Piali Sengupta discusses the contribution of nearly three centuries of basic research on cilia biology to our understanding of animal physiology and human disease.
In this Research Matters article, Gregory Quirk discusses how research on learned fear responses can be applied to the treatment of anxiety disorders, and how we can increase ethnic diversity in neuroscience.
In a data-driven digital era is the way we conduct biomedical research optimal? This essay argues that when compared to born digital enterprises it is not, and considers possible solutions.
What can journals do to counteract the persisting problem of cell line cross-contamination in the published literature? This Perspective article examines what happened when the International Journal of Cancer took the lead by mandating cell line authentication at the point of submission.
The issue of non-replicable evidence has attracted considerable attention across biomedical and other sciences. This Perspective article proposes that biomedical scientists' efforts to improve reproducibility can be facilitated by insights and methodological approaches used in economics.
The School Malaise Trap Program teams up with thousands of students and educators across Canada to explore the arthropod diversity found in their schoolyards by utilizing DNA barcoding.
This Community Page article describes the authors' experience of developing and producing "Gut Check: The Microbiome Game," which was created to be both educational as well as fun and challenging to play.
Small in-host ˜fluctuations' in sequence and structural properties of HIV's Env protein among co-circulating viruses can predict the population-level changes that occurred in this protein over the past three decades.
Adult neurogenesis in the hippocampus affects adaptive behavior when cues are ambiguous, even when cue discrimination, or pattern separation, is not possible.
Post-translational S-nitrosylation of actin by nitric oxide from endothelial nitric oxide synthase regulates the organization of protein kinase C-q and its signalling at the immune synapse of T cells.
Adaptation of stickleback color vision genes to life in blackwater lakes shows that convergent evolution can be based on the same genetic mechanism over very different evolutionary time scales.
This study establishes the ability of the bacterium Bordetella bronchiseptica to evade amoebic predation while exploiting the amoeba as a dissemination and expansion vector, thereby identifying a novel environmental reservoir for bordetellae.
Vertebrate cone photoreceptors optimize their signal transmission by speeding up in high-contrast natural lighting conditions'and slowing down in low-contrast conditions'via modulation of the voltage activated current, Ih.
Pharmacological studies of diffusion fMRI using anaesthetic agents and various challenges reveal that water diffusion (apparent diffusion coefficient, or ADC) quantitatively reflects the underlying neural activity and is associated with local cell swelling.
Genetic variation within bird species forms a latitudinal diversity gradient that is similar to the pattern of high species diversity in the tropics.
How does the cell balance exocytosis with endocytosis? This study reveals how a synaptic vesicle-associated calcium channel, transferred to endocytic zones during neurotransmission, promotes one form of endocytosis under mild stimulation and'by triggering calcium influx'another form under intense stimulation.
Temporally resolved measurements of chromatin accessibility, H3K27ac enrichment and RNA polymerase II loading in mouse liver around the clock shed light on the underlying circadian gene regulatory network and its transcriptional interconnection with the feeding-fasting cycles.
Compensation in multi-drug resistant bacteria can be driven by further mutations that in turn compensate for the epistatic interactions between the resistance mutations; this favors the stabilization of multiple resistances in bacterial populations
A multiscale model and imaging data show that cells of the slime mold Dictyostelium discoideum maximize their cell'cell communication range during aggregation by a critical-like state known from phase transitions in physical systems.
A study of gene expression patterns in the developing nervous system of the basal chordate amphioxus highlights its complex molecular regionalization and challenges the classic separation between forebrain and midbrain in vertebrate brains.
Animals control their diet by regulating intake of specific nutrients, including proteins. This study identifies essential amino acids and'surprisingly'specific gut bacteria as key factors regulating protein appetite.
A comparative intracranial recording study in human and nonhuman primates shows how learning to predict the order of environmental events coordinates diverse neuronal responses across time and scale.
The Mlh1-Mlh3 endonuclease functions in meiotic recombination to resolve double Holliday Junction intermediates into crossovers. Biochemical analysis shows that, rather than acting as a structure-specific endonuclease, Mlh1-Mlh3 forms polymers that are required to generate nicks in DNA.