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Current Issue of Nature


Volume 563 Issue 7731, 15 November 2018

Volume 563 Issue 7731, 15 November 2018

Volume 563 Issue 7731

Secrets of pregnancy

The cellular changes that occur in the early stages of pregnancy lay the foundations for reproductive success. In this week’s issue, Sarah Teichmann and her colleagues present a single-cell atlas of the interface that forms between mother and the developing fetus. The researchers performed RNA sequencing on some 70,000 cells from first-trimester placentas with matched cells from the mother’s blood and uterus. They uncovered remarkable complexity in the cell types and the cell–cell communication networks that form to support the growing fetus. The network shows that the mother’s immune system adapts to support the placenta as it implants and develops in the wall of the uterus. The atlas should help identify the causes of problems in pregnancy such as pre-eclampsia and stillbirth.

Cover image: Ania Hupalowska

This Week

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Research

    News & Views

  • News & Views Forum |

    Adult tissues must maintain themselves and regenerate after damage. But are these crucial functions mediated by dedicated populations of stem cells, or do differentiated cells adopt stem-cell-like properties according to an organ’s needs? Here, two scientists present evidence from both sides of the debate.

    • Pura Muñoz-Cánoves
    •  & Meritxell Huch
  • News & Views |

    The detection of a low-mass exoplanet on a relatively wide orbit has implications for models of planetary formation and evolution, and could open the door to a new era of exoplanet characterization.

    • Rodrigo F. Díaz
  • News & Views |

    A gut bacterium has been found to modulate locomotor activity in the fruit fly Drosophila melanogaster. This effect is mediated by the level of a sugar and the activity of neurons that produce the molecule octopamine.

    • Angela E. Douglas
  • News & Views |

    Antiviral drugs prevent HIV from replicating, but the virus can hide in the cells of infected individuals in a non-replicating, latent form. A two-pronged approach to target this latent virus shows promise in monkeys.

    • Sharon R. Lewin
  • News & Views |

    What Nature said 50 and 100 years ago about record-breaking telescopes and the end of the First World War.

  • News & Views |

    A tectonic plate descending into the Mariana Trench carries sea water deep into Earth’s interior. It seems that much more water enters Earth at this location than was thought — with implications for the global water budget.

    • Donna J. Shillington
  • News & Views |

    RNA sequencing of thousands of single cells located at the interface between mother and fetus in early pregnancy reveals remarkable complexity in the cell types and regulatory networks that support reproduction.

    • Sumati Rajagopalan
    •  & Eric O. Long
  • Articles

  • Article |

    Climate model simulations reveal that recent destructive tropical cyclones would have been equally intense in terms of wind speed but would have produced less rainfall if these events had occurred in pre-industrial climates, and in future climates they would have greater wind speeds and rainfall.

    • Christina M. Patricola
    •  & Michael F. Wehner
  • Article |

    Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • , Mirjana Efremova
    • , Rachel A. Botting
    • , Margherita Y. Turco
    • , Miquel Vento-Tormo
    • , Kerstin B. Meyer
    • , Jong-Eun Park
    • , Emily Stephenson
    • , Krzysztof Polański
    • , Angela Goncalves
    • , Lucy Gardner
    • , Staffan Holmqvist
    • , Johan Henriksson
    • , Angela Zou
    • , Andrew M. Sharkey
    • , Ben Millar
    • , Barbara Innes
    • , Laura Wood
    • , Anna Wilbrey-Clark
    • , Rebecca P. Payne
    • , Martin A. Ivarsson
    • , Steve Lisgo
    • , Andrew Filby
    • , David H. Rowitch
    • , Judith N. Bulmer
    • , Gavin J. Wright
    • , Michael J. T. Stubbington
    • , Muzlifah Haniffa
    • , Ashley Moffett
    •  & Sarah A. Teichmann
  • Article |

    Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD+ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.

    • Elena Katsyuba
    • , Adrienne Mottis
    • , Marika Zietak
    • , Francesca De Franco
    • , Vera van der Velpen
    • , Karim Gariani
    • , Dongryeol Ryu
    • , Lucia Cialabrini
    • , Olli Matilainen
    • , Paride Liscio
    • , Nicola Giacchè
    • , Nadine Stokar-Regenscheit
    • , David Legouis
    • , Sophie de Seigneux
    • , Julijana Ivanisevic
    • , Nadia Raffaelli
    • , Kristina Schoonjans
    • , Roberto Pellicciari
    •  & Johan Auwerx
  • Article |

    In monkeys infected with an AIDS-like virus, a combination of a broadly neutralizing antibody and an immune stimulator during antiretroviral therapy suppressed viral rebound after antiretroviral drug discontinuation.

    • Erica N. Borducchi
    • , Jinyan Liu
    • , Joseph P. Nkolola
    • , Anthony M. Cadena
    • , Wen-Han Yu
    • , Stephanie Fischinger
    • , Thomas Broge
    • , Peter Abbink
    • , Noe B. Mercado
    • , Abishek Chandrashekar
    • , David Jetton
    • , Lauren Peter
    • , Katherine McMahan
    • , Edward T. Moseley
    • , Elena Bekerman
    • , Joseph Hesselgesser
    • , Wenjun Li
    • , Mark G. Lewis
    • , Galit Alter
    • , Romas Geleziunas
    •  & Dan H. Barouch
  • Letters

  • Letter |

    Analysis of 20 years of observations of Barnard’s star from seven facilities reveals a signal with a period of 233 days that is indicative of a companion planet.

    • I. Ribas
    • , M. Tuomi
    • , A. Reiners
    • , R. P. Butler
    • , J. C. Morales
    • , M. Perger
    • , S. Dreizler
    • , C. Rodríguez-López
    • , J. I. González Hernández
    • , A. Rosich
    • , F. Feng
    • , T. Trifonov
    • , S. S. Vogt
    • , J. A. Caballero
    • , A. Hatzes
    • , E. Herrero
    • , S. V. Jeffers
    • , M. Lafarga
    • , F. Murgas
    • , R. P. Nelson
    • , E. Rodríguez
    • , J. B. P. Strachan
    • , L. Tal-Or
    • , J. Teske
    • , B. Toledo-Padrón
    • , M. Zechmeister
    • , A. Quirrenbach
    • , P. J. Amado
    • , M. Azzaro
    • , V. J. S. Béjar
    • , J. R. Barnes
    • , Z. M. Berdiñas
    • , J. Burt
    • , G. Coleman
    • , M. Cortés-Contreras
    • , J. Crane
    • , S. G. Engle
    • , E. F. Guinan
    • , C. A. Haswell
    • , Th. Henning
    • , B. Holden
    • , J. Jenkins
    • , H. R. A. Jones
    • , A. Kaminski
    • , M. Kiraga
    • , M. Kürster
    • , M. H. Lee
    • , M. J. López-González
    • , D. Montes
    • , J. Morin
    • , A. Ofir
    • , E. Pallé
    • , R. Rebolo
    • , S. Reffert
    • , A. Schweitzer
    • , W. Seifert
    • , S. A. Shectman
    • , D. Staab
    • , R. A. Street
    • , A. Suárez Mascareño
    • , Y. Tsapras
    • , S. X. Wang
    •  & G. Anglada-Escudé
  • Letter |

    Clock spectroscopy of ultracold strontium atoms in a three-dimensional optical lattice is used to observe the onset of multi-body interactions that result from the underlying pairwise interactions between atoms.

    • A. Goban
    • , R. B. Hutson
    • , G. E. Marti
    • , S. L. Campbell
    • , M. A. Perlin
    • , P. S. Julienne
    • , J. P. D’Incao
    • , A. M. Rey
    •  & J. Ye
  • Letter |

    Resonant inelastic X-ray scattering on electron-doped copper oxide superconductors reveals a three-dimensional charge collective mode, which has properties suggestive of the long-sought acoustic plasmon.

    • M. Hepting
    • , L. Chaix
    • , E. W. Huang
    • , R. Fumagalli
    • , Y. Y. Peng
    • , B. Moritz
    • , K. Kummer
    • , N. B. Brookes
    • , W. C. Lee
    • , M. Hashimoto
    • , T. Sarkar
    • , J.-F. He
    • , C. R. Rotundu
    • , Y. S. Lee
    • , R. L. Greene
    • , L. Braicovich
    • , G. Ghiringhelli
    • , Z. X. Shen
    • , T. P. Devereaux
    •  & W. S. Lee
  • Letter |

    Wildebeest, particularly during their long migrations under hot arid conditions, gain a considerable increase in range as a result of having highly efficient muscles.

    • Nancy A. Curtin
    • , Hattie L. A. Bartlam-Brooks
    • , Tatjana Y. Hubel
    • , John C. Lowe
    • , Anthony R. Gardner-Medwin
    • , Emily Bennitt
    • , Stephen J. Amos
    • , Maja Lorenc
    • , Timothy G. West
    •  & Alan M. Wilson
  • Letter |

    Dopamine in the medial prefrontal cortex modulates behavioural responses to aversive stimuli by increasing the signal-to-noise ratio of neurons projecting to the dorsal periaqueductal grey.

    • Caitlin M. Vander Weele
    • , Cody A. Siciliano
    • , Gillian A. Matthews
    • , Praneeth Namburi
    • , Ehsan M. Izadmehr
    • , Isabella C. Espinel
    • , Edward H. Nieh
    • , Evelien H. S. Schut
    • , Nancy Padilla-Coreano
    • , Anthony Burgos-Robles
    • , Chia-Jung Chang
    • , Eyal Y. Kimchi
    • , Anna Beyeler
    • , Romy Wichmann
    • , Craig P. Wildes
    •  & Kay M. Tye
  • Letter |

    Female Drosophila that lack a microbiota are hyperactive, and xylose isomerase from Lactobacillus brevis is sufficient to reverse this effect.

    • Catherine E. Schretter
    • , Jost Vielmetter
    • , Imre Bartos
    • , Zsuzsa Marka
    • , Szabolcs Marka
    • , Sulabha Argade
    •  & Sarkis K. Mazmanian
  • Letter |

    A structurally unusual zwitterionic metabolite, dimethylsulfoxonium propionate (DMSOP), is synthesized by several dimethylsulfoniopropionate-producing microalgae and marine bacteria and is readily metabolized into dimethylsulfoxide by marine bacteria, expanding our knowledge of the marine organosulfur cycle.

    • Kathleen Thume
    • , Björn Gebser
    • , Liang Chen
    • , Nils Meyer
    • , David J. Kieber
    •  & Georg Pohnert
  • Letter |

    A subclass of ribonucleotide reductase in Mycoplasma pathogens contains a stable radical formed from a modified tyrosine residue, overturning the presumed requirement for a dinuclear metal site in aerobic ribonucleotide reductase.

    • Vivek Srinivas
    • , Hugo Lebrette
    • , Daniel Lundin
    • , Yuri Kutin
    • , Margareta Sahlin
    • , Michael Lerche
    • , Jürgen Eirich
    • , Rui M. M. Branca
    • , Nicholas Cox
    • , Britt-Marie Sjöberg
    •  & Martin Högbom
  • Letter |

    Crystallography and spectroscopy are used to solve high-resolution structures of the intermediates of Kok’s S-state clock in photosystem II.

    • Jan Kern
    • , Ruchira Chatterjee
    • , Iris D. Young
    • , Franklin D. Fuller
    • , Louise Lassalle
    • , Mohamed Ibrahim
    • , Sheraz Gul
    • , Thomas Fransson
    • , Aaron S. Brewster
    • , Roberto Alonso-Mori
    • , Rana Hussein
    • , Miao Zhang
    • , Lacey Douthit
    • , Casper de Lichtenberg
    • , Mun Hon Cheah
    • , Dmitry Shevela
    • , Julia Wersig
    • , Ina Seuffert
    • , Dimosthenis Sokaras
    • , Ernest Pastor
    • , Clemens Weninger
    • , Thomas Kroll
    • , Raymond G. Sierra
    • , Pierre Aller
    • , Agata Butryn
    • , Allen M. Orville
    • , Mengning Liang
    • , Alexander Batyuk
    • , Jason E. Koglin
    • , Sergio Carbajo
    • , Sébastien Boutet
    • , Nigel W. Moriarty
    • , James M. Holton
    • , Holger Dobbek
    • , Paul D. Adams
    • , Uwe Bergmann
    • , Nicholas K. Sauter
    • , Athina Zouni
    • , Johannes Messinger
    • , Junko Yano
    •  & Vittal K. Yachandra
  • Letter |

    Cryo-electron microscopy structures of the ABCG2 protein in ATP- and substrate-bound states reveal the location of substrate binding, conformational changes required for substrate translocation and how inhibitors might be distinguished from substrates.

    • Ioannis Manolaridis
    • , Scott M. Jackson
    • , Nicholas M. I. Taylor
    • , Julia Kowal
    • , Henning Stahlberg
    •  & Kaspar P. Locher

Amendments & Corrections

Collections

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    Nanomedicine in Japan

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  • Nature Outlook |

    Lymphoma

    Each year, more than 400,000 people worldwide develop tumours of the lymphatic system (lymphoma), and around half that number die from the disease. Better treatments are especially being sought for non-Hodgkin’s lymphoma — the incidence of which is climbing but for which successful treatments are elusive.
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