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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 542 Number 7639 pp5-132

2 February 2017

About the cover

The cover shows how the detection of skin cancer could be simplified and extended by using artificial intelligence. Andre Esteva et al. used 129,450 clinical images of skin disease to train a deep convolutional neural network to classify skin lesions. The result is an algorithm that can classify lesions from photographic images similar to those taken with a mobile phone. The accuracy of the system in detecting malignant melanomas and carcinomas matched that of trained dermatologists. The authors suggest that the technique could be used outside the clinic as a visual screen for cancer. Cover: Dejapong I. Suwaratana & Uri Tzarnotzky.

This Week



World View


Seven Days


News in Focus




Books and Arts

  • Physics: The wave catchers

    Davide Castelvecchi applauds an inside story on the discovery of gravitational waves.

    • Review of Gravity's Kiss: The Detection of Gravitational Waves
      Harry Collins
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.

  • Cognitive science: Dennett rides again

    Dan Jones relishes the philosopher's latest exploration of minds and memes.

    • Review of From Bacteria to Bach and Back: The Evolution of Minds
      Daniel C. Dennett





  • Look before you leap

    If your job is at risk, don't wait until the last minute before planning a safe landing.

    • Peter Fiske



naturejobs job listings and advertising features




  • The Internet of Things comes to the lab

    The system of connecting machines and sensors is finally making its way into the laboratory, giving researchers peace of mind and restoring their work–life balance.

    • Jeffrey M. Perkel



  • IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

    • Changchun Chen
    • Eisuke Itakura
    • Geoffrey M. Nelson
    • Ming Sheng
    • Patrick Laurent
    • Lorenz A. Fenk
    • Rebecca A. Butcher
    • Ramanujan S. Hegde
    • Mario de Bono

    Interleukin-17 functions as a neuromodulator in the roundworm Caenorhabditis elegans, acting directly on RMG hub interneurons to alter their response properties and contribution to behaviour.

  • The role of fatty acid β-oxidation in lymphangiogenesis

    • Brian W. Wong
    • Xingwu Wang
    • Annalisa Zecchin
    • Bernard Thienpont
    • Ivo Cornelissen
    • Joanna Kalucka
    • Melissa García-Caballero
    • Rindert Missiaen
    • Hongling Huang
    • Ulrike Brüning
    • Silvia Blacher
    • Stefan Vinckier
    • Jermaine Goveia
    • Marlen Knobloch
    • Hui Zhao
    • Cathrin Dierkes
    • Chenyan Shi
    • René Hägerling
    • Veronica Moral-Dardé
    • Sabine Wyns
    • Martin Lippens
    • Sebastian Jessberger
    • Sarah-Maria Fendt
    • Aernout Luttun
    • Agnès Noel
    • Friedemann Kiefer
    • Bart Ghesquière
    • Lieve Moons
    • Luc Schoonjans
    • Mieke Dewerchin
    • Guy Eelen
    • Diether Lambrechts
    • Peter Carmeliet

    The lymphangiogenic factor PROX1 transcriptionally upregulates CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, and this co-regulates lymphatic endothelial cell differentiation by epigenetic control of lymphatic gene expression, demonstrating a role for metabolism in developmental biology.

  • Structure of a eukaryotic cyclic-nucleotide-gated channel

    • Minghui Li
    • Xiaoyuan Zhou
    • Shu Wang
    • Ioannis Michailidis
    • Ye Gong
    • Deyuan Su
    • Huan Li
    • Xueming Li
    • Jian Yang

    The first high-resolution (3.5 Å) structure of a full-length cyclic-nucleotide-gated channel, revealing an unconventional, voltage-insensitive voltage-sensor domain and a unique coupling mechanism between cyclic-nucleotide-binding and pore-opening.


  • Spin–orbit-coupled fermions in an optical lattice clock

    • S. Kolkowitz
    • S. L. Bromley
    • T. Bothwell
    • M. L. Wall
    • G. E. Marti
    • A. P. Koller
    • X. Zhang
    • A. M. Rey
    • J. Ye

    Spin–orbit coupling is implemented in an optical lattice clock using a narrow optical transition in fermionic 87Sr atoms, thus mitigating the heating problems of previous experiments with alkali atoms and offering new prospects for future investigations.

  • Deciphering chemical order/disorder and material properties at the single-atom level

    • Yongsoo Yang
    • Chien-Chun Chen
    • M. C. Scott
    • Colin Ophus
    • Rui Xu
    • Alan Pryor
    • Li Wu
    • Fan Sun
    • Wolfgang Theis
    • Jihan Zhou
    • Markus Eisenbach
    • Paul R. C. Kent
    • Renat F. Sabirianov
    • Hao Zeng
    • Peter Ercius
    • Jianwei Miao

    The three-dimensional coordinates of more than 23,000 atoms in an iron-platinum nanoparticle are determined with 22 picometre precision to correlate chemical order/disorder and crystal defects with magnetic properties.

    See also
  • Elevation alters ecosystem properties across temperate treelines globally

    • Jordan R. Mayor
    • Nathan J. Sanders
    • Aimée T. Classen
    • Richard D. Bardgett
    • Jean-Christophe Clément
    • Alex Fajardo
    • Sandra Lavorel
    • Maja K. Sundqvist
    • Michael Bahn
    • Chelsea Chisholm
    • Ellen Cieraad
    • Ze’ev Gedalof
    • Karl Grigulis
    • Gaku Kudo
    • Daniel L. Oberski
    • David A. Wardle

    Examination of the ecosystem properties of treeline ecotones in seven temperate regions of the world shows that the reduction in temperature with increasing elevation does not affect tree leaf nutrient concentrations, but does reduce ground-layer community-weighted plant nitrogen levels, leading to a strong stoichiometric convergence of ground-layer plant community nitrogen to phosphorus ratios across all regions.

  • Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolutionOpen

    • Gavin G. Rutledge
    • Ulrike Böhme
    • Mandy Sanders
    • Adam J. Reid
    • James A. Cotton
    • Oumou Maiga-Ascofare
    • Abdoulaye A. Djimdé
    • Tobias O. Apinjoh
    • Lucas Amenga-Etego
    • Magnus Manske
    • John W. Barnwell
    • François Renaud
    • Benjamin Ollomo
    • Franck Prugnolle
    • Nicholas M. Anstey
    • Sarah Auburn
    • Ric N. Price
    • James S. McCarthy
    • Dominic P. Kwiatkowski
    • Chris I. Newbold
    • Matthew Berriman
    • Thomas D. Otto

    The genome sequences of the neglected human-infective malaria species Plasmodium malariae and P. ovale provide new insights into their biology that are pertinent to understanding their epidemiology and to the broader agenda of malaria elimination.

  • MATRILINEAL, a sperm-specific phospholipase, triggers maize haploid induction

    • Timothy Kelliher
    • Dakota Starr
    • Lee Richbourg
    • Satya Chintamanani
    • Brent Delzer
    • Michael L. Nuccio
    • Julie Green
    • Zhongying Chen
    • Jamie McCuiston
    • Wenling Wang
    • Tara Liebler
    • Paul Bullock
    • Barry Martin

    A frame-shift mutation in MATRILINEAL, a pollen-specific phospholipase, triggers haploid induction in maize, which may be useful in developing improved haploid induction systems for crop breeding.

  • Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

    • Deepak A. Rao
    • Michael F. Gurish
    • Jennifer L. Marshall
    • Kamil Slowikowski
    • Chamith Y. Fonseka
    • Yanyan Liu
    • Laura T. Donlin
    • Lauren A. Henderson
    • Kevin Wei
    • Fumitaka Mizoguchi
    • Nikola C. Teslovich
    • Michael E. Weinblatt
    • Elena M. Massarotti
    • Jonathan S. Coblyn
    • Simon M. Helfgott
    • Yvonne C. Lee
    • Derrick J. Todd
    • Vivian P. Bykerk
    • Susan M. Goodman
    • Alessandra B. Pernis
    • Lionel B. Ivashkiv
    • Elizabeth W. Karlson
    • Peter A. Nigrovic
    • Andrew Filer
    • Christopher D. Buckley
    • James A. Lederer
    • Soumya Raychaudhuri
    • Michael B. Brenner

    The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.

  • Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

    • Prasenjit Dey
    • Joelle Baddour
    • Florian Muller
    • Chia Chin Wu
    • Huamin Wang
    • Wen-Ting Liao
    • Zangdao Lan
    • Alina Chen
    • Tony Gutschner
    • Yaan Kang
    • Jason Fleming
    • Nikunj Satani
    • Di Zhao
    • Abhinav Achreja
    • Lifeng Yang
    • Jiyoon Lee
    • Edward Chang
    • Giannicola Genovese
    • Andrea Viale
    • Haoqiang Ying
    • Giulio Draetta
    • Anirban Maitra
    • Y. Alan Wang
    • Deepak Nagrath
    • Ronald A. DePinho

    Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.

    See also


  • Corrigendum: Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

    • Ana Latorre-Pellicer
    • Raquel Moreno-Loshuertos
    • Ana Victoria Lechuga-Vieco
    • Fátima Sánchez-Cabo
    • Carlos Torroja
    • Rebeca Acín-Pérez
    • Enrique Calvo
    • Esther Aix
    • Andrés González-Guerra
    • Angela Logan
    • María Luisa Bernad-Miana
    • Eduardo Romanos
    • Raquel Cruz
    • Sara Cogliati
    • Beatriz Sobrino
    • Ángel Carracedo
    • Acisclo Pérez-Martos
    • Patricio Fernández-Silva
    • Jesús Ruíz-Cabello
    • Michael P. Murphy
    • Ignacio Flores
    • Jesús Vázquez
    • José Antonio Enríquez
  • Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

    • Megan M. Kaneda
    • Karen S. Messer
    • Natacha Ralainirina
    • Hongying Li
    • Christopher J. Leem
    • Sara Gorjestani
    • Gyunghwi Woo
    • Abraham V. Nguyen
    • Camila C. Figueiredo
    • Philippe Foubert
    • Michael C. Schmid
    • Melissa Pink
    • David G. Winkler
    • Matthew Rausch
    • Vito J. Palombella
    • Jeffery Kutok
    • Karen McGovern
    • Kelly A. Frazer
    • Xuefeng Wu
    • Michael Karin
    • Roman Sasik
    • Ezra E. W. Cohen
    • Judith A. Varner


  • Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

    • Faiyaz Notta
    • Michelle Chan-Seng-Yue
    • Mathieu Lemire
    • Yilong Li
    • Gavin W. Wilson
    • Ashton A. Connor
    • Robert E. Denroche
    • Sheng-Ben Liang
    • Andrew M. K. Brown
    • Jaeseung C. Kim
    • Tao Wang
    • Jared T. Simpson
    • Timothy Beck
    • Ayelet Borgida
    • Nicholas Buchner
    • Dianne Chadwick
    • Sara Hafezi-Bakhtiari
    • John E. Dick
    • Lawrence Heisler
    • Michael A. Hollingsworth
    • Emin Ibrahimov
    • Gun Ho Jang
    • Jeremy Johns
    • Lars G. T. Jorgensen
    • Calvin Law
    • Olga Ludkovski
    • Ilinca Lungu
    • Karen Ng
    • Danielle Pasternack
    • Gloria M. Petersen
    • Liran I. Shlush
    • Lee Timms
    • Ming-Sound Tsao
    • Julie M. Wilson
    • Christina K. Yung
    • George Zogopoulos
    • John M. S. Bartlett
    • Ludmil B. Alexandrov
    • Francisco X. Real
    • Sean P. Cleary
    • Michael H. Roehrl
    • John D. McPherson
    • Lincoln D. Stein
    • Thomas J. Hudson
    • Peter J. Campbell
    • Steven Gallinger