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Current Issue of Nature


Volume 562 Issue 7725, 4 October 2018

Volume 562 Issue 7725, 4 October 2018

Volume 562 Issue 7725

Science shared

The cover image shows Remisy (left), an oral historian of the Mikea people, discussing the history of a settlement in the Namonte basin in Madagascar with Tsiazonera (right), a historian at the University of Toliara in Madagascar. Such integrated work is characteristic of the co-production of research, in which the people who will be affected by a study’s outcomes are getting involved in designing and driving the research itself. Such co-production is reshaping the scientific landscape, with stakeholders, scientists and societies working shoulder to shoulder to make a difference. In a special issue, Nature looks at the promise and the pitfalls of research co-production, offering guiding principles, case studies and personal reflections on how this cultural shift can help make science more relevant and useful.

Cover image: Garth Cripps

This Week

News in Focus

Comment

Technology

Careers

Futures

Research

    News & Views

  • News & Views |

    Increases in biomechanical forces in the liver’s blood vessels have now been shown to activate two mechanosensitive proteins. The proteins trigger blood-vessel cells to deploy regenerative factors that drive liver growth.

    • Sina Y. Rabbany
    •  & Shahin Rafii
  • News & Views |

    Some bacteria make energy in a process that is accompanied by transfer of electrons to a mineral. A previously unknown electron-transfer pathway now reveals an energy-generation system used by bacteria in the human gut.

    • Laty A. Cahoon
    •  & Nancy E. Freitag
  • News & Views |

    How the same type of cell can form different kinds of tumour isn’t always clear. The discovery that cancer subtype in mice is influenced by the type of cell death occurring in the microenvironment provides some insight.

    • Eli Pikarsky
  • News & Views |

    The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells have now been found in people with narcolepsy.

    • Roland S. Liblau
  • News & Views |

    What Nature was saying 50 and 100 years ago.

  • News & Views |

    An organic polymer exhibits a phase transition that is associated with improved electromechanical properties. This feature links organic polymers with widely used perovskite materials, and could have many applications.

    • Ronald E. Cohen
  • Reviews

  • Review Article |

    The current state of the search for dark-matter particles is reviewed, and a broader experimental and theoretical approach is proposed to solve the dark-matter problem.

    • Gianfranco Bertone
    •  & Tim M. P. Tait
  • Articles

  • Article |

    Analyses of the relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.

    • Anne D. Bjorkman
    • , Isla H. Myers-Smith
    • , Sarah C. Elmendorf
    • , Signe Normand
    • , Nadja Rüger
    • , Pieter S. A. Beck
    • , Anne Blach-Overgaard
    • , Daan Blok
    • , J. Hans C. Cornelissen
    • , Bruce C. Forbes
    • , Damien Georges
    • , Scott J. Goetz
    • , Kevin C. Guay
    • , Gregory H. R. Henry
    • , Janneke HilleRisLambers
    • , Robert D. Hollister
    • , Dirk N. Karger
    • , Jens Kattge
    • , Peter Manning
    • , Janet S. Prevéy
    • , Christian Rixen
    • , Gabriela Schaepman-Strub
    • , Haydn J. D. Thomas
    • , Mark Vellend
    • , Martin Wilmking
    • , Sonja Wipf
    • , Michele Carbognani
    • , Luise Hermanutz
    • , Esther Lévesque
    • , Ulf Molau
    • , Alessandro Petraglia
    • , Nadejda A. Soudzilovskaia
    • , Marko J. Spasojevic
    • , Marcello Tomaselli
    • , Tage Vowles
    • , Juha M. Alatalo
    • , Heather D. Alexander
    • , Alba Anadon-Rosell
    • , Sandra Angers-Blondin
    • , Mariska te Beest
    • , Logan Berner
    • , Robert G. Björk
    • , Agata Buchwal
    • , Allan Buras
    • , Katherine Christie
    • , Elisabeth J. Cooper
    • , Stefan Dullinger
    • , Bo Elberling
    • , Anu Eskelinen
    • , Esther R. Frei
    • , Oriol Grau
    • , Paul Grogan
    • , Martin Hallinger
    • , Karen A. Harper
    • , Monique M. P. D. Heijmans
    • , James Hudson
    • , Karl Hülber
    • , Maitane Iturrate-Garcia
    • , Colleen M. Iversen
    • , Francesca Jaroszynska
    • , Jill F. Johnstone
    • , Rasmus Halfdan Jørgensen
    • , Elina Kaarlejärvi
    • , Rebecca Klady
    • , Sara Kuleza
    • , Aino Kulonen
    • , Laurent J. Lamarque
    • , Trevor Lantz
    • , Chelsea J. Little
    • , James D. M. Speed
    • , Anders Michelsen
    • , Ann Milbau
    • , Jacob Nabe-Nielsen
    • , Sigrid Schøler Nielsen
    • , Josep M. Ninot
    • , Steven F. Oberbauer
    • , Johan Olofsson
    • , Vladimir G. Onipchenko
    • , Sabine B. Rumpf
    • , Philipp Semenchuk
    • , Rohan Shetti
    • , Laura Siegwart Collier
    • , Lorna E. Street
    • , Katharine N. Suding
    • , Ken D. Tape
    • , Andrew Trant
    • , Urs A. Treier
    • , Jean-Pierre Tremblay
    • , Maxime Tremblay
    • , Susanna Venn
    • , Stef Weijers
    • , Tara Zamin
    • , Noémie Boulanger-Lapointe
    • , William A. Gould
    • , David S. Hik
    • , Annika Hofgaard
    • , Ingibjörg S. Jónsdóttir
    • , Janet Jorgenson
    • , Julia Klein
    • , Borgthor Magnusson
    • , Craig Tweedie
    • , Philip A. Wookey
    • , Michael Bahn
    • , Benjamin Blonder
    • , Peter M. van Bodegom
    • , Benjamin Bond-Lamberty
    • , Giandiego Campetella
    • , Bruno E. L. Cerabolini
    • , F. Stuart Chapin III
    • , William K. Cornwell
    • , Joseph Craine
    • , Matteo Dainese
    • , Franciska T. de Vries
    • , Sandra Díaz
    • , Brian J. Enquist
    • , Walton Green
    • , Ruben Milla
    • , Ülo Niinemets
    • , Yusuke Onoda
    • , Jenny C. Ordoñez
    • , Wim A. Ozinga
    • , Josep Penuelas
    • , Hendrik Poorter
    • , Peter Poschlod
    • , Peter B. Reich
    • , Brody Sandel
    • , Brandon Schamp
    • , Serge Sheremetev
    •  & Evan Weiher
  • Article |

    The detection of hypocretin-specific autoreactive CD4+ and CD8+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder.

    • Daniela Latorre
    • , Ulf Kallweit
    • , Eric Armentani
    • , Mathilde Foglierini
    • , Federico Mele
    • , Antonino Cassotta
    • , Sandra Jovic
    • , David Jarrossay
    • , Johannes Mathis
    • , Francesco Zellini
    • , Burkhard Becher
    • , Antonio Lanzavecchia
    • , Ramin Khatami
    • , Mauro Manconi
    • , Mehdi Tafti
    • , Claudio L. Bassetti
    •  & Federica Sallusto
  • Article |

    The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

    • Marco Seehawer
    • , Florian Heinzmann
    • , Luana D’Artista
    • , Jule Harbig
    • , Pierre-François Roux
    • , Lisa Hoenicke
    • , Hien Dang
    • , Sabrina Klotz
    • , Lucas Robinson
    • , Grégory Doré
    • , Nir Rozenblum
    • , Tae-Won Kang
    • , Rishabh Chawla
    • , Thorsten Buch
    • , Mihael Vucur
    • , Mareike Roth
    • , Johannes Zuber
    • , Tom Luedde
    • , Bence Sipos
    • , Thomas Longerich
    • , Mathias Heikenwälder
    • , Xin Wei Wang
    • , Oliver Bischof
    •  & Lars Zender
  • Article |

    A method for systematically exploring interactions between the nucleosome and transcription factors identifies five major interaction patterns.

    • Fangjie Zhu
    • , Lucas Farnung
    • , Eevi Kaasinen
    • , Biswajyoti Sahu
    • , Yimeng Yin
    • , Bei Wei
    • , Svetlana O. Dodonova
    • , Kazuhiro R. Nitta
    • , Ekaterina Morgunova
    • , Minna Taipale
    • , Patrick Cramer
    •  & Jussi Taipale
  • Letters

  • Letter |

    Observations of teraelectronvolt γ-rays accelerated by the jets of the miniature quasar SS 433 are reported.

    • A. U. Abeysekara
    • , A. Albert
    • , R. Alfaro
    • , C. Alvarez
    • , J. D. Álvarez
    • , R. Arceo
    • , J. C. Arteaga-Velázquez
    • , D. Avila Rojas
    • , H. A. Ayala Solares
    • , E. Belmont-Moreno
    • , S. Y. BenZvi
    • , C. Brisbois
    • , K. S. Caballero-Mora
    • , T. Capistrán
    • , A. Carramiñana
    • , S. Casanova
    • , M. Castillo
    • , U. Cotti
    • , J. Cotzomi
    • , S. Coutiño de León
    • , C. De León
    • , E. De la Fuente
    • , J. C. Díaz-Vélez
    • , S. Dichiara
    • , B. L. Dingus
    • , M. A. DuVernois
    • , R. W. Ellsworth
    • , K. Engel
    • , C. Espinoza
    • , K. Fang
    • , H. Fleischhack
    • , N. Fraija
    • , A. Galván-Gámez
    • , J. A. García-González
    • , F. Garfias
    • , A. González-Muñoz
    • , M. M. González
    • , J. A. Goodman
    • , Z. Hampel-Arias
    • , J. P. Harding
    • , S. Hernandez
    • , J. Hinton
    • , B. Hona
    • , F. Hueyotl-Zahuantitla
    • , C. M. Hui
    • , P. Hüntemeyer
    • , A. Iriarte
    • , A. Jardin-Blicq
    • , V. Joshi
    • , S. Kaufmann
    • , P. Kar
    • , G. J. Kunde
    • , R. J. Lauer
    • , W. H. Lee
    • , H. León Vargas
    • , H. Li
    • , J. T. Linnemann
    • , A. L. Longinotti
    • , G. Luis-Raya
    • , R. López-Coto
    • , K. Malone
    • , S. S. Marinelli
    • , O. Martinez
    • , I. Martinez-Castellanos
    • , J. Martínez-Castro
    • , J. A. Matthews
    • , P. Miranda-Romagnoli
    • , E. Moreno
    • , M. Mostafá
    • , A. Nayerhoda
    • , L. Nellen
    • , M. Newbold
    • , M. U. Nisa
    • , R. Noriega-Papaqui
    • , J. Pretz
    • , E. G. Pérez-Pérez
    • , Z. Ren
    • , C. D. Rho
    • , C. Rivière
    • , D. Rosa-González
    • , M. Rosenberg
    • , E. Ruiz-Velasco
    • , F. Salesa Greus
    • , A. Sandoval
    • , M. Schneider
    • , H. Schoorlemmer
    • , M. Seglar Arroyo
    • , G. Sinnis
    • , A. J. Smith
    • , R. W. Springer
    • , P. Surajbali
    • , I. Taboada
    • , O. Tibolla
    • , K. Tollefson
    • , I. Torres
    • , G. Vianello
    • , L. Villaseñor
    • , T. Weisgarber
    • , F. Werner
    • , S. Westerhoff
    • , J. Wood
    • , T. Yapici
    • , G. Yodh
    • , A. Zepeda
    • , H. Zhang
    •  & H. Zhou
  • Letter |

    Time-asymmetric light transmission over the entire optical communications band is achieved using a silicon photonic structure with photonic modes that dynamically encircle an exceptional point in the optical domain.

    • Jae Woong Yoon
    • , Youngsun Choi
    • , Choloong Hahn
    • , Gunpyo Kim
    • , Seok Ho Song
    • , Ki-Yeon Yang
    • , Jeong Yub Lee
    • , Yongsung Kim
    • , Chang Seung Lee
    • , Jai Kwang Shin
    • , Hong-Seok Lee
    •  & Pierre Berini
  • Letter |

    The topological magnet Fe3Sn2 exhibits a giant nematic energy shift of a many-body electronic state, demonstrating anisotropic spin–orbit tunability.

    • Jia-Xin Yin
    • , Songtian S. Zhang
    • , Hang Li
    • , Kun Jiang
    • , Guoqing Chang
    • , Bingjing Zhang
    • , Biao Lian
    • , Cheng Xiang
    • , Ilya Belopolski
    • , Hao Zheng
    • , Tyler A. Cochran
    • , Su-Yang Xu
    • , Guang Bian
    • , Kai Liu
    • , Tay-Rong Chang
    • , Hsin Lin
    • , Zhong-Yi Lu
    • , Ziqiang Wang
    • , Shuang Jia
    • , Wenhong Wang
    •  & M. Zahid Hasan
  • Letter |

    An organic copolymer with compositionally tailored tacticity exhibits behaviour reminiscent of a morphotropic phase boundary, with an intramolecular order-to-disorder transition in the crystalline phase and a very large piezoelectric coefficient.

    • Yang Liu
    • , Haibibu Aziguli
    • , Bing Zhang
    • , Wenhan Xu
    • , Wenchang Lu
    • , J. Bernholc
    •  & Qing Wang
  • Letter |

    Chip-scale lithium niobate electro-optic modulators that rapidly convert electrical to optical signals and use CMOS-compatible voltages could prove useful in optical communication networks, microwave photonic systems and photonic computation.

    • Cheng Wang
    • , Mian Zhang
    • , Xi Chen
    • , Maxime Bertrand
    • , Amirhassan Shams-Ansari
    • , Sethumadhavan Chandrasekhar
    • , Peter Winzer
    •  & Marko Lončar
  • Letter |

    This approach introduces an aryl substituent to the α-carbon of amino acids without a transition-metal catalyst, and uses the inherent chirality of the amino acid itself as the source of asymmetry.

    • Daniel J. Leonard
    • , John W. Ward
    •  & Jonathan Clayden
  • Letter |

    Widespread but contrasting delayed responses of ecosystem productivity to spring warmth across northern ecosystems is inferred from satellite data, with higher areal fractions of adverse effects than beneficial effects.

    • Wolfgang Buermann
    • , Matthias Forkel
    • , Michael O’Sullivan
    • , Stephen Sitch
    • , Pierre Friedlingstein
    • , Vanessa Haverd
    • , Atul K. Jain
    • , Etsushi Kato
    • , Markus Kautz
    • , Sebastian Lienert
    • , Danica Lombardozzi
    • , Julia E. M. S. Nabel
    • , Hanqin Tian
    • , Andrew J. Wiltshire
    • , Dan Zhu
    • , William K. Smith
    •  & Andrew D. Richardson
  • Letter |

    A silcrete flake with a 73,000-year-old cross-hatched ochre drawing, from Blombos Cave, South Africa, demonstrates that early Homo sapiens used a range of media and techniques to produce graphic representations.

    • Christopher S. Henshilwood
    • , Francesco d’Errico
    • , Karen L. van Niekerk
    • , Laure Dayet
    • , Alain Queffelec
    •  & Luca Pollarolo
  • Letter |

    DEET interferes selectively with chemotaxis of Caenorhabditis elegans nematodes, and mutations in the str-217 gene or silencing of the pair of chemosensory neurons that express it makes worms DEET-resistant.

    • Emily J. Dennis
    • , May Dobosiewicz
    • , Xin Jin
    • , Laura B. Duvall
    • , Philip S. Hartman
    • , Cornelia I. Bargmann
    •  & Leslie B. Vosshall
  • Letter |

    In mouse and human liver models, blood vessel perfusion and mechanical stretching release angiocrine signals from endothelial cells that lead to hepatocyte survival and liver growth.

    • Linda Lorenz
    • , Jennifer Axnick
    • , Tobias Buschmann
    • , Carina Henning
    • , Sofia Urner
    • , Shentong Fang
    • , Harri Nurmi
    • , Nicole Eichhorst
    • , Richard Holtmeier
    • , Kálmán Bódis
    • , Jong-Hee Hwang
    • , Karsten Müssig
    • , Daniel Eberhard
    • , Jörg Stypmann
    • , Oliver Kuss
    • , Michael Roden
    • , Kari Alitalo
    • , Dieter Häussinger
    •  & Eckhard Lammert
  • Letter |

    A periosteal stem cell specialized in intramembranous bone formation has been identified and was found to be essential for normal bone development and fracture healing.

    • Shawon Debnath
    • , Alisha R. Yallowitz
    • , Jason McCormick
    • , Sarfaraz Lalani
    • , Tuo Zhang
    • , Ren Xu
    • , Na Li
    • , Yifang Liu
    • , Yeon Suk Yang
    • , Mark Eiseman
    • , Jae-Hyuck Shim
    • , Meera Hameed
    • , John H. Healey
    • , Mathias P. Bostrom
    • , Dan Avi Landau
    •  & Matthew B. Greenblatt
  • Letter |

    The Gram-positive Listeria monocytogenes pathogen possesses a distinctive extracellular electron transfer mechanism, which is probably present in numerous ecologically diverse species of the Firmcutes phylum.

    • Samuel H. Light
    • , Lin Su
    • , Rafael Rivera-Lugo
    • , Jose A. Cornejo
    • , Alexander Louie
    • , Anthony T. Iavarone
    • , Caroline M. Ajo-Franklin
    •  & Daniel A. Portnoy

Amendments & Corrections

Collections

  • Focal Point |

    Kobe

  • Spotlight |

    Faculty

    Beating the odds to secure a permanent contract. Six early-career researchers offer advice on how to secure a permanent contract in academia, and then make the most of it.
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