This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 543 Number 7647 pp589-752

30 March 2017

About the cover

The cover shows an artist’s impression of cancer stem cells metastasizing through the blood stream. Cancer stem cells are thought to be the driving force behind tumour growth and metastatic dissemination, but experimental evidence is lacking for many types of cancer. Felipe de Sousa e Melo and his colleagues reveal that in colon cancer, plasticity renders Lgr5+ stem cells dispensable for primary tumour growth. When the researchers removed the cells from the system, they did not see the anticipated regression — instead tumours were maintained by Lgr5 stem cells. However, the team found that metastatic dissemination and growth in the liver was greatly impaired, signifying that Lgr5+ cancer stem cells are crucial for this process and so might be a target for managing metastatic disease. Cover image: Allison Bruce

This Week



World View

  • Brexit must preserve advisory networks

    Policymakers in charge of the United Kingdom’s withdrawal from the European Union have a duty to maintain benefits of collaboration, says James Wilsdon.

Seven Days


News in Focus




Books and Arts

  • Natural history: Backstage at the museum

    Richard Fortey questions the level of derring-do in an account of the life curatorial.

    • Review of Curators: Behind the Scenes of Natural History Museums
      Lance Grande
  • Metascience: Reproducibility blues

    Marcus Munafò enjoys a stinging survey of unreliable findings in biomedical research.

    • Review of Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
      Richard F. Harris
  • Language: Points, grunts and speaks

    Mark Pagel weighs up a study claiming that the origins of human language are rooted in gesture.

    • Review of The Truth about Language: What It Is and Where It Came From
      Michael C. Corballis
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.





  • Flexible working: Solo scientist

    Researchers who work for themselves can benefit from forming coalitions that provide both practical and psychological support.

    • Amber Dance

Career Briefs


naturejobs job listings and advertising features


  • Sofer Pete

    Evolution in action.

    • Tom Easton
    • Michael A. Burstein


Technology Feature




  • Exploiting non-covalent π interactions for catalyst design

    • Andrew J. Neel
    • Margaret J. Hilton
    • Matthew S. Sigman
    • F. Dean Toste

    Our increasing understanding of non-covalent interactions involving aromatic systems is reviewed, and the use of these insights in the design of small-molecule catalysts and enzymes is surveyed.

  • Using coherence to enhance function in chemical and biophysical systems

    • Gregory D. Scholes
    • Graham R. Fleming
    • Lin X. Chen
    • Alán Aspuru-Guzik
    • Andreas Buchleitner
    • David F. Coker
    • Gregory S. Engel
    • Rienk van Grondelle
    • Akihito Ishizaki
    • David M. Jonas
    • Jeff S. Lundeen
    • James K. McCusker
    • Shaul Mukamel
    • Jennifer P. Ogilvie
    • Alexandra Olaya-Castro
    • Mark A. Ratner
    • Frank C. Spano
    • K. Birgitta Whaley
    • Xiaoyang Zhu

    Coherence observed in chemical and biological systems suggests that even in the presence of disorder and noise the phenomenon may yield transformative ways for improving function.


  • Functional materials discovery using energy–structure–function maps

    • Angeles Pulido
    • Linjiang Chen
    • Tomasz Kaczorowski
    • Daniel Holden
    • Marc A. Little
    • Samantha Y. Chong
    • Benjamin J. Slater
    • David P. McMahon
    • Baltasar Bonillo
    • Chloe J. Stackhouse
    • Andrew Stephenson
    • Christopher M. Kane
    • Rob Clowes
    • Tom Hasell
    • Andrew I. Cooper
    • Graeme M. Day

    Energy–structure–function maps that describe the possible structures and properties of molecular crystals are developed, and these maps are used to guide the experimental discovery of porous materials with specific functions.

  • Capacity shortfalls hinder the performance of marine protected areas globally

    • David A. Gill
    • Michael B. Mascia
    • Gabby N. Ahmadia
    • Louise Glew
    • Sarah E. Lester
    • Megan Barnes
    • Ian Craigie
    • Emily S. Darling
    • Christopher M. Free
    • Jonas Geldmann
    • Susie Holst
    • Olaf P. Jensen
    • Alan T. White
    • Xavier Basurto
    • Lauren Coad
    • Ruth D. Gates
    • Greg Guannel
    • Peter J. Mumby
    • Hannah Thomas
    • Sarah Whitmee
    • Stephen Woodley
    • Helen E. Fox

    Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.

    See also
  • Neural ensemble dynamics underlying a long-term associative memory

    • Benjamin F. Grewe
    • Jan Gründemann
    • Lacey J. Kitch
    • Jerome A. Lecoq
    • Jones G. Parker
    • Jesse D. Marshall
    • Margaret C. Larkin
    • Pablo E. Jercog
    • Francois Grenier
    • Jin Zhong Li
    • Andreas Lüthi
    • Mark J. Schnitzer

    Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.

  • A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

    • Felipe de Sousa e Melo
    • Antonina V. Kurtova
    • Jonathan M. Harnoss
    • Noelyn Kljavin
    • Joerg D. Hoeck
    • Jeffrey Hung
    • Jeffrey Eastham Anderson
    • Elaine E. Storm
    • Zora Modrusan
    • Hartmut Koeppen
    • Gerrit J. P. Dijkgraaf
    • Robert Piskol
    • Frederic J. de Sauvage

    Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.

    See also
  • LACTB is a tumour suppressor that modulates lipid metabolism and cell state

    • Zuzana Keckesova
    • Joana Liu Donaher
    • Jasmine De Cock
    • Elizaveta Freinkman
    • Susanne Lingrell
    • Daniel A. Bachovchin
    • Brian Bierie
    • Verena Tischler
    • Aurelia Noske
    • Marian C. Okondo
    • Ferenc Reinhardt
    • Prathapan Thiru
    • Todd R. Golub
    • Jean E. Vance
    • Robert A. Weinberg

    LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.


  • Ultra-selective high-flux membranes from directly synthesized zeolite nanosheets

    • Mi Young Jeon
    • Donghun Kim
    • Prashant Kumar
    • Pyung Soo Lee
    • Neel Rangnekar
    • Peng Bai
    • Meera Shete
    • Bahman Elyassi
    • Han Seung Lee
    • Katabathini Narasimharao
    • Sulaiman Nasir Basahel
    • Shaeel Al-Thabaiti
    • Wenqian Xu
    • Hong Je Cho
    • Evgenii O. Fetisov
    • Raghuram Thyagarajan
    • Robert F. DeJaco
    • Wei Fan
    • K. Andre Mkhoyan
    • J. Ilja Siepmann
    • Michael Tsapatsis

    A direct synthesis of high-aspect-ratio microporous zeolite nanosheets and the use of such nanosheets in separation membranes are described.

  • A low-spin Fe(iii) complex with 100-ps ligand-to-metal charge transfer photoluminescence

    • Pavel Chábera
    • Yizhu Liu
    • Om Prakash
    • Erling Thyrhaug
    • Amal El Nahhas
    • Alireza Honarfar
    • Sofia Essén
    • Lisa A. Fredin
    • Tobias C. B. Harlang
    • Kasper S. Kjær
    • Karsten Handrup
    • Fredric Ericson
    • Hideyuki Tatsuno
    • Kelsey Morgan
    • Joachim Schnadt
    • Lennart Häggström
    • Tore Ericsson
    • Adam Sobkowiak
    • Sven Lidin
    • Ping Huang
    • Stenbjörn Styring
    • Jens Uhlig
    • Jesper Bendix
    • Reiner Lomoth
    • Villy Sundström
    • Petter Persson
    • Kenneth Wärnmark

    An iron complex is described that exhibits photoluminescence at room temperature, opening the way to the use of iron-based materials as low-cost, non-toxic light emitters and photosensitizers.

    See also
  • Transboundary health impacts of transported global air pollution and international trade

    • Qiang Zhang
    • Xujia Jiang
    • Dan Tong
    • Steven J. Davis
    • Hongyan Zhao
    • Guannan Geng
    • Tong Feng
    • Bo Zheng
    • Zifeng Lu
    • David G. Streets
    • Ruijing Ni
    • Michael Brauer
    • Aaron van Donkelaar
    • Randall V. Martin
    • Hong Huo
    • Zhu Liu
    • Da Pan
    • Haidong Kan
    • Yingying Yan
    • Jintai Lin
    • Kebin He
    • Dabo Guan

    The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.

    See also
  • Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

    • Young Seok Ju
    • Inigo Martincorena
    • Moritz Gerstung
    • Mia Petljak
    • Ludmil B. Alexandrov
    • Raheleh Rahbari
    • David C. Wedge
    • Helen R. Davies
    • Manasa Ramakrishna
    • Anthony Fullam
    • Sancha Martin
    • Christopher Alder
    • Nikita Patel
    • Steve Gamble
    • Sarah O’Meara
    • Dilip D. Giri
    • Torril Sauer
    • Sarah E. Pinder
    • Colin A. Purdie
    • Åke Borg
    • Henk Stunnenberg
    • Marc van de Vijver
    • Benita K. T. Tan
    • Carlos Caldas
    • Andrew Tutt
    • Naoto T. Ueno
    • Laura J. van ’t Veer
    • John W. M. Martens
    • Christos Sotiriou
    • Stian Knappskog
    • Paul N. Span
    • Sunil R. Lakhani
    • Jórunn Erla Eyfjörd
    • Anne-Lise Børresen-Dale
    • Andrea Richardson
    • Alastair M. Thompson
    • Alain Viari
    • Matthew E. Hurles
    • Serena Nik-Zainal
    • Peter J. Campbell
    • Michael R. Stratton

    Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.

  • Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

    • Michael S. Khodadoust
    • Niclas Olsson
    • Lisa E. Wagar
    • Ole A. W. Haabeth
    • Binbin Chen
    • Kavya Swaminathan
    • Keith Rawson
    • Chih Long Liu
    • David Steiner
    • Peder Lund
    • Samhita Rao
    • Lichao Zhang
    • Caleb Marceau
    • Henning Stehr
    • Aaron M. Newman
    • Debra K. Czerwinski
    • Victoria E. H. Carlton
    • Martin Moorhead
    • Malek Faham
    • Holbrook E. Kohrt
    • Jan Carette
    • Michael R. Green
    • Mark M. Davis
    • Ronald Levy
    • Joshua E. Elias
    • Ash A. Alizadeh

    Evidence for the abundant presentation of class II neoantigens by a human B-cell lymphoma.

  • Effective combinatorial immunotherapy for castration-resistant prostate cancer

    • Xin Lu
    • James W. Horner
    • Erin Paul
    • Xiaoying Shang
    • Patricia Troncoso
    • Pingna Deng
    • Shan Jiang
    • Qing Chang
    • Denise J. Spring
    • Padmanee Sharma
    • John A. Zebala
    • Dean Y. Maeda
    • Y. Alan Wang
    • Ronald A. DePinho

    A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.

  • The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

    • Andrew A. Wylie
    • Joseph Schoepfer
    • Wolfgang Jahnke
    • Sandra W. Cowan-Jacob
    • Alice Loo
    • Pascal Furet
    • Andreas L. Marzinzik
    • Xavier Pelle
    • Jerry Donovan
    • Wenjing Zhu
    • Silvia Buonamici
    • A. Quamrul Hassan
    • Franco Lombardo
    • Varsha Iyer
    • Michael Palmer
    • Giuliano Berellini
    • Stephanie Dodd
    • Sanjeev Thohan
    • Hans Bitter
    • Susan Branford
    • David M. Ross
    • Timothy P. Hughes
    • Lilli Petruzzelli
    • K. Gary Vanasse
    • Markus Warmuth
    • Francesco Hofmann
    • Nicholas J. Keen
    • William R. Sellers

    The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.

  • Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

    • Brandy Verhalen
    • Reza Dastvan
    • Sundarapandian Thangapandian
    • Yelena Peskova
    • Hanane A. Koteiche
    • Robert K. Nakamoto
    • Emad Tajkhorshid
    • Hassane S. Mchaourab

    Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.