This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 550 Number 7677 pp429-554

26 October 2017

About the cover

The cover shows an intricate network of lattice defects — dislocation lines — whose motion makes metal tantalum flow under compression. Fully dynamic atomistic simulations of plastic deformation in metals are extremely demanding computationally and usually involve mesoscale approximations. In this issue, Vasily Bulatov and his colleagues present fully dynamic atomic-level simulations of metal plasticity that feature up to 268 million atoms, each such simulation generating around 2 exabytes (1 exabyte = 1018 bytes) of data. Using their model, the authors probe how body-centred-cubic metal tantalum responds to ultrahigh-strain-rate deformation. They find that on reaching certain limiting conditions, dislocations can no longer relieve mechanical loads and twinning — the sudden reorientation of the crystal lattice — takes over. They also find that below such critical conditions, flow stress and dislocation density achieve a steady state in which the metal can be kneaded indefinitely like a piece of dough. Cover image: Alexander Stukowski

This Week



World View


Research Highlights


Seven Days


News in Focus




Books and Arts







naturejobs job listings and advertising features



outline: Non-union bone fracture

Produced with support from:




  • Molecular basis of USP7 inhibition by selective small-molecule inhibitors

    • Andrew P. Turnbull
    • Stephanos Ioannidis
    • Wojciech W. Krajewski
    • Adan Pinto-Fernandez
    • Claire Heride
    • Agnes C. L. Martin
    • Louise M. Tonkin
    • Elizabeth C. Townsend
    • Shane M. Buker
    • David R. Lancia
    • Justin A. Caravella
    • Angela V. Toms
    • Thomas M. Charlton
    • Johanna Lahdenranta
    • Erik Wilker
    • Bruce C. Follows
    • Nicola J. Evans
    • Lucy Stead
    • Cristina Alli
    • Vladislav V. Zarayskiy
    • Adam C. Talbot
    • Alexandre J. Buckmelter
    • Minghua Wang
    • Crystal L. McKinnon
    • Fabienne Saab
    • Joanna F. McGouran
    • Hannah Century
    • Malte Gersch
    • Marc S. Pittman
    • C. Gary Marshall
    • Tony M. Raynham
    • Mary Simcox
    • Lorna M. D. Stewart
    • Sheila B. McLoughlin
    • Jaime A. Escobedo
    • Kenneth W. Bair
    • Christopher J. Dinsmore
    • Tim R. Hammonds
    • Sunkyu Kim
    • Sylvie Urbé
    • Michael J. Clague
    • Benedikt M. Kessler
    • David Komander

    Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

    See also




  • Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

    • Aldo Scarpa
    • David K. Chang
    • Katia Nones
    • Vincenzo Corbo
    • Ann-Marie Patch
    • Peter Bailey
    • Rita T. Lawlor
    • Amber L. Johns
    • David K. Miller
    • Andrea Mafficini
    • Borislav Rusev
    • Maria Scardoni
    • Davide Antonello
    • Stefano Barbi
    • Katarzyna O. Sikora
    • Sara Cingarlini
    • Caterina Vicentini
    • Skye McKay
    • Michael C. J. Quinn
    • Timothy J. C. Bruxner
    • Angelika N. Christ
    • Ivon Harliwong
    • Senel Idrisoglu
    • Suzanne McLean
    • Craig Nourse
    • Ehsan Nourbakhsh
    • Peter J. Wilson
    • Matthew J. Anderson
    • J. Lynn Fink
    • Felicity Newell
    • Nick Waddell
    • Oliver Holmes
    • Stephen H. Kazakoff
    • Conrad Leonard
    • Scott Wood
    • Qinying Xu
    • Shivashankar Hiriyur Nagaraj
    • Eliana Amato
    • Irene Dalai
    • Samantha Bersani
    • Ivana Cataldo
    • Angelo P. Dei Tos
    • Paola Capelli
    • Maria Vittoria Davì
    • Luca Landoni
    • Anna Malpaga
    • Marco Miotto
    • Vicki L. J. Whitehall
    • Barbara A. Leggett
    • Janelle L. Harris
    • Jonathan Harris
    • Marc D. Jones
    • Jeremy Humphris
    • Lorraine A. Chantrill
    • Venessa Chin
    • Adnan M. Nagrial
    • Marina Pajic
    • Christopher J. Scarlett
    • Andreia Pinho
    • Ilse Rooman
    • Christopher Toon
    • Jianmin Wu
    • Mark Pinese
    • Mark Cowley
    • Andrew Barbour
    • Amanda Mawson
    • Emily S. Humphrey
    • Emily K. Colvin
    • Angela Chou
    • Jessica A. Lovell
    • Nigel B. Jamieson
    • Fraser Duthie
    • Marie-Claude Gingras
    • William E. Fisher
    • Rebecca A. Dagg
    • Loretta M. S. Lau
    • Michael Lee
    • Hilda A. Pickett
    • Roger R. Reddel
    • Jaswinder S. Samra
    • James G. Kench
    • Neil D. Merrett
    • Krishna Epari
    • Nam Q. Nguyen
    • Nikolajs Zeps
    • Massimo Falconi
    • Michele Simbolo
    • Giovanni Butturini
    • George Van Buren
    • Stefano Partelli
    • Matteo Fassan
    • Australian Pancreatic Cancer Genome Initiative
    • Kum Kum Khanna
    • Anthony J. Gill
    • David A. Wheeler
    • Richard A. Gibbs
    • Elizabeth A. Musgrove
    • Claudio Bassi
    • Giampaolo Tortora
    • Paolo Pederzoli
    • John V. Pearson
    • Nicola Waddell
    • Andrew V. Biankin
    • Sean M. Grimmond