This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature


Volume 573 Issue 7774, 19 September 2019

Volume 573 Issue 7774, 19 September 2019

Time to act

Climate change is arguably the scientific and societal issue of our age. Unless drastic action is taken, Earth is likely to exceed 3 °C of warming by the end of the century, bringing with it unprecedented weather extremes, rising seas, mass extinctions and human misery. The science and the threat are clear − but the world and its leaders are proving slow to respond. This week, Nature is joining with more than 220 media outlets worldwide in Covering Climate Now, a coordinated initiative to raise the profile of climate coverage in the run up to the UN climate summit in New York on 23 September. With a growing youth climate movement calling for climate strikes, the energy and intensity of the debate is ramping up. Human ingenuity is up to the challenge — but only if societies, industries and governments resolve to act, and act now.

Cover: Jasiek Krzysztofiak/Nature

This Week

News in Focus

Comment

Careers

    Q&A

  • Columns

  • Career Column |

    Researchers should learn to travel better to mitigate their climate impacts. Institutions can help by facilitating and rewarding sustainable travel behaviour, rather than fuelling the pressure to attend conferences, say Olivier Hamant, Timothy Saunders and Virgile Viasnoff.

    • Olivier Hamant
    • , Timothy Saunders
    •  & Virgile Viasnoff

Futures

Research

    News & Views

  • News & Views Forum |

    Researchers and policymakers rely on computer simulations called integrated assessment models to determine the best strategies for tackling climate change. Here, scientists present opposing views on the suitability of these simulations.

    • Kevin Anderson
    •  & Jessica Jewell
  • News & Views |

    An innovative microfluidic device has enabled the modelling of the events that occur in human embryos when they implant in the wall of the uterus. It could be used to help understand early pregnancy loss.

    • Amander T. Clark
  • News & Views |

    Circuits based on the stochastic evolution of nanoscale magnets have been used to split large numbers into prime-number factors — a problem that only quantum computers were previously expected to solve efficiently.

    • Dmitri E. Nikonov
  • News & Views |

    How Nature reported hominid remains in 1969 and sea-fishery investigations in 1919.

  • News & Views |

    How cancer cells migrate to a secondary site and become established there is not fully understood. An analysis of mouse and human cancer cells could help settle the debate about the role of the protein E-cadherin in this process.

    • Roger R. Gomis
  • News & Views |

    Histone proteins pack DNA into a condensed form called chromatin. Detailed structures of the MLL family of histone-modifying protein complexes have been defined, shedding light on how they operate.

    • Steven J. Gamblin
    •  & Jon R. Wilson
  • Articles

  • Article |

    Fundamental value judgments about acceptable maximum levels of climate change and future reliance on controversial technologies can be made explicitly in climate scenarios, thereby addressing the intergenerational bias present in the scenario literature.

    • Joeri Rogelj
    • , Daniel Huppmann
    • , Volker Krey
    • , Keywan Riahi
    • , Leon Clarke
    • , Matthew Gidden
    • , Zebedee Nicholls
    •  & Malte Meinshausen
  • Article | | Open Access

    A US national experiment showed that a short, online, self-administered growth mindset intervention can increase adolescents’ grades and advanced course-taking, and identified the types of school that were poised to benefit the most.

    • David S. Yeager
    • , Paul Hanselman
    • , Gregory M. Walton
    • , Jared S. Murray
    • , Robert Crosnoe
    • , Chandra Muller
    • , Elizabeth Tipton
    • , Barbara Schneider
    • , Chris S. Hulleman
    • , Cintia P. Hinojosa
    • , David Paunesku
    • , Carissa Romero
    • , Kate Flint
    • , Alice Roberts
    • , Jill Trott
    • , Ronaldo Iachan
    • , Jenny Buontempo
    • , Sophia Man Yang
    • , Carlos M. Carvalho
    • , P. Richard Hahn
    • , Maithreyi Gopalan
    • , Pratik Mhatre
    • , Ronald Ferguson
    • , Angela L. Duckworth
    •  & Carol S. Dweck
  • Article |

    In the brains of embryonic mice, some types of progenitor (apical progenitors) can revert to earlier molecular, electrophysiological and neurogenic states when transplanted into younger hosts, whereas others cannot, highlighting progenitor-type-specific differences in fate plasticity.

    • Polina Oberst
    • , Sabine Fièvre
    • , Natalia Baumann
    • , Cristina Concetti
    • , Giorgia Bartolini
    •  & Denis Jabaudon
  • Article |

    The cryo-electron microscopy structures of an early spliceosome complex in yeast reveal a unified mechanism for defining introns and exons and also for back-splicing to generate circular RNA.

    • Xueni Li
    • , Shiheng Liu
    • , Lingdi Zhang
    • , Aaron Issaian
    • , Ryan C. Hill
    • , Sara Espinosa
    • , Shasha Shi
    • , Yanxiang Cui
    • , Kalli Kappel
    • , Rhiju Das
    • , Kirk C. Hansen
    • , Z. Hong Zhou
    •  & Rui Zhao
  • Letters

  • Letter |

    Galaxy GSN 069 has unprecedented eruptions of X-ray light every nine hours, which indicate fast transitions between cold and warm states and may shed light on black hole accretion.

    • G. Miniutti
    • , R. D. Saxton
    • , M. Giustini
    • , K. D. Alexander
    • , R. P. Fender
    • , I. Heywood
    • , I. Monageng
    • , M. Coriat
    • , A. K. Tzioumis
    • , A. M. Read
    • , C. Knigge
    • , P. Gandhi
    • , M. L. Pretorius
    •  & B. Agís-González
  • Letter |

    Quantum critical behaviour at the many-body localization transition in a disordered Bose–Hubbard system of bosonic rubidium atoms in an optical lattice is observed, connecting the macroscopic phenomenology of the transition to the system’s microscopic quantum correlations.

    • Matthew Rispoli
    • , Alexander Lukin
    • , Robert Schittko
    • , Sooshin Kim
    • , M. Eric Tai
    • , Julian Léonard
    •  & Markus Greiner
  • Letter |

    A probabilistic computer utilizing probabilistic bits, or p-bits, is implemented with stochastic nanomagnetic devices in a neural-network-inspired electrical circuit operating at room temperature and demonstrates integer factorization up to 945.

    • William A. Borders
    • , Ahmed Z. Pervaiz
    • , Shunsuke Fukami
    • , Kerem Y. Camsari
    • , Hideo Ohno
    •  & Supriyo Datta
  • Letter |

    A route to the synthesis of hindered ethers is developed, in which electrochemical oxidation is used to liberate high-energy carbocations that are then captured by an alcohol.

    • Jinbao Xiang
    • , Ming Shang
    • , Yu Kawamata
    • , Helena Lundberg
    • , Solomon H. Reisberg
    • , Miao Chen
    • , Pavel Mykhailiuk
    • , Gregory Beutner
    • , Michael R. Collins
    • , Alyn Davies
    • , Matthew Del Bel
    • , Gary M. Gallego
    • , Jillian E. Spangler
    • , Jeremy Starr
    • , Shouliang Yang
    • , Donna G. Blackmond
    •  & Phil S. Baran
  • Letter |

    Observations and regional climate models show that the increasing coverage of ice slabs on the Greenland ice sheet could lead to a global sea-level rise of up to 74 millimetres by 2100.

    • M. MacFerrin
    • , H. Machguth
    • , D. van As
    • , C. Charalampidis
    • , C. M. Stevens
    • , A. Heilig
    • , B. Vandecrux
    • , P. L. Langen
    • , R. Mottram
    • , X. Fettweis
    • , M. R. van den Broeke
    • , W. T. Pfeffer
    • , M. S. Moussavi
    •  & W. Abdalati
  • Letter |

    Whole-genome sequencing of the strains of the Saccharomyces cerevisiae gene-knockout collection reveals the effects of the deletion of non-essential genes on genome stability.

    • Fabio Puddu
    • , Mareike Herzog
    • , Alexandra Selivanova
    • , Siyue Wang
    • , Jin Zhu
    • , Shir Klein-Lavi
    • , Molly Gordon
    • , Roi Meirman
    • , Gonzalo Millan-Zambrano
    • , Iñigo Ayestaran
    • , Israel Salguero
    • , Roded Sharan
    • , Rong Li
    • , Martin Kupiec
    •  & Stephen P. Jackson
  • Letter |

    Landmarks of early stages of human embryogenesis can be recapitulated in a highly controllable and scalable fashion by culturing human pluripotent stem cells in a microfluidic device.

    • Yi Zheng
    • , Xufeng Xue
    • , Yue Shao
    • , Sicong Wang
    • , Sajedeh Nasr Esfahani
    • , Zida Li
    • , Jonathon M. Muncie
    • , Johnathon N. Lakins
    • , Valerie M. Weaver
    • , Deborah L. Gumucio
    •  & Jianping Fu
  • Letter |

    The cellular degradative machinery can be asymmetrically inherited upon haematopoietic-stem-cell division, which predicts the future metabolic and translational activation of their daughter cells.

    • Dirk Loeffler
    • , Arne Wehling
    • , Florin Schneiter
    • , Yang Zhang
    • , Niklas Müller-Bötticher
    • , Philipp S. Hoppe
    • , Oliver Hilsenbeck
    • , Konstantinos D. Kokkaliaris
    • , Max Endele
    •  & Timm Schroeder
  • Letter |

    Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury in mice, providing proof-of-principle for the development of immunotherapeutic treatments for cardiac disease.

    • Haig Aghajanian
    • , Toru Kimura
    • , Joel G. Rurik
    • , Aidan S. Hancock
    • , Michael S. Leibowitz
    • , Li Li
    • , John Scholler
    • , James Monslow
    • , Albert Lo
    • , Wei Han
    • , Tao Wang
    • , Kenneth Bedi
    • , Michael P. Morley
    • , Ricardo A. Linares Saldana
    • , Nikhita A. Bolar
    • , Kendra McDaid
    • , Charles-Antoine Assenmacher
    • , Cheryl L. Smith
    • , Dagmar Wirth
    • , Carl H. June
    • , Kenneth B. Margulies
    • , Rajan Jain
    • , Ellen Puré
    • , Steven M. Albelda
    •  & Jonathan A. Epstein
  • Letter |

    A genome-wide CRISPR-interference screen is used to identify the reduced folate carrier SLC19A1 as the major transporter of cyclic dinucleotides in human cells, with potential roles in immunotherapeutic treatment of cancer, immune responses to pathogens and inflammatory diseases.

    • Rutger D. Luteijn
    • , Shivam A. Zaver
    • , Benjamin G. Gowen
    • , Stacia K. Wyman
    • , Nick E. Garelis
    • , Liberty Onia
    • , Sarah M. McWhirter
    • , George E. Katibah
    • , Jacob E. Corn
    • , Joshua J. Woodward
    •  & David H. Raulet
  • Letter |

    Although E-cadherin loss promotes tumour-cell invasion in mouse and human models of invasive ductal carcinoma, E-cadherin expression prevents oxidative-stress-mediated apoptosis during detachment and is essential for metastasis.

    • Veena Padmanaban
    • , Ilona Krol
    • , Yasir Suhail
    • , Barbara M. Szczerba
    • , Nicola Aceto
    • , Joel S. Bader
    •  & Andrew J. Ewald
  • Letter |

    Cryo-electron microscopy structures of mixed-lineage leukaemia methyltransferases 1 and 3 associated with unmodified or mono-ubiquitinated nucleosome reveal the structural basis for the activity specificity and regulation of these enzymes.

    • Han Xue
    • , Tonghui Yao
    • , Mi Cao
    • , Guanjun Zhu
    • , Yan Li
    • , Guiyong Yuan
    • , Yong Chen
    • , Ming Lei
    •  & Jing Huang

Nature Outlook

  • Nature Outlook |

    Influenza

    Influenza kills up to 500,000 people annually. The influenza virus mutates to evade our immune system and occasionally changes drastically to become a new subtype that can start a pandemic.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing