin signaling can improve function and increase lifespan in a number of species. This study, combining imaging, in vivo electrophysiology and cell culture, demonstrates that attenuated insulin signaling has beneficial effects on the functioning of a neuronal circuit in aging Drosophila.
A study of rats explores how factors such as sexual experience influence the development of genital cortex and how genital cortex growth affects female sexual maturation.
Structural, logic-based, and experimental analysis of a plant signal transduction network regulating stomatal closure predicts a previously unrecognized feedback mechanism involving cytosolic calcium ions.
A modelling study finds that kinematic expression waves of the pair-rule gene even-skipped are crucial for segment patterning in Drosophila, suggesting that key aspects of long-germ segmentation are inherited from short-germ ancestors.
Transcriptomic analysis of head and neck cancer cells reveals alternative splicing of EIF2B5 as a previously uncharacterized mechanism of translational control under conditions of hypoxia.
Methods and Resources
Transcription start-site profiling of the chick from freshly laid egg to the moment of hatching reveals dynamic changes in genome-wide promoter usage during avian embryogenesis.
A new comparative genome study of Blastocystis, a parasite commonly found in the human gut, uncovers high levels of differences between Blastocystis subtypes and provides a resource for future investigations.
A live-cell imaging study maps the dynamics of core cell-cycle regulators and reveals unexpected dynamics for several proteins in actively proliferating versus spontaneously quiescent cells.
A genome-wide barcoded transposon mutagenesis study in a root-colonizing strain of the bacterium Pseudomonas
simiae revealed over a hundred
genes that significantly impacted the ability to competitively colonize roots
of the plant Arabidopsis thaliana.
This Formal Comment points out the major challenges that exist for experimental design and neural signal analysis when researchers set out to study deceptively simple human percepts such as ˜rhythm.' Read the associated Research Article here.
This response to an accompanying Formal Comment delineates the experimental design and computational models necessary for overcoming the ambiguity in the concept of "rhythm", and identifying the neural signatures of oscillatory entrainment to streams. Read the associated Research Article here.