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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 542 Number 7640 pp138-266

9 February 2017

About the cover

The cover shows a reconstruction of Saccorhytus coronarius, a newly identified deuterostome dating back to the earliest Cambrian period in China. Deuterostomes constitute an array of organisms as varied as vertebrates, starfish, acorn worms and tunicates. But this range of forms, and a lack of extant morphological intermediates, makes it difficult to understand what early deuterostomes were like. The tiny fossils described by Simon Conway Morris and his Chinese colleagues reveal creatures with bag-like bodies and no anus. The primitive features seen in the remains have led the researchers to interpret them as the most basal known deuterostomes, suggesting that their earliest history lies among the meiofauna. Cover image: Jian Han/Dinghua Yan.

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  • Sustainability: Growing pains

    Richard B. Norgaard is troubled by the incrementalism of Jeffrey Sachs's modest new plan for the US economy.

    • Review of Building the New American Economy: Smart, Fair, and Sustainable
      Jeffrey D. Sachs
  • Medical research: The vaccine chronicles

    Ewen Callaway extols a study on the creation of a cell line key to combating rubella.

    • Review of The Vaccine Race: Science, Politics, and the Human Costs of Defeating Disease
      Meredith Wadman
  • Physics: A cosmos in the lab

    Andreas Albrecht ponders a study of the physicists who grapple with the origins of the Universe.

    • Review of A Big Bang in a Little Room: The Quest to Create New Universes
      Zeeya Merali

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  • Rare and low-frequency coding variants alter human adult height

    • Eirini Marouli
    • Mariaelisa Graff
    • Carolina Medina-Gomez
    • Ken Sin Lo
    • Andrew R. Wood
    • Troels R. Kjaer
    • Rebecca S. Fine
    • Yingchang Lu
    • Claudia Schurmann
    • Heather M. Highland
    • Sina Rüeger
    • Gudmar Thorleifsson
    • Anne E. Justice
    • David Lamparter
    • Kathleen E. Stirrups
    • Valérie Turcot
    • Kristin L. Young
    • Thomas W. Winkler
    • Tõnu Esko
    • Tugce Karaderi
    • Adam E. Locke
    • Nicholas G. D. Masca
    • Maggie C. Y. Ng
    • Poorva Mudgal
    • Manuel A. Rivas
    • Sailaja Vedantam
    • Anubha Mahajan
    • Xiuqing Guo
    • Goncalo Abecasis
    • Katja K. Aben
    • Linda S. Adair
    • Dewan S. Alam
    • Eva Albrecht
    • Kristine H. Allin
    • Matthew Allison
    • Philippe Amouyel
    • Emil V. Appel
    • Dominique Arveiler
    • Folkert W. Asselbergs
    • Paul L. Auer
    • Beverley Balkau
    • Bernhard Banas
    • Lia E. Bang
    • Marianne Benn
    • Sven Bergmann
    • Lawrence F. Bielak
    • Matthias Blüher
    • Heiner Boeing
    • Eric Boerwinkle
    • Carsten A. Böger
    • Lori L. Bonnycastle
    • Jette Bork-Jensen
    • Michiel L. Bots
    • Erwin P. Bottinger
    • Donald W. Bowden
    • Ivan Brandslund
    • Gerome Breen
    • Murray H. Brilliant
    • Linda Broer
    • Amber A. Burt
    • Adam S. Butterworth
    • David J. Carey
    • Mark J. Caulfield
    • John C. Chambers
    • Daniel I. Chasman
    • Yii-Der Ida Chen
    • Rajiv Chowdhury
    • Cramer Christensen
    • Audrey Y. Chu
    • Massimiliano Cocca
    • Francis S. Collins
    • James P. Cook
    • Janie Corley
    • Jordi Corominas Galbany
    • Amanda J. Cox
    • Gabriel Cuellar-Partida
    • John Danesh
    • Gail Davies
    • Paul I. W. de Bakker
    • Gert J. de Borst
    • Simon de Denus
    • Mark C. H. de Groot
    • Renée de Mutsert
    • Ian J. Deary
    • George Dedoussis
    • Ellen W. Demerath
    • Anneke I. den Hollander
    • Joe G. Dennis
    • Emanuele Di Angelantonio
    • Fotios Drenos
    • Mengmeng Du
    • Alison M. Dunning
    • Douglas F. Easton
    • Tapani Ebeling
    • Todd L. Edwards
    • Patrick T. Ellinor
    • Paul Elliott
    • Evangelos Evangelou
    • Aliki-Eleni Farmaki
    • Jessica D. Faul
    • Mary F. Feitosa
    • Shuang Feng
    • Ele Ferrannini
    • Marco M. Ferrario
    • Jean Ferrieres
    • Jose C. Florez
    • Ian Ford
    • Myriam Fornage
    • Paul W. Franks
    • Ruth Frikke-Schmidt
    • Tessel E. Galesloot
    • Wei Gan
    • Ilaria Gandin
    • Paolo Gasparini
    • Vilmantas Giedraitis
    • Ayush Giri
    • Giorgia Girotto
    • Scott D. Gordon
    • Penny Gordon-Larsen
    • Mathias Gorski
    • Niels Grarup
    • Megan L. Grove
    • Vilmundur Gudnason
    • Stefan Gustafsson
    • Torben Hansen
    • Kathleen Mullan Harris
    • Tamara B. Harris
    • Andrew T. Hattersley
    • Caroline Hayward
    • Liang He
    • Iris M. Heid
    • Kauko Heikkilä
    • Øyvind Helgeland
    • Jussi Hernesniemi
    • Alex W. Hewitt
    • Lynne J. Hocking
    • Mette Hollensted
    • Oddgeir L. Holmen
    • G. Kees Hovingh
    • Joanna M. M. Howson
    • Carel B. Hoyng
    • Paul L. Huang
    • Kristian Hveem
    • M. Arfan Ikram
    • Erik Ingelsson
    • Anne U. Jackson
    • Jan-Håkan Jansson
    • Gail P. Jarvik
    • Gorm B. Jensen
    • Min A. Jhun
    • Yucheng Jia
    • Xuejuan Jiang
    • Stefan Johansson
    • Marit E. Jørgensen
    • Torben Jørgensen
    • Pekka Jousilahti
    • J. Wouter Jukema
    • Bratati Kahali
    • René S. Kahn
    • Mika Kähönen
    • Pia R. Kamstrup
    • Stavroula Kanoni
    • Jaakko Kaprio
    • Maria Karaleftheri
    • Sharon L. R. Kardia
    • Fredrik Karpe
    • Frank Kee
    • Renske Keeman
    • Lambertus A. Kiemeney
    • Hidetoshi Kitajima
    • Kirsten B. Kluivers
    • Thomas Kocher
    • Pirjo Komulainen
    • Jukka Kontto
    • Jaspal S. Kooner
    • Charles Kooperberg
    • Peter Kovacs
    • Jennifer Kriebel
    • Helena Kuivaniemi
    • Sébastien Küry
    • Johanna Kuusisto
    • Martina La Bianca
    • Markku Laakso
    • Timo A. Lakka
    • Ethan M. Lange
    • Leslie A. Lange
    • Carl D. Langefeld
    • Claudia Langenberg
    • Eric B. Larson
    • I-Te Lee
    • Terho Lehtimäki
    • Cora E. Lewis
    • Huaixing Li
    • Jin Li
    • Ruifang Li-Gao
    • Honghuang Lin
    • Li-An Lin
    • Xu Lin
    • Lars Lind
    • Jaana Lindström
    • Allan Linneberg
    • Yeheng Liu
    • Yongmei Liu
    • Artitaya Lophatananon
    • Jian'an Luan
    • Steven A. Lubitz
    • Leo-Pekka Lyytikäinen
    • David A. Mackey
    • Pamela A. F. Madden
    • Alisa K. Manning
    • Satu Männistö
    • Gaëlle Marenne
    • Jonathan Marten
    • Nicholas G. Martin
    • Angela L. Mazul
    • Karina Meidtner
    • Andres Metspalu
    • Paul Mitchell
    • Karen L. Mohlke
    • Dennis O. Mook-Kanamori
    • Anna Morgan
    • Andrew D. Morris
    • Andrew P. Morris
    • Martina Müller-Nurasyid
    • Patricia B. Munroe
    • Mike A. Nalls
    • Matthias Nauck
    • Christopher P. Nelson
    • Matt Neville
    • Sune F. Nielsen
    • Kjell Nikus
    • Pål R. Njølstad
    • Børge G. Nordestgaard
    • Ioanna Ntalla
    • Jeffrey R. O'Connel
    • Heikki Oksa
    • Loes M. Olde Loohuis
    • Roel A. Ophoff
    • Katharine R. Owen
    • Chris J. Packard
    • Sandosh Padmanabhan
    • Colin N. A. Palmer
    • Gerard Pasterkamp
    • Aniruddh P. Patel
    • Alison Pattie
    • Oluf Pedersen
    • Peggy L. Peissig
    • Gina M. Peloso
    • Craig E. Pennell
    • Markus Perola
    • James A. Perry
    • John R. B. Perry
    • Thomas N. Person
    • Ailith Pirie
    • Ozren Polasek
    • Danielle Posthuma
    • Olli T. Raitakari
    • Asif Rasheed
    • Rainer Rauramaa
    • Dermot F. Reilly
    • Alex P. Reiner
    • Frida Renström
    • Paul M. Ridker
    • John D. Rioux
    • Neil Robertson
    • Antonietta Robino
    • Olov Rolandsson
    • Igor Rudan
    • Katherine S. Ruth
    • Danish Saleheen
    • Veikko Salomaa
    • Nilesh J. Samani
    • Kevin Sandow
    • Yadav Sapkota
    • Naveed Sattar
    • Marjanka K. Schmidt
    • Pamela J. Schreiner
    • Matthias B. Schulze
    • Robert A. Scott
    • Marcelo P. Segura-Lepe
    • Svati Shah
    • Xueling Sim
    • Suthesh Sivapalaratnam
    • Kerrin S. Small
    • Albert Vernon Smith
    • Jennifer A. Smith
    • Lorraine Southam
    • Timothy D. Spector
    • Elizabeth K. Speliotes
    • John M. Starr
    • Valgerdur Steinthorsdottir
    • Heather M. Stringham
    • Michael Stumvoll
    • Praveen Surendran
    • Leen M. ‘t Hart
    • Katherine E. Tansey
    • Jean-Claude Tardif
    • Kent D. Taylor
    • Alexander Teumer
    • Deborah J. Thompson
    • Unnur Thorsteinsdottir
    • Betina H. Thuesen
    • Anke Tönjes
    • Gerard Tromp
    • Stella Trompet
    • Emmanouil Tsafantakis
    • Jaakko Tuomilehto
    • Anne Tybjaerg-Hansen
    • Jonathan P. Tyrer
    • Rudolf Uher
    • André G. Uitterlinden
    • Sheila Ulivi
    • Sander W. van der Laan
    • Andries R. Van Der Leij
    • Cornelia M. van Duijn
    • Natasja M. van Schoor
    • Jessica van Setten
    • Anette Varbo
    • Tibor V. Varga
    • Rohit Varma
    • Digna R. Velez Edwards
    • Sita H. Vermeulen
    • Henrik Vestergaard
    • Veronique Vitart
    • Thomas F. Vogt
    • Diego Vozzi
    • Mark Walker
    • Feijie Wang
    • Carol A. Wang
    • Shuai Wang
    • Yiqin Wang
    • Nicholas J. Wareham
    • Helen R. Warren
    • Jennifer Wessel
    • Sara M. Willems
    • James G. Wilson
    • Daniel R. Witte
    • Michael O. Woods
    • Ying Wu
    • Hanieh Yaghootkar
    • Jie Yao
    • Pang Yao
    • Laura M. Yerges-Armstrong
    • Robin Young
    • Eleftheria Zeggini
    • Xiaowei Zhan
    • Weihua Zhang
    • Jing Hua Zhao
    • Wei Zhao
    • Wei Zhao
    • He Zheng
    • Wei Zhou
    • The EPIC-InterAct Consortium
    • CHD Exome+ Consortium
    • ExomeBP Consortium
    • T2D-Genes Consortium
    • GoT2D Genes Consortium
    • Global Lipids Genetics Consortium
    • ReproGen Consortium
    • MAGIC Investigators
    • Jerome I Rotter
    • Michael Boehnke
    • Sekar Kathiresan
    • Mark I. McCarthy
    • Cristen J. Willer
    • Kari Stefansson
    • Ingrid B. Borecki
    • Dajiang J. Liu
    • Kari E. North
    • Nancy L. Heard-Costa
    • Tune H. Pers
    • Cecilia M. Lindgren
    • Claus Oxvig
    • Zoltán Kutalik
    • Fernando Rivadeneira
    • Ruth J. F. Loos
    • Timothy M. Frayling
    • Joel N. Hirschhorn
    • Panos Deloukas
    • Guillaume Lettre

    Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

  • Interspecies organogenesis generates autologous functional islets

    • Tomoyuki Yamaguchi
    • Hideyuki Sato
    • Megumi Kato-Itoh
    • Teppei Goto
    • Hiromasa Hara
    • Makoto Sanbo
    • Naoaki Mizuno
    • Toshihiro Kobayashi
    • Ayaka Yanagida
    • Ayumi Umino
    • Yasunori Ota
    • Sanae Hamanaka
    • Hideki Masaki
    • Sheikh Tamir Rashid
    • Masumi Hirabayashi
    • Hiromitsu Nakauchi

    The authors inject mouse pluripotent stem cells into pancreatogenesis-disabled rat blastocysts and thereby generate rats with mouse pancreata from which the islets, when transplanted into mice, can provide a long-term cure for symptoms of diabetes, without continuous immunosuppression.

    See also
  • An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

    • Ryan J. Golden
    • Beibei Chen
    • Tuo Li
    • Juliane Braun
    • Hema Manjunath
    • Xiang Chen
    • Jiaxi Wu
    • Vanessa Schmid
    • Tsung-Cheng Chang
    • Florian Kopp
    • Andres Ramirez-Martinez
    • Vincent S. Tagliabracci
    • Zhijian J. Chen
    • Yang Xie
    • Joshua T. Mendell

    The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression.

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