This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature


Volume 564 Issue 7736, 20 December 2018

Volume 564 Issue 7736, 20 December 2018

One year. Ten stories.

As 2018 draws to a close, we once again select Nature’s 10—ten people who made a difference in research this year. The cover design highlights advances in studies of atom-thick materials with unusual properties. The image represents two graphene sheets offset by a ‘magic’ angle, an arrangement that can behave as a superconductor in certain conditions.

Cover image: JVG

This Week

News in Focus

Comment

Careers

    Features

  • Career Feature |

    If you’re looking to move labs, countries or sectors this year, or seeking general career inspiration, here’s some advice from five researchers who featured in Nature Careers in 2018.

    • Chris Woolston

Futures

  • Futures |

    An unusual invitation.

    • John Gilbey

Research

    News & Views

  • News & Views |

    A study in mice identifies a brain adaptation that underlies the compulsive behaviour associated with drug addiction, and which might explain why some drug users behave compulsively whereas others do not.

    • Patricia Janak
  • News & Views |

    Almost half a century ago, it was predicted that the confinement of quantum fluctuations could induce mechanical rotation — the Casimir torque. This prediction has now been confirmed using liquid crystals.

    • Slobodan Žumer
  • News & Views |

    A modified protocol has enabled baboons that received transplanted pig hearts to survive for more than six months. This improvement on previous efforts brings pig-to-human heart transplants a step closer.

    • Christoph Knosalla
  • News & Views |

    Observations reveal that a particular planetary nebula — the ejected envelope of an old star — is unusually enriched in rare carbon, nitrogen and oxygen isotopes. The finding could help to explain the origins of these isotopes.

    • Amanda Karakas
  • News & Views |

    Some samples of human growth hormone used as therapy until the mid-1980s contain amyloid-β peptide and cause genetically modified mice to develop amyloid-β deposits in the brain.

    • Tien-Phat V. Huynh
    •  & David M. Holtzman
  • Brief Communications Arising

  • Brief Communications Arising |

    • A. Kurnosov
    • , H. Marquardt
    • , D. J. Frost
    • , T. Boffa Ballaran
    •  & L. Ziberna
  • Brief Communications Arising |

    • Judd D. Bowman
    • , Alan E. E. Rogers
    • , Raul A. Monsalve
    • , Thomas J. Mozdzen
    •  & Nivedita Mahesh
  • Articles

  • Article |

    The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.

    • Johan Lindgren
    • , Peter Sjövall
    • , Volker Thiel
    • , Wenxia Zheng
    • , Shosuke Ito
    • , Kazumasa Wakamatsu
    • , Rolf Hauff
    • , Benjamin P. Kear
    • , Anders Engdahl
    • , Carl Alwmark
    • , Mats E. Eriksson
    • , Martin Jarenmark
    • , Sven Sachs
    • , Per E. Ahlberg
    • , Federica Marone
    • , Takeo Kuriyama
    • , Ola Gustafsson
    • , Per Malmberg
    • , Aurélien Thomen
    • , Irene Rodríguez-Meizoso
    • , Per Uvdal
    • , Makoto Ojika
    •  & Mary H. Schweitzer
  • Article |

    In mice, synaptic potentiation of transmission from the orbitofrontal cortex to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.

    • Vincent Pascoli
    • , Agnès Hiver
    • , Ruud Van Zessen
    • , Michaël Loureiro
    • , Ridouane Achargui
    • , Masaya Harada
    • , Jérôme Flakowski
    •  & Christian Lüscher
  • Article |

    Cryo-electron microscopy structures of connexin channels composed of connexin 46 and connexin 50 in an open-state reveal features that govern permselectivity and the location of mutated residues linked to herediatry cataracts.

    • Janette B. Myers
    • , Bassam G. Haddad
    • , Susan E. O’Neill
    • , Dror S. Chorev
    • , Craig C. Yoshioka
    • , Carol V. Robinson
    • , Daniel M. Zuckerman
    •  & Steve L. Reichow
  • Letters

  • Letter |

    The theoretically predicted Casimir torque, which causes charge-neutral, birefringent materials to rotate towards a preferred alignment, is measured.

    • David A. T. Somers
    • , Joseph L. Garrett
    • , Kevin J. Palm
    •  & Jeremy N. Munday
  • Letter |

    An electrically controlled phase transition from topological insulator to conventional insulator in ultrathin films of the topological Dirac semimetal, Na3Bi.

    • James L. Collins
    • , Anton Tadich
    • , Weikang Wu
    • , Lidia C. Gomes
    • , Joao N. B. Rodrigues
    • , Chang Liu
    • , Jack Hellerstedt
    • , Hyejin Ryu
    • , Shujie Tang
    • , Sung-Kwan Mo
    • , Shaffique Adam
    • , Shengyuan A. Yang
    • , Michael S. Fuhrer
    •  & Mark T. Edmonds
  • Letter |

    Vertical motions of Earth’s crust had the greatest effect on regional spatial differences in relative sea-level trends along the eastern coast of the USA during 1900–2017, explaining most of the large-scale spatial variance in regional rates of sea-level rise.

    • Christopher G. Piecuch
    • , Peter Huybers
    • , Carling C. Hay
    • , Andrew C. Kemp
    • , Christopher M. Little
    • , Jerry X. Mitrovica
    • , Rui M. Ponte
    •  & Martin P. Tingley
  • Letter |

    Phylogenetic analyses based on single-cell transcriptomic data from two hemimastigotes, a Spironema species and the newly described Hemimastix kukwesjijk, indicate that Hemimastigophora is a supra-kingdom-level lineage of eukaryotes.

    • Gordon Lax
    • , Yana Eglit
    • , Laura Eme
    • , Erin M. Bertrand
    • , Andrew J. Roger
    •  & Alastair G. B. Simpson
  • Letter |

    Archived vials of cadaveric human growth hormone contain substantial levels of amyloid-β (Aβ) peptides and can seed Aβ plaques in susceptible mice, suggesting that this material could have transmitted Aβ pathology to humans.

    • Silvia A. Purro
    • , Mark A. Farrow
    • , Jacqueline Linehan
    • , Tamsin Nazari
    • , David X. Thomas
    • , Zhicheng Chen
    • , David Mengel
    • , Takashi Saito
    • , Takaomi Saido
    • , Peter Rudge
    • , Sebastian Brandner
    • , Dominic M. Walsh
    •  & John Collinge
  • Letter |

    The identification of a complex haematopoietic system in a colonial tunicate sheds light on the evolution of the mammalian blood system.

    • Benyamin Rosental
    • , Mark Kowarsky
    • , Jun Seita
    • , Daniel M. Corey
    • , Katherine J. Ishizuka
    • , Karla J. Palmeri
    • , Shih-Yu Chen
    • , Rahul Sinha
    • , Jennifer Okamoto
    • , Gary Mantalas
    • , Lucia Manni
    • , Tal Raveh
    • , D. Nathaniel Clarke
    • , Jonathan M. Tsai
    • , Aaron M. Newman
    • , Norma F. Neff
    • , Garry P. Nolan
    • , Stephen R. Quake
    • , Irving L. Weissman
    •  & Ayelet Voskoboynik
  • Letter |

    α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.

    • Matthias Längin
    • , Tanja Mayr
    • , Bruno Reichart
    • , Sebastian Michel
    • , Stefan Buchholz
    • , Sonja Guethoff
    • , Alexey Dashkevich
    • , Andrea Baehr
    • , Stefanie Egerer
    • , Andreas Bauer
    • , Maks Mihalj
    • , Alessandro Panelli
    • , Lara Issl
    • , Jiawei Ying
    • , Ann Kathrin Fresch
    • , Ines Buttgereit
    • , Maren Mokelke
    • , Julia Radan
    • , Fabian Werner
    • , Isabelle Lutzmann
    • , Stig Steen
    • , Trygve Sjöberg
    • , Audrius Paskevicius
    • , Liao Qiuming
    • , Riccardo Sfriso
    • , Robert Rieben
    • , Maik Dahlhoff
    • , Barbara Kessler
    • , Elisabeth Kemter
    • , Katharina Klett
    • , Rabea Hinkel
    • , Christian Kupatt
    • , Almuth Falkenau
    • , Simone Reu
    • , Reinhard Ellgass
    • , Rudolf Herzog
    • , Uli Binder
    • , Günter Wich
    • , Arne Skerra
    • , David Ayares
    • , Alexander Kind
    • , Uwe Schönmann
    • , Franz-Josef Kaup
    • , Christian Hagl
    • , Eckhard Wolf
    • , Nikolai Klymiuk
    • , Paolo Brenner
    •  & Jan-Michael Abicht
  • Letter |

    In mouse macrophages, a range of short and non-ATG-initiated open reading frames that can generate proteins are identified, one of which is shown to be essential for host immunity to enteric mucosal infection and inflammation.

    • Ruaidhrí Jackson
    • , Lina Kroehling
    • , Alexandra Khitun
    • , Will Bailis
    • , Abigail Jarret
    • , Autumn G. York
    • , Omair M. Khan
    • , J. Richard Brewer
    • , Mathias H. Skadow
    • , Coco Duizer
    • , Christian C. D. Harman
    • , Lelina Chang
    • , Piotr Bielecki
    • , Angel G. Solis
    • , Holly R. Steach
    • , Sarah Slavoff
    •  & Richard A. Flavell
  • Letter |

    A small-molecule agonist for the cGAS–STING pathway has systemic activity in a mouse model of colon cancer.

    • Joshi M. Ramanjulu
    • , G. Scott Pesiridis
    • , Jingsong Yang
    • , Nestor Concha
    • , Robert Singhaus
    • , Shu-Yun Zhang
    • , Jean-Luc Tran
    • , Patrick Moore
    • , Stephanie Lehmann
    • , H. Christian Eberl
    • , Marcel Muelbaier
    • , Jessica L. Schneck
    • , Jim Clemens
    • , Michael Adam
    • , John Mehlmann
    • , Joseph Romano
    • , Angel Morales
    • , James Kang
    • , Lara Leister
    • , Todd L. Graybill
    • , Adam K. Charnley
    • , Guosen Ye
    • , Neysa Nevins
    • , Kamelia Behnia
    • , Amaya I. Wolf
    • , Viera Kasparcova
    • , Kelvin Nurse
    • , Liping Wang
    • , Yue Li
    • , Michael Klein
    • , Christopher B. Hopson
    • , Jeffrey Guss
    • , Marcus Bantscheff
    • , Giovanna Bergamini
    • , Michael A. Reilly
    • , Yiqian Lian
    • , Kevin J. Duffy
    • , Jerry Adams
    • , Kevin P. Foley
    • , Peter J. Gough
    • , Robert W. Marquis
    • , James Smothers
    • , Axel Hoos
    •  & John Bertin
  • Letter |

    Orthogonal ribosomes are engineered in which the two subunits are stapled together in a way that limits association with endogenous subunits in cells, enabling the evolution of new functionality in the orthogonal ribosome.

    • Wolfgang H. Schmied
    • , Zakir Tnimov
    • , Chayasith Uttamapinant
    • , Christopher D. Rae
    • , Stephen D. Fried
    •  & Jason W. Chin

Amendments & Corrections

  • Author Correction |

    • Ulrich Riller
    • , Michael H. Poelchau
    • , Auriol S. P. Rae
    • , Felix M. Schulte
    • , Gareth S. Collins
    • , H. Jay Melosh
    • , Richard A. F. Grieve
    • , Joanna V. Morgan
    • , Sean P. S. Gulick
    • , Johanna Lofi
    • , Abdoulaye Diaw
    • , Naoma McCall
    • , David A. Kring
    • , Joanna V. Morgan
    • , Sean P. S. Gulick
    • , Sophie L. Green
    • , Johanna Lofi
    • , Elise Chenot
    • , Gail L. Christeson
    • , Philippe Claeys
    • , Charles S. Cockell
    • , Marco J. L. Coolen
    • , Ludovic Ferrière
    • , Catalina Gebhardt
    • , Kazuhisa Goto
    • , Heather Jones
    • , David A. Kring
    • , Long Xiao
    • , Christopher M. Lowery
    • , Rubén Ocampo-Torres
    • , Ligia Perez-Cruz
    • , Annemarie E. Pickersgill
    • , Michael H. Poelchau
    • , Auriol S. P. Rae
    • , Cornelia Rasmussen
    • , Mario Rebolledo-Vieyra
    • , Ulrich Riller
    • , Honami Sato
    • , Jan Smit
    • , Sonia M. Tikoo-Schantz
    • , Naotaka Tomioka
    • , Michael T. Whalen
    • , Axel Wittmann
    • , Kosei E. Yamaguchi
    • , Jaime Urrutia Fucugauchi
    •  & Timothy J. Bralower
  • Publisher Correction |

    • A. U. Abeysekara
    • , A. Albert
    • , R. Alfaro
    • , C. Alvarez
    • , J. D. Álvarez
    • , R. Arceo
    • , J. C. Arteaga-Velázquez
    • , D. Avila Rojas
    • , H. A. Ayala Solares
    • , E. Belmont-Moreno
    • , S. Y. BenZvi
    • , C. Brisbois
    • , K. S. Caballero-Mora
    • , T. Capistrán
    • , A. Carramiñana
    • , S. Casanova
    • , M. Castillo
    • , U. Cotti
    • , J. Cotzomi
    • , S. Coutiño de León
    • , C. De León
    • , E. De la Fuente
    • , J. C. Díaz-Vélez
    • , S. Dichiara
    • , B. L. Dingus
    • , M. A. DuVernois
    • , R. W. Ellsworth
    • , K. Engel
    • , C. Espinoza
    • , K. Fang
    • , H. Fleischhack
    • , N. Fraija
    • , A. Galván-Gámez
    • , J. A. García-González
    • , F. Garfias
    • , A. González-Muñoz
    • , M. M. González
    • , J. A. Goodman
    • , Z. Hampel-Arias
    • , J. P. Harding
    • , S. Hernandez
    • , J. Hinton
    • , B. Hona
    • , F. Hueyotl-Zahuantitla
    • , C. M. Hui
    • , P. Hüntemeyer
    • , A. Iriarte
    • , A. Jardin-Blicq
    • , V. Joshi
    • , S. Kaufmann
    • , P. Kar
    • , G. J. Kunde
    • , R. J. Lauer
    • , W. H. Lee
    • , H. León Vargas
    • , H. Li
    • , J. T. Linnemann
    • , A. L. Longinotti
    • , G. Luis-Raya
    • , R. López-Coto
    • , K. Malone
    • , S. S. Marinelli
    • , O. Martinez
    • , I. Martinez-Castellanos
    • , J. Martínez-Castro
    • , J. A. Matthews
    • , P. Miranda-Romagnoli
    • , E. Moreno
    • , M. Mostafá
    • , A. Nayerhoda
    • , L. Nellen
    • , M. Newbold
    • , M. U. Nisa
    • , R. Noriega-Papaqui
    • , J. Pretz
    • , E. G. Pérez-Pérez
    • , Z. Ren
    • , C. D. Rho
    • , C. Rivière
    • , D. Rosa-González
    • , M. Rosenberg
    • , E. Ruiz-Velasco
    • , F. Salesa Greus
    • , A. Sandoval
    • , M. Schneider
    • , H. Schoorlemmer
    • , M. Seglar Arroyo
    • , G. Sinnis
    • , A. J. Smith
    • , R. W. Springer
    • , P. Surajbali
    • , I. Taboada
    • , O. Tibolla
    • , K. Tollefson
    • , I. Torres
    • , G. Vianello
    • , L. Villaseñor
    • , T. Weisgarber
    • , F. Werner
    • , S. Westerhoff
    • , J. Wood
    • , T. Yapici
    • , G. Yodh
    • , A. Zepeda
    • , H. Zhang
    •  & H. Zhou

Collections

  • Nature Outline |

    Liver cirrhosis

    Long considered to be permanent, the extensive scarring found in livers with cirrhosis is now thought to be reversible.

  • Career Guide |

    Events Guide 2019

    Conferences remain an essential part of any scientist's life.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing