This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature


Volume 573 Issue 7775, 26 September 2019

Volume 573 Issue 7775, 26 September 2019

Brain tumours take root

Brain tumours are among the most lethal cancers. Primary brain tumours called malignant gliomas and brain metastases from other organs are particularly intractable. Three papers in this week’s issue probe the nature of brain tumour growth, shedding light on how the cancerous cells hijack and integrate into the brain’s neural network. Michelle Monje and her colleagues, and Frank Winkler and his team each find that cancerous glioma cells form functional synapses with neurons. Douglas Hanahan and his co-workers demonstrate that breast cancer cells metastatic to the brain participate in synaptic structures as a perisynaptic partner. The cancerous cells then use these synapses to promote their growth — the researchers find that activation of the synapses is associated with cancer colonization of the brain, malignant cell proliferation and tumour growth, emphasizing the role played by neuronal activity in brain cancer.

Cover image: Rob Dobi

This Week

News in Focus

Comment

Technology

    Technology Feature

  • Technology Feature |

    The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome.

    • Esther Landhuis

Careers

    Columns

  • Career Column |

    A chance visit to the Science Museum in London brought Emily Scott-Dearing into science communication.

    • Emily Scott-Dearing

Futures

Research

    News & Views

  • News & Views |

    Kimberlites are volcanic rocks that derive from deep in Earth’s mantle, but the nature of their source is uncertain. A study of this source’s evolution over two billion years provides valuable information about its properties.

    • Catherine Chauvel
  • News & Views |

    T-cell receptors orchestrate immune-system responses against infection and cancer. A structure of an entire T-cell receptor complex clarifies its assembly and signalling, and sheds light on its dynamic ligand recognition.

    • Ellis L. Reinherz
  • News & Views |

    How Nature reported political support for European union in 1969, and early studies of the effects of sewage on fish from 1919.

  • News & Views |

    Little was known about the properties of hydrogen under extreme pressure. Experiments now reveal key details about the arrangement of molecules in several of the element’s high-pressure phases.

    • Bartomeu Monserrat
    •  & Chris J. Pickard
  • Reviews

  • Review Article |

    Progress in integrating atomically thin two-dimensional materials with silicon-based technology is reviewed, together with the associated opportunities and challenges, and a roadmap for future applications is presented.

    • Deji Akinwande
    • , Cedric Huyghebaert
    • , Ching-Hua Wang
    • , Martha I. Serna
    • , Stijn Goossens
    • , Lain-Jong Li
    • , H.-S. Philip Wong
    •  & Frank H. L. Koppens
  • Articles

  • Article |

    Multivalent anions are found to be capable of electron-doping polymer semiconductors to realize conductive films with very low work functions, which enable efficient electron injection into materials with low electron affinity.

    • Cindy G. Tang
    • , Mazlan Nur Syafiqah
    • , Qi-Mian Koh
    • , Chao Zhao
    • , Jamal Zaini
    • , Qiu-Jing Seah
    • , Michael J. Cass
    • , Martin J. Humphries
    • , Ilaria Grizzi
    • , Jeremy H. Burroughes
    • , Rui-Qi Png
    • , Lay-Lay Chua
    •  & Peter K. H. Ho
  • Article |

    Breast-to-brain metastasis is enabled by activation of an N-methyl-d-aspartate receptor, which is achieved via the formation of pseudo-tripartite synapses between cancer cells and glutamatergic neurons.

    • Qiqun Zeng
    • , Iacovos P. Michael
    • , Peng Zhang
    • , Sadegh Saghafinia
    • , Graham Knott
    • , Wei Jiao
    • , Brian D. McCabe
    • , José A. Galván
    • , Hugh P. C. Robinson
    • , Inti Zlobec
    • , Giovanni Ciriello
    •  & Douglas Hanahan
  • Article |

    Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.

    • Varun Venkataramani
    • , Dimitar Ivanov Tanev
    • , Christopher Strahle
    • , Alexander Studier-Fischer
    • , Laura Fankhauser
    • , Tobias Kessler
    • , Christoph Körber
    • , Markus Kardorff
    • , Miriam Ratliff
    • , Ruifan Xie
    • , Heinz Horstmann
    • , Mirko Messer
    • , Sang Peter Paik
    • , Johannes Knabbe
    • , Felix Sahm
    • , Felix T. Kurz
    • , Azer Aylin Acikgöz
    • , Frank Herrmannsdörfer
    • , Amit Agarwal
    • , Dwight E. Bergles
    • , Anthony Chalmers
    • , Hrvoje Miletic
    • , Sevin Turcan
    • , Christian Mawrin
    • , Daniel Hänggi
    • , Hai-Kun Liu
    • , Wolfgang Wick
    • , Frank Winkler
    •  & Thomas Kuner
  • Article |

    Neurons form synapses onto glioma cells, and depolarization of glioma membranes promotes glioma growth in vivo, whereas blocking electrochemical signalling blocks tumour growth.

    • Humsa S. Venkatesh
    • , Wade Morishita
    • , Anna C. Geraghty
    • , Dana Silverbush
    • , Shawn M. Gillespie
    • , Marlene Arzt
    • , Lydia T. Tam
    • , Cedric Espenel
    • , Anitha Ponnuswami
    • , Lijun Ni
    • , Pamelyn J. Woo
    • , Kathryn R. Taylor
    • , Amit Agarwal
    • , Aviv Regev
    • , David Brang
    • , Hannes Vogel
    • , Shawn Hervey-Jumper
    • , Dwight E. Bergles
    • , Mario L. Suvà
    • , Robert C. Malenka
    •  & Michelle Monje
  • Article |

    A high-resolution cryo-electron microscopy structure of the human octameric T cell receptor–CD3 complex, including the complete extracellular and transmembrane domains, reveals the structural basis for TCR–CD3 assembly and provides insights into T cell receptor activation.

    • De Dong
    • , Lvqin Zheng
    • , Jianquan Lin
    • , Bailing Zhang
    • , Yuwei Zhu
    • , Ningning Li
    • , Shuangyu Xie
    • , Yuhang Wang
    • , Ning Gao
    •  & Zhiwei Huang
  • Letters

  • Letter |

    Transmission of single-spin and entangled quantum states without the physical displacement of electrons is demonstrated in a quadruple quantum dot array using the Heisenberg exchange interaction and coherent SWAP gates.

    • Yadav P. Kandel
    • , Haifeng Qiao
    • , Saeed Fallahi
    • , Geoffrey C. Gardner
    • , Michael J. Manfra
    •  & John M. Nichol
  • Letter |

    X-ray diffraction measurements of solid hydrogen provide crystallographic information for high-pressure phases of hydrogen and transitions between them, suggesting a series of isostructural transitions under compression before band closure and metallization.

    • Cheng Ji
    • , Bing Li
    • , Wenjun Liu
    • , Jesse S. Smith
    • , Arnab Majumdar
    • , Wei Luo
    • , Rajeev Ahuja
    • , Jinfu Shu
    • , Junyue Wang
    • , Stanislav Sinogeikin
    • , Yue Meng
    • , Vitali B. Prakapenka
    • , Eran Greenberg
    • , Ruqing Xu
    • , Xianrong Huang
    • , Wenge Yang
    • , Guoyin Shen
    • , Wendy L. Mao
    •  & Ho-Kwang Mao
  • Letter |

    A statistical forecast model using a deep-learning approach produces useful forecasts of El Niño/Southern Oscillation events with lead times of up to one and a half years.

    • Yoo-Geun Ham
    • , Jeong-Hwan Kim
    •  & Jing-Jia Luo
  • Letter |

    A global dataset of river longitudinal profiles shows that river profiles become straighter with increasing aridity and numerical modelling suggests that this can be explained by rainfall–runoff regimes in different climate zones.

    • Shiuan-An Chen
    • , Katerina Michaelides
    • , Stuart W. D. Grieve
    •  & Michael Bliss Singer
  • Letter |

    Globally distributed kimberlites have their origins in a single, homogeneous early Earth reservoir that was subsequently perturbed, probably by subduction along the margins of Pangaea, around 200 million years ago.

    • Jon Woodhead
    • , Janet Hergt
    • , Andrea Giuliani
    • , Roland Maas
    • , David Phillips
    • , D. Graham Pearson
    •  & Geoff Nowell
  • Letter |

    Wilderness areas with minimal levels of human disturbance promote the persistence of biodiversity by acting as buffers against species loss, and therefore represent key targets for environmental protection.

    • Moreno Di Marco
    • , Simon Ferrier
    • , Tom D. Harwood
    • , Andrew J. Hoskins
    •  & James E. M. Watson
  • Letter |

    Mollisonia plenovenatrix, a small predatory arthropod from the Burgess Shale dated to about 508 million years ago, is morphologically close to horseshoe crabs, which suggests chelicerates arose as micropredators early during the Cambrian explosion.

    • Cédric Aria
    •  & Jean-Bernard Caron
  • Letter |

    The RNA helicase DDX3X has a critical role in regulating both the induction of stress granules and the activation of the NLRP3 inflammasome in cells under stress conditions.

    • Parimal Samir
    • , Sannula Kesavardhana
    • , Deanna M. Patmore
    • , Sebastien Gingras
    • , R. K. Subbarao Malireddi
    • , Rajendra Karki
    • , Clifford S. Guy
    • , Benoit Briard
    • , David E. Place
    • , Anannya Bhattacharya
    • , Bhesh Raj Sharma
    • , Amanda Nourse
    • , Sharon V. King
    • , Aaron Pitre
    • , Amanda R. Burton
    • , Stephane Pelletier
    • , Richard J. Gilbertson
    •  & Thirumala-Devi Kanneganti
  • Letter |

    Restoring the function of p53 in a mouse model of pancreatic ductal adenocarcinoma leads to the accumulation of α-ketoglutarate, which increases levels of the 5-hydroxymethylcytosine chromatin modification and results in reduced tumour-cell fitness.

    • John P. Morris IV
    • , Jossie J. Yashinskie
    • , Richard Koche
    • , Rohit Chandwani
    • , Sha Tian
    • , Chi-Chao Chen
    • , Timour Baslan
    • , Zoran S. Marinkovic
    • , Francisco J. Sánchez-Rivera
    • , Steven D. Leach
    • , Carlos Carmona-Fontaine
    • , Craig B. Thompson
    • , Lydia W. S. Finley
    •  & Scott W. Lowe
  • Letter |

    V(D)J recombination in B cells involves cohesin-mediated extrusion of chromatin loops to present DNA targets for cleavage and joining.

    • Yu Zhang
    • , Xuefei Zhang
    • , Zhaoqing Ba
    • , Zhuoyi Liang
    • , Edward W. Dring
    • , Hongli Hu
    • , Jiangman Lou
    • , Nia Kyritsis
    • , Jeffrey Zurita
    • , Muhammad S. Shamim
    • , Aviva Presser Aiden
    • , Erez Lieberman Aiden
    •  & Frederick W. Alt
  • Letter |

    Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to elongation.

    • Jinfan Wang
    • , Alex G. Johnson
    • , Christopher P. Lapointe
    • , Junhong Choi
    • , Arjun Prabhakar
    • , Dong-Hua Chen
    • , Alexey N. Petrov
    •  & Joseph D. Puglisi
  • Letter |

    Structural and biophysical studies reveal that low-barrier hydrogen bonds enable long-range communication between the active sites of multimeric enzymes and synchronise catalysis.

    • Shaobo Dai
    • , Lisa-Marie Funk
    • , Fabian Rabe von Pappenheim
    • , Viktor Sautner
    • , Mirko Paulikat
    • , Benjamin Schröder
    • , Jon Uranga
    • , Ricardo A. Mata
    •  & Kai Tittmann

Amendments & Corrections

Nature Outlook

  • Nature Outlook |

    Digital health

    There are now few areas of our lives that artificial intelligence (AI) does not touch. Not only is medicine no exception, but the potential for digital transformation of health care is especially striking.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing