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Current Issue of Nature


Volume 575 Issue 7784, 28 November 2019

Volume 575 Issue 7784, 28 November 2019

Twisted tale

The cover image shows tau protein (blue) accumulating inside neurons. Alongside amyloid-β, tau is believed to play a significant part in Alzheimer’s disease. Whereas amyloid-β accumulates in plaques, hyperphosphorylated tau aggregates in neurofibrillary tangles; these plaques and tangles contribute to neurodegeneration and cognitive decline. Activation in microglia of the NLRP3 inflammasome, a protein complex that is part of the body’s natural defences, is essential for amyloid-β plaque formation. In this week’s issue, Michael Heneka and his colleagues reveal that the NLRP3 inflammasome also helps to drive the formation of tau tangles. The team shows that tau tangles develop downstream of amyloid-β activating microglia and the NLRP3 inflammasome, lending support to the amyloid-cascade hypothesis in Alzheimer‘s disease. The researchers also find that tau itself can prompt activation of the inflammasome, hinting that there may be broader implications for other neurodegenerative diseases.

Cover image: Pixeldust Studios

This Week

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Work

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    Nature’s biennial doctoral-student survey reveals struggles for work–life balance, career guidance and emotional support.

    • Chris Woolston
    •  & Sarah O’Meara
  • Technology Feature

  • Where I Work

  • Where I Work |

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    • Virginia Gewin

Research

    News & Views

  • News & Views |

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    • Brent R. Stockwell
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    • Xin-Ming Hu
    •  & Kim Daasbjerg
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    •  & Jue D. Wang
  • News & Views |

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    •  & Beatriz Noheda
  • News & Views |

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    • Henry Mattingly
    •  & Thierry Emonet
  • News & Views |

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    • Alexander L. Efros
  • Perspective

  • Perspective |

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    • Kaushik Roy
    • , Akhilesh Jaiswal
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  • Articles

  • Article |

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    • Jifeng Liu
    • , Haotong Zhang
    • , Andrew W. Howard
    • , Zhongrui Bai
    • , Youjun Lu
    • , Roberto Soria
    • , Stephen Justham
    • , Xiangdong Li
    • , Zheng Zheng
    • , Tinggui Wang
    • , Krzysztof Belczynski
    • , Jorge Casares
    • , Wei Zhang
    • , Hailong Yuan
    • , Yiqiao Dong
    • , Yajuan Lei
    • , Howard Isaacson
    • , Song Wang
    • , Yu Bai
    • , Yong Shao
    • , Qing Gao
    • , Yilun Wang
    • , Zexi Niu
    • , Kaiming Cui
    • , Chuanjie Zheng
    • , Xiaoyong Mu
    • , Lan Zhang
    • , Wei Wang
    • , Alexander Heger
    • , Zhaoxiang Qi
    • , Shilong Liao
    • , Mario Lattanzi
    • , Wei-Min Gu
    • , Junfeng Wang
    • , Jianfeng Wu
    • , Lijing Shao
    • , Rongfeng Shen
    • , Xiaofeng Wang
    • , Joel Bregman
    • , Rosanne Di Stefano
    • , Qingzhong Liu
    • , Zhanwen Han
    • , Tianmeng Zhang
    • , Huijuan Wang
    • , Juanjuan Ren
    • , Junbo Zhang
    • , Jujia Zhang
    • , Xiaoli Wang
    • , Antonio Cabrera-Lavers
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    • , Matthias C. Löbl
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    • A. Marguerite
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    • , A. Aharon-Steinberg
    • , D. Halbertal
    • , K. Bagani
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  • Article |

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    • Yu-Ho Won
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    • , Dae-Young Chung
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  • Article |

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    • Yueshen Wu
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    •  & Hailiang Wang
  • Article |

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    • M. K. Roxy
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  • Article |

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    • Deborah J. Thompson
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    • , Felix R. Day
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    • , Marcus Danielsson
    • , Hanna Davies
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    • , Douglas F. Easton
    • , Victoria A. Fisher
    • , Florian Zink
    • , Richard S. Houlston
    • , Martin Ingelsson
    • , Siddhartha Kar
    • , Nicola D. Kerrison
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    • , Ragnar P. Kristjansson
    • , Philip J. Law
    • , Rong Li
    • , Chey Loveday
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    • , Steven A. McCarroll
    • , Yoshinori Murakami
    • , Anna Murray
    • , Pawel Olszewski
    • , Edyta Rychlicka-Buniowska
    • , Robert A. Scott
    • , Unnur Thorsteinsdottir
    • , Ian Tomlinson
    • , Behrooz Torabi Moghadam
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    • , Daniel F. Gudbjartsson
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    • Weirong Liu
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    • Christina Ising
    • , Carmen Venegas
    • , Shuangshuang Zhang
    • , Hannah Scheiblich
    • , Susanne V. Schmidt
    • , Ana Vieira-Saecker
    • , Stephanie Schwartz
    • , Shadi Albasset
    • , Róisín M. McManus
    • , Dario Tejera
    • , Angelika Griep
    • , Francesco Santarelli
    • , Frederic Brosseron
    • , Sabine Opitz
    • , James Stunden
    • , Maximilian Merten
    • , Rakez Kayed
    • , Douglas T. Golenbock
    • , David Blum
    • , Eicke Latz
    • , Luc Buée
    •  & Michael T. Heneka
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    The bacterium Pseudomonas aeruginosa attacks competing bacteria using the toxin Tas1, which pyrophosphorylates adenosine nucleotides to generate (p)ppApp, thereby depleting ATP and disrupting multiple cellular functions.

    • Shehryar Ahmad
    • , Boyuan Wang
    • , Matthew D. Walker
    • , Hiu-Ki R. Tran
    • , Peter J. Stogios
    • , Alexei Savchenko
    • , Robert A. Grant
    • , Andrew G. McArthur
    • , Michael T. Laub
    •  & John C. Whitney
  • Article |

    Alternative cell death pathways are revealed in the absence of caspase-8-dependent apoptosis and MLKL-dependent necroptosis.

    • Kim Newton
    • , Katherine E. Wickliffe
    • , Allie Maltzman
    • , Debra L. Dugger
    • , Rohit Reja
    • , Yue Zhang
    • , Merone Roose-Girma
    • , Zora Modrusan
    • , Meredith S. Sagolla
    • , Joshua D. Webster
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  • Article |

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    • Melanie Fritsch
    • , Saskia D. Günther
    • , Robin Schwarzer
    • , Marie-Christine Albert
    • , Fabian Schorn
    • , J. Paul Werthenbach
    • , Lars M. Schiffmann
    • , Neil Stair
    • , Hannah Stocks
    • , Jens M. Seeger
    • , Mohamed Lamkanfi
    • , Martin Krönke
    • , Manolis Pasparakis
    •  & Hamid Kashkar
  • Article |

    A synthetic lethal CRISPR–Cas9 screen identifies ferroptosis suppressor protein 1 as a key ferroptosis-resistance factor, the expression of which correlates with ferroptosis resistance in hundreds of cancer cell lines.

    • Kirill Bersuker
    • , Joseph M. Hendricks
    • , Zhipeng Li
    • , Leslie Magtanong
    • , Breanna Ford
    • , Peter H. Tang
    • , Melissa A. Roberts
    • , Bingqi Tong
    • , Thomas J. Maimone
    • , Roberto Zoncu
    • , Michael C. Bassik
    • , Daniel K. Nomura
    • , Scott J. Dixon
    •  & James A. Olzmann
  • Article |

    In the absence of GPX4, FSP1 regenerates ubiquinol from the oxidized form, ubiquinone, using NAD(P)H and suppresses phospholipid peroxidation and ferroptosis in cells.

    • Sebastian Doll
    • , Florencio Porto Freitas
    • , Ron Shah
    • , Maceler Aldrovandi
    • , Milene Costa da Silva
    • , Irina Ingold
    • , Andrea Goya Grocin
    • , Thamara Nishida Xavier da Silva
    • , Elena Panzilius
    • , Christina H. Scheel
    • , André Mourão
    • , Katalin Buday
    • , Mami Sato
    • , Jonas Wanninger
    • , Thibaut Vignane
    • , Vaishnavi Mohana
    • , Markus Rehberg
    • , Andrew Flatley
    • , Aloys Schepers
    • , Andreas Kurz
    • , Daniel White
    • , Markus Sauer
    • , Michael Sattler
    • , Edward William Tate
    • , Werner Schmitz
    • , Almut Schulze
    • , Valerie O’Donnell
    • , Bettina Proneth
    • , Grzegorz M. Popowicz
    • , Derek A. Pratt
    • , José Pedro Friedmann Angeli
    •  & Marcus Conrad
  • Article |

    Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.

    • Sihan Wu
    • , Kristen M. Turner
    • , Nam Nguyen
    • , Ramya Raviram
    • , Marcella Erb
    • , Jennifer Santini
    • , Jens Luebeck
    • , Utkrisht Rajkumar
    • , Yarui Diao
    • , Bin Li
    • , Wenjing Zhang
    • , Nathan Jameson
    • , M. Ryan Corces
    • , Jeffrey M. Granja
    • , Xingqi Chen
    • , Ceyda Coruh
    • , Armen Abnousi
    • , Jack Houston
    • , Zhen Ye
    • , Rong Hu
    • , Miao Yu
    • , Hoon Kim
    • , Julie A. Law
    • , Roel G. W. Verhaak
    • , Ming Hu
    • , Frank B. Furnari
    • , Howard Y. Chang
    • , Bing Ren
    • , Vineet Bafna
    •  & Paul S. Mischel

Amendments & Corrections

  • Author Correction |

    • P. H. Barry
    • , J. M. de Moor
    • , D. Giovannelli
    • , M. Schrenk
    • , D. R. Hummer
    • , T. Lopez
    • , C. A. Pratt
    • , Y. Alpízar Segura
    • , A. Battaglia
    • , P. Beaudry
    • , G. Bini
    • , M. Cascante
    • , G. d’Errico
    • , M. di Carlo
    • , D. Fattorini
    • , K. Fullerton
    • , E. Gazel
    • , G. González
    • , S. A. Halldórsson
    • , T. Ilanko
    • , K. Iacovino
    • , J. T. Kulongoski
    • , E. Manini
    • , M. Martínez
    • , H. Miller
    • , M. Nakagawa
    • , S. Ono
    • , S. Patwardhan
    • , C. J. Ramírez
    • , F. Regoli
    • , F. Smedile
    • , S. Turner
    • , C. Vetriani
    • , M. Yücel
    • , C. J. Ballentine
    • , T. P. Fischer
    • , D. R. Hilton
    •  & K. G. Lloyd

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