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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 545 Number 7655 pp385-520

25 May 2017

About the cover

In this issue, Charles Swanton and his colleagues suggest that ‘liquid biopsies’ could be used for the early detection of a relapse after surgery for non-small-cell lung cancer. The researchers assessed the evolutionary dynamics of tumours surgically removed from participants in the TRACERx lung-cancer clinical study. They created phylogenetic trees to show how an individual’s tumour evolved and used that information as the basis for a blood test to look for circulating tumour DNA (ctDNA). This allowed the team to identify recurrence of the tumour around 70 days before it was identified in a routine clinical setting as well as providing insight into the metastatic branched evolutionary process. The results indicate how liquid biopsies might be applied in personalized medicine to improve cancer monitoring. Cover image: Jeroen Claus and Giovanni Panico/Phospho Biomedical Animation.

This Week



World View


Research Highlights


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    Books and Arts

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    • Haematopoietic stem and progenitor cells from human pluripotent stem cells

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      • William Schachterle
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      • Koji Shido
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      • Joseph M. Scandura
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      The authors reprogram in vitro endothelial cells from adult mice into engraftable haematopoietic stem cells that display single-cell and multilineage properties, are capable of long-term self-renewal and can reconstitute T cell adaptive immune function.

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      • Eva Grönroos
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      • Wenya Linda Bi
      • Fiona M. Fennessy
      • Nicole Sponer
      • Diana Johnson
      • Joanne Laycock
      • Seema Shafi
      • Justyna Czyzewska-Khan
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      • Tim Chambers
      • Nik Matthews
      • Samra Turajlic
      • Crispin Hiley
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      • Martin D. Forster
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      • Sam M. Janes
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      • Yvonne Summers
      • Dina Hafez
      • Ashwini Naik
      • Apratim Ganguly
      • Stephanie Kareht
      • Rajesh Shah
      • Leena Joseph
      • Anne Marie Quinn
      • Phil A. Crosbie
      • Babu Naidu
      • Gary Middleton
      • Gerald Langman
      • Simon Trotter
      • Marianne Nicolson
      • Hardy Remmen
      • Keith Kerr
      • Mahendran Chetty
      • Lesley Gomersall
      • Dean A. Fennell
      • Apostolos Nakas
      • Sridhar Rathinam
      • Girija Anand
      • Sajid Khan
      • Peter Russell
      • Veni Ezhil
      • Babikir Ismail
      • Melanie Irvin-Sellers
      • Vineet Prakash
      • Jason F. Lester
      • Malgorzata Kornaszewska
      • Richard Attanoos
      • Haydn Adams
      • Helen Davies
      • Dahmane Oukrif
      • Ayse U. Akarca
      • John A. Hartley
      • Helen L. Lowe
      • Sara Lock
      • Natasha Iles
      • Harriet Bell
      • Yenting Ngai
      • Greg Elgar
      • Zoltan Szallasi
      • Roland F. Schwarz
      • Javier Herrero
      • Aengus Stewart
      • Sergio A. Quezada
      • Karl S. Peggs
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      • Caroline Dive
      • C. Jimmy Lin
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      • Hugo J. W. L. Aerts
      • Allan Hackshaw
      • Jacqui A. Shaw
      • Bernhard G. Zimmermann
      • The TRACERx consortium
      • The PEACE consortium
      • Charles Swanton

      Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

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      • Matthew D. Hellmann
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      Epigenetic programming of T cells in solid tumours from a functional to a dysfunctional state occurs in two phases, and only the first phase is reversible.