This Primer examines recent research that identifies utility as a useful notion to formalize how effort is subjectively perceived in the context of cost-benefit analyses for movement control and for decisions between movements. Read the related Research Article here.
The modern scientific era offers the perfect opportunity to merge traditional (morphological) taxonomy with cutting-edge "Omics" approaches. Incorporating (rather than discarding) such historical knowledge could transform the way biological studies are conducted in the future.
It's rare for international funders to work together but the Open Science Prize brought three funders ' The National Institutes of Health, The Wellcome Trust and The Howard Hughes Medical Institute ' to do just that.
The Genomic Observatories Metadatabase (GeOMe-db.org) is an open access repository for the geospatial and environmental metadata directly associated with genetic data, essential to scientific reproducibility and synthesis.
Given the importance of antibiotics to modern medicine, and the growing apprehension surrounding the threat of resistance, this Open Highlight looks at the cellular mechanisms of antibiotic resistance, the evolution and spread of resistance, and techniques for combating resistance. Browse the related collection here.
A comprehensive profile of lncRNA transcriptome changes during white fat browning and brown fat activation identifies lncBATE10 as a novel regulator of these biological processes.
The beneficial effects of reduced nutrient intake on enhancement of learning are not just secondary consequences of extended lifespan but are specifically due to depletion of the tryptophan metabolite (and glutamatergic antagonist) kynurenic acid.
Many bacteria move using a complex, self-assembling nanomachine, the bacterial flagellum. This study reveals that an integral-membrane chaperone, FliO, coordinates the self-assembly of the multi-component type III secretion system needed to export the building blocks of the bacterial flagellum.
Structural and functional analyses of the core structure of the bacterial flagellar type III export gate complex reveal novel insights into how the gate complex is formed inside the flagellar basal body MS ring.
The Epstein Barr virus transcription factors EBNA3A and EBNA3C play a vital role in establishing viral latency in memory B cells, by epigenetically suppressing the transcription program that drives the B cell-to-plasma cell differentiation pathway.
The karyopherin-2 nuclear import system regulates the targeting of the Hedgehog signaling pathway transcription factor Gli to the primary cilium, and forms a positive feedback loop.
A study of the human bacterial pathogen Pseudomonas aeruginosa shows that different adaptation histories to antibiotics lead to distinct evolutionary dynamics of multidrug resistance, potentially informing the design of strategies to mitigate resistance and combat bacterial infections.
A comparative study of the pathogenic fungus Cryptococcus shows that chromosomal rearrangements involving centromeric regions played important roles in the evolution of fungal genomes, including the transition between different mating systems.
Cardiomyocyte t-tubule microfolds containing the membrane deformation protein cBIN1 recruit an ESCRT-III component to snip off and release cBIN1-containing microparticles. The released cBIN1 can be measured in blood as a marker of myocardial health.
During B cell receptor activation, the mTORC component Rictor regulates the phosphorylation of ezrin; loss of Rictor leads to the uncontrolled reorganization of the actin network, resulting in impaired B cell receptor signaling and antibody response.
Converging evidence indicates that object segmentation is one and the same with feature extraction; the integrated nature of this perceptual mechanism defies current notions of separate top-down and bottom-up processes, offering a fresh view of how human vision operates on natural signals.
Functional changes at synapses between axons and oligodendrocyte precursor cells ' as well as proliferation and differentiation of oligodendrocyte precursor cells in vivo ' depend on the pattern of neuronal activity.
Genetic models in zebrafish, mouse and Drosophila, and gene expression analysis in primates, reveal unexpected evolutionary plasticity in the molecular and cellular mechanisms that link Wnt signaling to innate anxiety-like behavior.
Individuals in denser microbial populations are less likely to mutate to resist antibiotics; the same mutation avoidance mechanism underlies this phenomenon in two disparate organisms (the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae).
Comparative genomic profiling and in vivo reporter assays reveal previously unknown similarities between teleost and mammalian intestinal epithelial cells and identify conserved transcriptional regulatory sequences that are not typically detected by sequence conservation.