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New Articles in PLOS Biology

Published December 01, 2016 to December 30, 2016

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PLOS Biology
Volume 14(12) December 2016

View Table of Contents on web site


A Speculative History of DNA: What If Oswald Avery Had Died in 1934?
Matthew Cobb


Why Having a (Nonfinancial) Interest Is Not a Conflict of Interest
Lisa A. Bero, Quinn Grundy

Languages Are Still a Major Barrier to Global Science
Tatsuya Amano, Juan P. González-Varo, William J. Sutherland

Community Pages

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine
Ulrich Dirnagl, Ingo Przesdzing, Claudia Kurreck, Sebastian Major

Accelerating Translational Research through Open Science: The Neuro Experiment
E. Richard Gold

Lifemap: Exploring the Entire Tree of Life
Damien M. de Vienne

Open Highlights

Seven Glimpses into the Emotional Brain
Gabriel Gasque

Meta-Research Article

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor
Lucile Vogt, Thomas S. Reichlin, Christina Nathues, Hanno Würbel

Research Articles

The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications
Benoît S. Assogba, Pascal Milesi, Luc S. Djogbénou, Arnaud Berthomieu, Patrick Makoundou, Lamine S. Baba-Moussa, Anna-Sophie Fiston-Lavier, Khalid Belkhir, Pierrick Labbé, Mylène Weill

A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression
Andreas Klaus, Dietmar Plenz

Why don’t neuronal “avalanches” in resting-state cortex cause involuntary movements? This study shows that a low-correlation striatal resting state suppresses such movements and explores mechanisms that disrupt this inhibition.

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling
Liina Jakobson, Lauri Vaahtera, Kadri Tõldsepp, Maris Nuhkat, Cun Wang, Yuh-Shuh Wang, Hanna Hõrak, Ervin Valk, Priit Pechter, Yana Sindarovska, Jing Tang, Chuanlei Xiao, Yang Xu, Ulvi Gerst Talas, Alfonso T. García-Sosa, Saijaliisa Kangasjärvi, Uko Maran, Maido Remm, M. Rob G. Roelfsema, Honghong Hu, Jaakko Kangasjärvi, Mart Loog, Julian I. Schroeder, Hannes Kollist, Mikael Brosché

Climate-Related Local Extinctions Are Already Widespread among Plant and Animal Species
John J. Wiens

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
Kushol Gupta, Vesa Turkki, Scott Sherrill-Mix, Young Hwang, Grant Eilers, Louis Taylor, Charlene McDanal, Ping Wang, David Temelkoff, Robert T. Nolte, Emile Velthuisen, Jerry Jeffrey, Gregory D. Van Duyne, Frederic D. Bushman

A new crystal structure of the HIV integrase enzyme in complex with the allosteric inhibitor GSK1264 explains how the drug induces aggregation of the viral protein.

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity
Christopher J. Folts, Nicole Scott-Hewitt, Christoph Pröschel, Margot Mayer-Pröschel, Mark Noble

Different structurally related lipids from three genetically distinct lysosomal storage disorders are sufficient to cause multiple dysfunctions that converge on disruption of lysosomal pH as a core pathogenic mechanism.

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
Wanil Kim, Andrew T. Ludlow, Jaewon Min, Jerome D. Robin, Guido Stadler, Ilgen Mender, Tsung-Po Lai, Ning Zhang, Woodring E. Wright, Jerry W. Shay

Getting Road Expansion on the Right Track: A Framework for Smart Infrastructure Planning in the Mekong
Andrew Balmford, Huafang Chen, Ben Phalan, Mingcheng Wang, Christine O’Connell, Cath Tayleur, Jianchu Xu

Suppression of Dopamine Neurons Mediates Reward
Nobuhiro Yamagata, Makoto Hiroi, Shu Kondo, Ayako Abe, Hiromu Tanimoto

Transient suppression of a specific subset of dopamine neurons signals reward in the fruit fly Drosophila, suggesting that basal dopamine activity underlies behaviorally relevant valence coding.

Selection for Mitochondrial Quality Drives Evolution of the Germline
Arunas L. Radzvilavicius, Zena Hadjivasiliou, Andrew Pomiankowski, Nick Lane

Cell Fate Decision as High-Dimensional Critical State Transition
Mitra Mojtahedi, Alexander Skupin, Joseph Zhou, Ivan G. Castaño, Rebecca Y. Y. Leong-Quong, Hannah Chang, Kalliopi Trachana, Alessandro Giuliani, Sui Huang

Shedding Light on the Grey Zone of Speciation along a Continuum of Genomic Divergence
Camille Roux, Christelle Fraïsse, Jonathan Romiguier, Yoann Anciaux, Nicolas Galtier, Nicolas Bierne

Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation
Robin A. Sorg, Leo Lin, G. Sander van Doorn, Moritz Sorg, Joshua Olson, Victor Nizet, Jan-Willem Veening

Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process
Angélique Richard, Loïs Boullu, Ulysse Herbach, Arnaud Bonnafoux, Valérie Morin, Elodie Vallin, Anissa Guillemin, Nan Papili Gao, Rudiyanto Gunawan, Jérémie Cosette, Ophélie Arnaud, Jean-Jacques Kupiec, Thibault Espinasse, Sandrine Gonin-Giraud, Olivier Gandrillon

A single-cell transcriptomics analysis offers a new dynamical view of the differentiation process, involving an increase in between-cell variability prior to commitment.

Transient Duplication-Dependent Divergence and Horizontal Transfer Underlie the Evolutionary Dynamics of Bacterial Cell–Cell Signaling
Eran Even-Tov, Shira Omer Bendori, Shaul Pollak, Avigdor Eldar


Correction: Associative Mechanisms Allow for Social Learning and Cultural Transmission of String Pulling in an Insect
Sylvain Alem, Clint J. Perry, Xingfu Zhu, Olli J. Loukola, Thomas Ingraham, Eirik Søvik, Lars Chittka

Correction: Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells
Jacquelyn Freund, Rebecca M. May, Enjun Yang, Hongchuan Li, Matthew McCullen, Bin Zhang, Todd Lenvik, Frank Cichocki, Stephen K. Anderson, Taku Kambayashi

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