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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 540 Number 7634 pp484-614

22 December 2016

About the cover

Once again, we end the year by selecting Nature’s 10’, ten scientists whose work this year has had an important impact in their respective fields. They are Gabriela Gonzalez, Demis Hassabis, Terry Hughes, Guus Velders, Celina M. Turchi, Alexandra Elbakyan, John Zhang, Kevin Esvelt, Guillem Anglada-Escudé and Elena Long. Cover: ‘Gravity waves’ JVG/Folio art

News in Focus




  • Take the long view

    At the end of a difficult year for evidence, Ian L. Boyd, a chief scientific adviser to the UK government, draws lessons for making research more relevant.

Books and Arts





naturejobs job listings and advertising features



Outlook: Inflammatory bowel disease



  • Redefining the invertebrate RNA virosphere

    • Mang Shi
    • Xian-Dan Lin
    • Jun-Hua Tian
    • Liang-Jun Chen
    • Xiao Chen
    • Ci-Xiu Li
    • Xin-Cheng Qin
    • Jun Li
    • Jian-Ping Cao
    • John-Sebastian Eden
    • Jan Buchmann
    • Wen Wang
    • Jianguo Xu
    • Edward C. Holmes
    • Yong-Zhen Zhang

    Profiling the total RNA of 220 invertebrate species leads to the discovery of almost 1,500 new species of RNA virus, revealing that the RNA virosphere is much more diverse than was previously thought.

  • Persistent microbiome alterations modulate the rate of post-dieting weight regain

    • Christoph A. Thaiss
    • Shlomik Itav
    • Daphna Rothschild
    • Mariska T. Meijer
    • Maayan Levy
    • Claudia Moresi
    • Lenka Dohnalová
    • Sofia Braverman
    • Shachar Rozin
    • Sergey Malitsky
    • Mally Dori-Bachash
    • Yael Kuperman
    • Inbal Biton
    • Arieh Gertler
    • Alon Harmelin
    • Hagit Shapiro
    • Zamir Halpern
    • Asaph Aharoni
    • Eran Segal
    • Eran Elinav

    The identification of an intestinal microbiome signature that persists after successful dieting in obese mice and contributes to faster weight regain upon re-exposure to an obesity-promoting diet, and that transmits the altered weight regain phenotype to non-dieting mice.

  • Early dissemination seeds metastasis in breast cancer

    • Hedayatollah Hosseini
    • Milan M. S. Obradović
    • Martin Hoffmann
    • Kathryn L. Harper
    • Maria Soledad Sosa
    • Melanie Werner-Klein
    • Lahiri Kanth Nanduri
    • Christian Werno
    • Carolin Ehrl
    • Matthias Maneck
    • Nina Patwary
    • Gundula Haunschild
    • Miodrag Gužvić
    • Christian Reimelt
    • Michael Grauvogl
    • Norbert Eichner
    • Florian Weber
    • Andreas D. Hartkopf
    • Florin-Andrei Taran
    • Sara Y. Brucker
    • Tanja Fehm
    • Brigitte Rack
    • Stefan Buchholz
    • Rainer Spang
    • Gunter Meister
    • Julio A. Aguirre-Ghiso
    • Christoph A. Klein

    Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

    See also
    See also


  • Evidence for a spinon Fermi surface in a triangular-lattice quantum-spin-liquid candidate

    • Yao Shen
    • Yao-Dong Li
    • Hongliang Wo
    • Yuesheng Li
    • Shoudong Shen
    • Bingying Pan
    • Qisi Wang
    • H. C. Walker
    • P. Steffens
    • M. Boehm
    • Yiqing Hao
    • D. L. Quintero-Castro
    • L. W. Harriger
    • M. D. Frontzek
    • Lijie Hao
    • Siqin Meng
    • Qingming Zhang
    • Gang Chen
    • Jun Zhao

    A spin excitation continuum across a large region of the Brillouin zone that persists at near-zero temperatures provides evidence for a quantum spin liquid state with a spinon Fermi surface in YbMgGaO4.

    See also
  • Water balance creates a threshold in soil pH at the global scale

    • E. W. Slessarev
    • Y. Lin
    • N. L. Bingham
    • J. E. Johnson
    • Y. Dai
    • J. P. Schimel
    • O. A. Chadwick

    There is an abrupt transition from alkaline to acid soil pH when mean annual precipitation exceeds mean annual potential evapotranspiration, demonstrating that climate creates a nonlinear pattern in soil solution chemistry at the global scale.

  • Chemical intervention in plant sugar signalling increases yield and resilience

    • Cara A. Griffiths
    • Ram Sagar
    • Yiqun Geng
    • Lucia F. Primavesi
    • Mitul K. Patel
    • Melissa K. Passarelli
    • Ian S. Gilmore
    • Rory T. Steven
    • Josephine Bunch
    • Matthew J. Paul
    • Benjamin G. Davis

    Treatment with signalling precursors of trehalose-6-phosphate allows light-triggered release of trehalose-6-phosphate in Arabidopsis thaliana and increases the yield and drought resistance of spring wheat (Triticum aestivum).

  • NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

    • Rajendra Karki
    • Si Ming Man
    • R. K. Subbarao Malireddi
    • Sannula Kesavardhana
    • Qifan Zhu
    • Amanda R. Burton
    • Bhesh Raj Sharma
    • Xiaopeng Qi
    • Stephane Pelletier
    • Peter Vogel
    • Philip Rosenstiel
    • Thirumala-Devi Kanneganti

    Mice deficient in the protein NLRC3 are highly prone to colitis and tumour development in the colon as NLRC3 suppresses the activation of mTOR signalling pathways that help drive tumorigenesis.

  • Mechanism of early dissemination and metastasis in Her2+ mammary cancer

    • Kathryn L. Harper
    • Maria Soledad Sosa
    • David Entenberg
    • Hedayatollah Hosseini
    • Julie F. Cheung
    • Rita Nobre
    • Alvaro Avivar-Valderas
    • Chandandaneep Nagi
    • Nomeda Girnius
    • Roger J. Davis
    • Eduardo F. Farias
    • John Condeelis
    • Christoph A. Klein
    • Julio A. Aguirre-Ghiso

    Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

    See also
    See also
  • Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

    • L. J. Worrall
    • C. Hong
    • M. Vuckovic
    • W. Deng
    • J. R. C. Bergeron
    • D. D Majewski
    • R. K. Huang
    • T. Spreter
    • B. B. Finlay
    • Z. Yu
    • N. C. J. Strynadka

    The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the first atomic structure of a member of the secretin family of outer-membrane pores.

  • Structure of RNA polymerase I transcribing ribosomal DNA genes

    • Simon Neyer
    • Michael Kunz
    • Christian Geiss
    • Merle Hantsche
    • Victor-Valentin Hodirnau
    • Anja Seybert
    • Christoph Engel
    • Margot P. Scheffer
    • Patrick Cramer
    • Achilleas S. Frangakis

    Structures of budding yeast RNA polymerase I in a catalytically active conformation are presented and confirmed by visualizing processive transcription along ribosomal DNA genes; they support a general model for transcription elongation in which contracted and expanded polymerase conformations are associated with active and inactive states, respectively.