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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 540 Number 7631 pp7-162

1 December 2016

About the cover

Malignant germ cells with loss of heterozygosity undergoing apoptosis. Tumours formed from germ cells — those cells that develop in the embryo to become the cells of the reproductive system — tend to be more sensitive to chemotherapy than are many other adult cancers. To establish the basis for this chemosensitivity and the drivers of clinical resistance, Eliezer Van Allen, Christopher Sweeney and colleagues performed clinical whole-exome and transcriptome sequencing of germ-cell tumours from patients with various clinical outcomes, including the very rare case of death from germ-cell tumours. They find that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, and for mutations in KRAS, and have high mitochondrial priming. This work provides insights into chemosensitivity and the evolution of chemoresistance in germ-cell tumours. Cover: Ella Marushchenko & Elina Korobenko (Ella Maru Studio, Inc.)

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Technology Features

  • Metabolomics: Small molecules, single cells

    Sensitive mass spectrometry and innovative cell-sampling techniques allow researchers to profile metabolites in single cells, but the field is still in its infancy.

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Brief Communications Arising

  • Safikhani et al. reply

    • Zhaleh Safikhani
    • Nehme El-Hachem
    • Petr Smirnov
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    • Anna Goldenberg
    • Nicolai J. Birkbak
    • Andrew H. Beck
    • Hugo J. W. L. Aerts
    • John Quackenbush
    • Benjamin Haibe-Kains
  • Consistency in drug response profiling

    • John Patrick Mpindi
    • Bhagwan Yadav
    • Päivi Östling
    • Prson Gautam
    • Disha Malani
    • Astrid Murumägi
    • Akira Hirasawa
    • Sara Kangaspeska
    • Krister Wennerberg
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    • Zhaleh Safikhani
    • Nehme El-Hachem
    • Petr Smirnov
    • Mark Freeman
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    • Nicolai J. Birkbak
    • Andrew H. Beck
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    • John Quackenbush
    • Benjamin Haibe-Kains
  • Drug response consistency in CCLE and CGP

    • Mehdi Bouhaddou
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    • Eric A. Riesel
    • Emilce Carrasco
    • Hadassa Y. Holzapfel
    • DeAnalisa C. Jones
    • Gregory R. Smith
    • Alan D. Stern
    • Sulaiman S. Somani
    • T. Victoria Thompson
    • Marc R. Birtwistle
  • Safikhani et al. reply

    • Zhaleh Safikhani
    • Nehme El-Hachem
    • Petr Smirnov
    • Mark Freeman
    • Anna Goldenberg
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    • Andrew H. Beck
    • Hugo J. W. L. Aerts
    • John Quackenbush
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  • Stem cells and interspecies chimaeras

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    • Henry T. Greely
    • Rudolf Jaenisch
    • Hiromitsu Nakauchi
    • Janet Rossant
    • Juan Carlos Izpisua Belmonte

    A comprehensive review into mammalian interspecies chimaeras, documenting the advances that have occurred alongside developments in stem-cell biology and assessing the future of the field, including any possible ethical and legal issues.

  • Organization and functions of mGlu and GABAB receptor complexes

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    • Bernhard Bettler

    This Review discusses current knowledge of the structure, function and interactions of the metabotropic glutamate and GABAB receptors and the potential to target receptor subunits for future therapeutic intervention in neurological and mental health disorders.


  • The genomic basis of circadian and circalunar timing adaptations in a midgeOpen

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    • Florian Heyd
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    • Kristin Tessmar-Raible

    Genomic and molecular analyses of Clunio marinus timing strains suggest that modulation of alternative splicing of Ca2+/calmodulin-dependent kinase II represents a mechanism for evolutionary adaptation of circadian timing.

  • Correcting mitochondrial fusion by manipulating mitofusin conformations

    • Antonietta Franco
    • Richard N. Kitsis
    • Julie A. Fleischer
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    • Guohua Gong
    • Nikolaos Biris
    • Ann Benz
    • Nir Qvit
    • Sara K. Donnelly
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    • Steven Mennerick
    • Louis Hodgson
    • Daria Mochly-Rosen
    • Gerald W. Dorn II

    Specific intramolecular interactions of mitofusin 2 amino acid sequences either constrain or permit mitochondrial fusion and the addition of short peptides matching these sequences stabilize the fusion-constrained or fusion-permissive form, thus inhibiting or promoting mitochondrial fusion.

  • The pathway to GTPase activation of elongation factor SelB on the ribosome

    • Niels Fischer
    • Piotr Neumann
    • Lars V. Bock
    • Cristina Maracci
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    • Alena Paleskava
    • Andrey L. Konevega
    • Gunnar F Schröder
    • Helmut Grubmüller
    • Ralf Ficner
    • Marina V. Rodnina
    • Holger Stark

    The structures of several states on the pathway of SelB-mediated delivery of selenocysteine-specific tRNA to the ribosome in Escherichia coli reveal the mechanism of UGA stop codon recoding to selenocysteine and show how codon recognition triggers activation of translational GTPases.


  • Reorientation of Sputnik Planitia implies a subsurface ocean on Pluto

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    • D. P. Hamilton
    • W. B. McKinnon
    • P. M. Schenk
    • R. P. Binzel
    • C. J. Bierson
    • R. A. Beyer
    • J. M. Moore
    • S. A. Stern
    • H. A. Weaver
    • C. B. Olkin
    • L. A. Young
    • K. E. Smith
    • New Horizons Geology, Geophysics & Imaging Theme Team

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  • The rapid formation of Sputnik Planitia early in Pluto’s history

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    • J. M. Moore
    • L. A. Young
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    Modelling suggests that the icy region on Pluto known as Sputnik Planitia formed shortly after Charon did and has since been stable, with its latitude corresponding to a minimum in annual solar illumination and its longitude determined by tidal forces from Charon.

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  • Ghost imaging with atoms

    • R. I. Khakimov
    • B. M. Henson
    • D. K. Shin
    • S. S. Hodgman
    • R. G. Dall
    • K. G. H. Baldwin
    • A. G. Truscott

    Ghost imaging is demonstrated using beams of correlated pairs of ultracold helium atoms, rather than photons, yielding a reconstructed image with submillimetre resolution.

  • Quantifying global soil carbon losses in response to warming

    • T. W. Crowther
    • K. E. O. Todd-Brown
    • C. W. Rowe
    • W. R. Wieder
    • J. C. Carey
    • M. B. Machmuller
    • B. L. Snoek
    • S. Fang
    • G. Zhou
    • S. D. Allison
    • J. M. Blair
    • S. D. Bridgham
    • A. J. Burton
    • Y. Carrillo
    • P. B. Reich
    • J. S. Clark
    • A. T. Classen
    • F. A. Dijkstra
    • B. Elberling
    • B. A. Emmett
    • M. Estiarte
    • S. D. Frey
    • J. Guo
    • J. Harte
    • L. Jiang
    • B. R. Johnson
    • G. Kröel-Dulay
    • K. S. Larsen
    • H. Laudon
    • J. M. Lavallee
    • Y. Luo
    • M. Lupascu
    • L. N. Ma
    • S. Marhan
    • A. Michelsen
    • J. Mohan
    • S. Niu
    • E. Pendall
    • J. Peñuelas
    • L. Pfeifer-Meister
    • C. Poll
    • S. Reinsch
    • L. L. Reynolds
    • I. K. Schmidt
    • S. Sistla
    • N. W. Sokol
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    A compilation of global soil carbon data from field experiments provides empirical evidence that warming-induced net losses of soil carbon could accelerate climate change.

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  • Unexpected diversity in socially synchronized rhythms of shorebirds

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    • Mihai Valcu
    • Adriaan M. Dokter
    • Alexei G. Dondua
    • András Kosztolányi
    • Anne L. Rutten
    • Barbara Helm
    • Brett K. Sandercock
    • Bruce Casler
    • Bruno J. Ens
    • Caleb S. Spiegel
    • Chris J. Hassell
    • Clemens Küpper
    • Clive Minton
    • Daniel Burgas
    • David B. Lank
    • David C. Payer
    • Egor Y. Loktionov
    • Erica Nol
    • Eunbi Kwon
    • Fletcher Smith
    • H. River Gates
    • Hana Vitnerová
    • Hanna Prüter
    • James A. Johnson
    • James J. H. St Clair
    • Jean-François Lamarre
    • Jennie Rausch
    • Jeroen Reneerkens
    • Jesse R. Conklin
    • Joanna Burger
    • Joe Liebezeit
    • Joël Bêty
    • Jonathan T. Coleman
    • Jordi Figuerola
    • Jos C. E. W. Hooijmeijer
    • José A. Alves
    • Joseph A. M. Smith
    • Karel Weidinger
    • Kari Koivula
    • Ken Gosbell
    • Klaus-Michael Exo
    • Larry Niles
    • Laura Koloski
    • Laura McKinnon
    • Libor Praus
    • Marcel Klaassen
    • Marie-Andrée Giroux
    • Martin Sládeček
    • Megan L. Boldenow
    • Michael I. Goldstein
    • Miroslav Šálek
    • Nathan Senner
    • Nelli Rönkä
    • Nicolas Lecomte
    • Olivier Gilg
    • Orsolya Vincze
    • Oscar W. Johnson
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    • Paul F. Woodard
    • Pavel S. Tomkovich
    • Phil F. Battley
    • Rebecca Bentzen
    • Richard B. Lanctot
    • Ron Porter
    • Sarah T. Saalfeld
    • Scott Freeman
    • Stephen C. Brown
    • Stephen Yezerinac
    • Tamás Székely
    • Tomás Montalvo
    • Theunis Piersma
    • Vanessa Loverti
    • Veli-Matti Pakanen
    • Wim Tijsen
    • Bart Kempenaers

    Socially synchronized rhythms in shorebirds were assessed during biparental incubation under natural circumstances and were exceptionally diverse, often not following the 24-h day, whereby risk of predation, not starvation, determined some of the variation in incubation rhythms.

    See also
  • Genomic evolution and chemoresistance in germ-cell tumours

    • Amaro Taylor-Weiner
    • Travis Zack
    • Elizabeth O’Donnell
    • Jennifer L. Guerriero
    • Brandon Bernard
    • Anita Reddy
    • G. Celine Han
    • Saud AlDubayan
    • Ali Amin-Mansour
    • Steven E. Schumacher
    • Kevin Litchfield
    • Clare Turnbull
    • Stacey Gabriel
    • Rameen Beroukhim
    • Gad Getz
    • Scott L. Carter
    • Michelle S. Hirsch
    • Anthony Letai
    • Christopher Sweeney
    • Eliezer M Van Allen

    Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

  • Inhibition of mTOR induces a paused pluripotent state

    • Aydan Bulut-Karslioglu
    • Steffen Biechele
    • Hu Jin
    • Trisha A. Macrae
    • Miroslav Hejna
    • Marina Gertsenstein
    • Jun S. Song
    • Miguel Ramalho-Santos

    Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.

  • RIPK1 inhibits ZBP1-driven necroptosis during development

    • Kim Newton
    • Katherine E. Wickliffe
    • Allie Maltzman
    • Debra L. Dugger
    • Andreas Strasser
    • Victoria C. Pham
    • Jennie R. Lill
    • Merone Roose-Girma
    • Søren Warming
    • Margaret Solon
    • Hai Ngu
    • Joshua D. Webster
    • Vishva M. Dixit

    In the absence of RIPK1, ZBP1 engages RIPK3 in a RHIM-dependent manner and acts as a critical activator of RIPK3/MLKL-dependent necroptosis.

    See also
  • The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

    • Naama Aviram
    • Tslil Ast
    • Elizabeth A. Costa
    • Eric C. Arakel
    • Silvia G. Chuartzman
    • Calvin H. Jan
    • Sarah Haßdenteufel
    • Johanna Dudek
    • Martin Jung
    • Stefan Schorr
    • Richard Zimmermann
    • Blanche Schwappach
    • Jonathan S. Weissman
    • Maya Schuldiner

    Experiments in yeast cells show that three proteins—Snd1, Snd2 and Snd3—provide an alternative pathway for targeting of cellular proteins to the endoplasmic reticulum.

    See also
  • In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

    • Keiichiro Suzuki
    • Yuji Tsunekawa
    • Reyna Hernandez-Benitez
    • Jun Wu
    • Jie Zhu
    • Euiseok J. Kim
    • Fumiyuki Hatanaka
    • Mako Yamamoto
    • Toshikazu Araoka
    • Zhe Li
    • Masakazu Kurita
    • Tomoaki Hishida
    • Mo Li
    • Emi Aizawa
    • Shicheng Guo
    • Song Chen
    • April Goebl
    • Rupa Devi Soligalla
    • Jing Qu
    • Tingshuai Jiang
    • Xin Fu
    • Maryam Jafari
    • Concepcion Rodriguez Esteban
    • W. Travis Berggren
    • Jeronimo Lajara
    • Estrella Nuñez-Delicado
    • Pedro Guillen
    • Josep M. Campistol
    • Fumio Matsuzaki
    • Guang-Hui Liu
    • Pierre Magistretti
    • Kun Zhang
    • Edward M. Callaway
    • Kang Zhang
    • Juan Carlos Izpisua Belmonte

    A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.