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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 540 Number 7633 pp315-476

15 December 2016

About the cover

A seahorse at the Lembeh Strait, Sulawesi, Indonesia. Seahorses are prime examples of the exuberance of evolution and are unique amongst bony fish on several counts, including their equine body shape and male brood pouch. An international collaboration reporting in this issue of Nature has determined the genome sequence of a seahorse (Hippocampus comes, the tiger tail seahorse). They find it to be the most rapidly evolving fish genome studied so far. H. comes is among the most commonly traded seahorse species — dried for traditional medicines and live for the aquarium trade — and is on the IUCN Red List as a ‘vulnerable’ species. Analysis of the genomic sequence provides insights into the evolution of its unique morphology. Of note is the absence of a master control gene, tbx4, which functions in the development of hindlimbs and pelvic fins. Pelvic fins are missing in seahorses, and tbx4-knockout mutant zebrafish also lack pelvic fins. Cover: Jeff Rotman/Getty Images

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Insight: Polymers

Insight: Polymers



  • The seahorse genome and the evolution of its specialized morphologyOpen

    • Qiang Lin
    • Shaohua Fan
    • Yanhong Zhang
    • Meng Xu
    • Huixian Zhang
    • Yulan Yang
    • Alison P. Lee
    • Joost M. Woltering
    • Vydianathan Ravi
    • Helen M. Gunter
    • Wei Luo
    • Zexia Gao
    • Zhi Wei Lim
    • Geng Qin
    • Ralf F. Schneider
    • Xin Wang
    • Peiwen Xiong
    • Gang Li
    • Kai Wang
    • Jiumeng Min
    • Chi Zhang
    • Ying Qiu
    • Jie Bai
    • Weiming He
    • Chao Bian
    • Xinhui Zhang
    • Dai Shan
    • Hongyue Qu
    • Ying Sun
    • Qiang Gao
    • Liangmin Huang
    • Qiong Shi
    • Axel Meyer
    • Byrappa Venkatesh

    Here, the genome sequence of the tiger tail seahorse is reported and comparative genomic analyses with other ray-finned fishes are used to explore the genetic basis of the unique morphology and reproductive system of the seahorse.

  • Electric-field-stimulated protein mechanics

    • Doeke R. Hekstra
    • K. Ian White
    • Michael A. Socolich
    • Robert W. Henning
    • Vukica Šrajer
    • Rama Ranganathan

    A new method in which strong electric fields are applied to a protein crystal while collecting time-resolved X-ray diffraction patterns is able to follow the mechanical motions of all the constituent atoms, with implications for molecular biology and drug discovery.


  • Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

    • Neelroop N. Parikshak
    • Vivek Swarup
    • T. Grant Belgard
    • Manuel Irimia
    • Gokul Ramaswami
    • Michael J. Gandal
    • Christopher Hartl
    • Virpi Leppa
    • Luis de la Torre Ubieta
    • Jerry Huang
    • Jennifer K. Lowe
    • Benjamin J. Blencowe
    • Steve Horvath
    • Daniel H. Geschwind

    Gene expression analysis in brain tissue from individuals with and without autism spectrum disorder (ASD) suggests that the transcription factor SOX5 contributes to an ASD-associated reduction in transcriptional differences between brain areas and indicates that common transcriptomic changes occur in different forms of ASD.

  • Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

    • Simon Schwörer
    • Friedrich Becker
    • Christian Feller
    • Ali H. Baig
    • Ute Köber
    • Henriette Henze
    • Johann M. Kraus
    • Beibei Xin
    • André Lechel
    • Daniel B. Lipka
    • Christy S. Varghese
    • Manuel Schmidt
    • Remo Rohs
    • Ruedi Aebersold
    • Kay L. Medina
    • Hans A. Kestler
    • Francesco Neri
    • Julia von Maltzahn
    • Stefan Tümpel
    • K. Lenhard Rudolph

    Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

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  • A 17-gene stemness score for rapid determination of risk in acute leukaemia

    • Stanley W. K. Ng
    • Amanda Mitchell
    • James A. Kennedy
    • Weihsu C. Chen
    • Jessica McLeod
    • Narmin Ibrahimova
    • Andrea Arruda
    • Andreea Popescu
    • Vikas Gupta
    • Aaron D. Schimmer
    • Andre C. Schuh
    • Karen W. Yee
    • Lars Bullinger
    • Tobias Herold
    • Dennis Görlich
    • Thomas Büchner
    • Wolfgang Hiddemann
    • Wolfgang E. Berdel
    • Bernhard Wörmann
    • Meyling Cheok
    • Claude Preudhomme
    • Hervé Dombret
    • Klaus Metzeler
    • Christian Buske
    • Bob Löwenberg
    • Peter J. M. Valk
    • Peter W. Zandstra
    • Mark D. Minden
    • John E. Dick
    • Jean C. Y. Wang

    A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

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    • Jennifer Govero
    • Prabagaran Esakky
    • Suzanne M. Scheaffer
    • Estefania Fernandez
    • Andrea Drury
    • Derek J. Platt
    • Matthew J. Gorman
    • Justin M. Richner
    • Elizabeth A. Caine
    • Vanessa Salazar
    • Kelle H. Moley
    • Michael S. Diamond

    Infection of male mice with Zika virus caused testicular and epididymal damage, reduction in sex hormone levels, destruction of germ and somatic cells in the testis, loss of mature sperm and reduction in fertility.

  • Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

    • Gopal Sapparapu
    • Estefania Fernandez
    • Nurgun Kose
    • Bin Cao
    • Julie M. Fox
    • Robin G. Bombardi
    • Haiyan Zhao
    • Christopher A. Nelson
    • Aubrey L. Bryan
    • Trevor Barnes
    • Edgar Davidson
    • Indira U. Mysorekar
    • Daved H. Fremont
    • Benjamin J. Doranz
    • Michael S. Diamond
    • James E. Crowe

    Monoclonal Zika-virus-neutralizing human antibodies can protect against maternal–fetal transmission, infection and disease.

  • Structure of photosystem II and substrate binding at room temperature

    • Iris D. Young
    • Mohamed Ibrahim
    • Ruchira Chatterjee
    • Sheraz Gul
    • Franklin D. Fuller
    • Sergey Koroidov
    • Aaron S. Brewster
    • Rosalie Tran
    • Roberto Alonso-Mori
    • Thomas Kroll
    • Tara Michels-Clark
    • Hartawan Laksmono
    • Raymond G. Sierra
    • Claudiu A. Stan
    • Rana Hussein
    • Miao Zhang
    • Lacey Douthit
    • Markus Kubin
    • Casper de Lichtenberg
    • Long Vo Pham
    • Håkan Nilsson
    • Mun Hon Cheah
    • Dmitriy Shevela
    • Claudio Saracini
    • Mackenzie A. Bean
    • Ina Seuffert
    • Dimosthenis Sokaras
    • Tsu-Chien Weng
    • Ernest Pastor
    • Clemens Weninger
    • Thomas Fransson
    • Louise Lassalle
    • Philipp Bräuer
    • Pierre Aller
    • Peter T. Docker
    • Babak Andi
    • Allen M. Orville
    • James M. Glownia
    • Silke Nelson
    • Marcin Sikorski
    • Diling Zhu
    • Mark S. Hunter
    • Thomas J. Lane
    • Andy Aquila
    • Jason E. Koglin
    • Joseph Robinson
    • Mengning Liang
    • Sébastien Boutet
    • Artem Y. Lyubimov
    • Monarin Uervirojnangkoorn
    • Nigel W. Moriarty
    • Dorothee Liebschner
    • Pavel V. Afonine
    • David G. Waterman
    • Gwyndaf Evans
    • Philippe Wernet
    • Holger Dobbek
    • William I. Weis
    • Axel T. Brunger
    • Petrus H. Zwart
    • Paul D. Adams
    • Athina Zouni
    • Johannes Messinger
    • Uwe Bergmann
    • Nicholas K. Sauter
    • Jan Kern
    • Vittal K. Yachandra
    • Junko Yano

    The structures of three intermediate states of photosystem II, which is crucial for photosynthesis, have been solved at room temperature, shedding new light on this process.

  • Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

    • Yi Zheng
    • Ling Qin
    • Natalia V. Ortiz Zacarías
    • Henk de Vries
    • Gye Won Han
    • Martin Gustavsson
    • Marta Dabros
    • Chunxia Zhao
    • Robert J. Cherney
    • Percy Carter
    • Dean Stamos
    • Ruben Abagyan
    • Vadim Cherezov
    • Raymond C. Stevens
    • Adriaan P. IJzerman
    • Laura H. Heitman
    • Andrew Tebben
    • Irina Kufareva
    • Tracy M. Handel

    The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2.

    See also
    See also