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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 555 Number 7698 pp559-688

29 March 2018

About the cover

The dark caves that blind Mexican cavefish (Astyanax mexicanus) call home is an extreme environment in which food is scarce. As a result, the fish lead a famine-and-feast way life that has led them to adapt in a remarkable way, as Nicolas Rohner, Cliff Tabin and their colleagues reveal in this week's issue. The cavefish carry a mutation in the insulin receptor that would cause severe type 2 diabetes in humans. The resulting high blood-glucose levels seem to cause no ill effects in the fish, which are healthy and have a normal lifespan. The authors speculate that the fish have evolved compensatory mechanisms in their regulation of glucose that allow them to survive in their challenging environment. Cover image: Paulo Oliveira/Alamy

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Brief Communications Arising



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    • Patrick J. Short
    • Jeremy F. McRae
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    • Alejandro Sifrim
    • Hyejung Won
    • Daniel H. Geschwind
    • Caroline F. Wright
    • Helen V. Firth
    • David R. FitzPatrick
    • Jeffrey C. Barrett
    • Matthew E. Hurles

    Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain.

  • Encoding of danger by parabrachial CGRP neurons

    • Carlos A. Campos
    • Anna J. Bowen
    • Carolyn W. Roman
    • Richard D. Palmiter

    Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.

  • Extensive impact of non-antibiotic drugs on human gut bacteria

    • Lisa Maier
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    • Michael Kuhn
    • Georg Zeller
    • Anja Telzerow
    • Exene Erin Anderson
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    • Keith Conrad Fernandez
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    • Peer Bork
    • Athanasios Typas

    A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro.


  • A galaxy lacking dark matter

    • Pieter van Dokkum
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    • Yotam Cohen
    • Allison Merritt
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    • Jean Brodie
    • Charlie Conroy
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    • Lamiya Mowla
    • Ewan O’Sullivan
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    Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.

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    • T. F. Watson
    • S. G. J. Philips
    • E. Kawakami
    • D. R. Ward
    • P. Scarlino
    • M. Veldhorst
    • D. E. Savage
    • M. G. Lagally
    • Mark Friesen
    • S. N. Coppersmith
    • M. A. Eriksson
    • L. M. K. Vandersypen

    A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.

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    • Linda Ye
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  • Insulin resistance in cavefish as an adaptation to a nutrient-limited environment

    • Misty R. Riddle
    • Ariel C. Aspiras
    • Karin Gaudenz
    • Robert Peuß
    • Jenny Y. Sung
    • Brian Martineau
    • Megan Peavey
    • Andrew C. Box
    • Julius A. Tabin
    • Suzanne McGaugh
    • Richard Borowsky
    • Clifford J. Tabin
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    Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.

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    Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.

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    • J. Christoph
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    Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.

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