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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 540 Number 7632 pp169-308

8 December 2016

About the cover

Iceberg and fjord walls, Scoresby Sund , East Greenland. If the Greenland Ice Sheet were to melt completely, global sea levels would rise dramatically, perhaps by several metres. Two studies published in this issue of Nature, by Joerg Schaefer and colleagues and by Paul Bierman and colleagues, examine the past behaviour of the ice sheet to help evaluate its vulnerability in a warming world. Although analysing the same cosmogenic isotopes, the two groups arrive at seemingly conflicting conclusions. In a News & Views Forum, two geochemists and a glaciologist discuss the issues arising from these papers. Cover: Frans Lanting/National Geographic Creative

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    • Tales of wonder

      A bedtime story can ignite a lifelong love of science. Nature editors riffle through shelves and memories for favourites old and new.






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    • Certified randomness in quantum physics

      • Antonio Acín
      • Lluis Masanes

      Quantum technology enables new methods for generating of randomness with minimal assumptions, certified by the violation of a Bell inequality, which opens up new theoretical and experimental research directions and leads to new challenges.

    • Safeguarding pollinators and their values to human well-being

      • Simon G. Potts
      • Vera Imperatriz-Fonseca
      • Hien T. Ngo
      • Marcelo A. Aizen
      • Jacobus C. Biesmeijer
      • Thomas D. Breeze
      • Lynn V. Dicks
      • Lucas A. Garibaldi
      • Rosemary Hill
      • Josef Settele
      • Adam J. Vanbergen

      Wild and managed pollinators are threatened by pressures such as environmental changes and pesticides, leading to risks for pollinator-dependent crop production, meaning more research and better policies are needed to safeguard pollinators and their services.


    • Gamma frequency entrainment attenuates amyloid load and modifies microglia

      • Hannah F. Iaccarino
      • Annabelle C. Singer
      • Anthony J. Martorell
      • Andrii Rudenko
      • Fan Gao
      • Tyler Z. Gillingham
      • Hansruedi Mathys
      • Jinsoo Seo
      • Oleg Kritskiy
      • Fatema Abdurrob
      • Chinnakkaruppan Adaikkan
      • Rebecca G. Canter
      • Richard Rueda
      • Emery N. Brown
      • Edward S. Boyden
      • Li-Huei Tsai

      Mouse models of Alzheimer’s disease show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline; driving neurons to oscillate at gamma frequency (40 Hz) reduces levels of amyloid-β peptides.

      See also
    • S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

      • Petros A. Tyrakis
      • Asis Palazon
      • David Macias
      • Kian. L. Lee
      • Anthony. T. Phan
      • Pedro Veliça
      • Jia You
      • Grace S. Chia
      • Jingwei Sim
      • Andrew Doedens
      • Alice Abelanet
      • Colin E. Evans
      • John R. Griffiths
      • Lorenz Poellinger
      • Ananda W. Goldrath
      • Randall S. Johnson

      S-2-hydroxyglutarate produced by CD8+ T cells under hypoxic conditions affects locus-specific histone and DNA methylation patterns, which enhances T-cell proliferation, survival and recall responses.

    • m6A modulates neuronal functions and sex determination in Drosophila

      • Tina Lence
      • Junaid Akhtar
      • Marc Bayer
      • Katharina Schmid
      • Laura Spindler
      • Cheuk Hei Ho
      • Nastasja Kreim
      • Miguel A. Andrade-Navarro
      • Burkhard Poeck
      • Mark Helm
      • Jean-Yves Roignant

      One of the most abundant modifications found in messenger RNAs is N6-methyladenosine (m6A); here, this modification is shown to alter gene expression during sex determination and affect neuronal functions and behaviour in Drosophila via the m6A reader protein YT521-B.

      See also


    • Land-use intensification causes multitrophic homogenization of grassland communities

      • Martin M. Gossner
      • Thomas M. Lewinsohn
      • Tiemo Kahl
      • Fabrice Grassein
      • Steffen Boch
      • Daniel Prati
      • Klaus Birkhofer
      • Swen C. Renner
      • Johannes Sikorski
      • Tesfaye Wubet
      • Hartmut Arndt
      • Vanessa Baumgartner
      • Stefan Blaser
      • Nico Blüthgen
      • Carmen Börschig
      • Francois Buscot
      • Tim Diekötter
      • Leonardo Ré Jorge
      • Kirsten Jung
      • Alexander C. Keyel
      • Alexandra-Maria Klein
      • Sandra Klemmer
      • Jochen Krauss
      • Markus Lange
      • Jörg Müller
      • Jörg Overmann
      • Esther Pašalić
      • Caterina Penone
      • David J. Perović
      • Oliver Purschke
      • Peter Schall
      • Stephanie A. Socher
      • Ilja Sonnemann
      • Marco Tschapka
      • Teja Tscharntke
      • Manfred Türke
      • Paul Christiaan Venter
      • Christiane N. Weiner
      • Michael Werner
      • Volkmar Wolters
      • Susanne Wurst
      • Catrin Westphal
      • Markus Fischer
      • Wolfgang W. Weisser
      • Eric Allan

      Analysis of a large grassland biodiversity dataset shows that increases in local land-use intensity cause biotic homogenization at landscape scale across microbial, plant and animal groups, both above- and belowground, that is largely independent of changes in local diversity.

    • Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

      • Eunju Kang
      • Jun Wu
      • Nuria Marti Gutierrez
      • Amy Koski
      • Rebecca Tippner-Hedges
      • Karen Agaronyan
      • Aida Platero-Luengo
      • Paloma Martinez-Redondo
      • Hong Ma
      • Yeonmi Lee
      • Tomonari Hayama
      • Crystal Van Dyken
      • Xinjian Wang
      • Shiyu Luo
      • Riffat Ahmed
      • Ying Li
      • Dongmei Ji
      • Refik Kayali
      • Cengiz Cinnioglu
      • Susan Olson
      • Jeffrey Jensen
      • David Battaglia
      • David Lee
      • Diana Wu
      • Taosheng Huang
      • Don P. Wolf
      • Dmitry Temiakov
      • Juan Carlos Izpisua Belmonte
      • Paula Amato
      • Shoukhrat Mitalipov

      Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

      See also
    • Microcins mediate competition among Enterobacteriaceae in the inflamed gut

      • Martina Sassone-Corsi
      • Sean-Paul Nuccio
      • Henry Liu
      • Dulcemaria Hernandez
      • Christine T. Vu
      • Amy A. Takahashi
      • Robert A. Edwards
      • Manuela Raffatellu

      Certain commensal enterobacteria secrete small proteins called microcins that suppress the growth of other bacteria in the inflamed gut, conferring an intra- and interspecies competitive advantage.

    • Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

      • Erica N. Borducchi
      • Crystal Cabral
      • Kathryn E. Stephenson
      • Jinyan Liu
      • Peter Abbink
      • David Ng’ang’a
      • Joseph P. Nkolola
      • Amanda L. Brinkman
      • Lauren Peter
      • Benjamin C. Lee
      • Jessica Jimenez
      • David Jetton
      • Jade Mondesir
      • Shanell Mojta
      • Abishek Chandrashekar
      • Katherine Molloy
      • Galit Alter
      • Jeffrey M. Gerold
      • Alison L. Hill
      • Mark G. Lewis
      • Maria G. Pau
      • Hanneke Schuitemaker
      • Joseph Hesselgesser
      • Romas Geleziunas
      • Jerome H. Kim
      • Merlin L. Robb
      • Nelson L. Michael
      • Dan H. Barouch

      A combination of therapeutic vaccination with Ad26/MVA and stimulation of innate immune responses leads to improved virologic control and delayed rebound in SIV-infected macaques following discontinuation of antiretroviral therapy.

    • Capturing pairwise and multi-way chromosomal conformations using chromosomal walks

      • Pedro Olivares-Chauvet
      • Zohar Mukamel
      • Aviezer Lifshitz
      • Omer Schwartzman
      • Noa Oded Elkayam
      • Yaniv Lubling
      • Gintaras Deikus
      • Robert P. Sebra
      • Amos Tanay

      A conformation capture sequencing method is developed to link multiple genomic loci into three-dimensional proximity chains called chromosomal walks (C-walks), adding to our understanding of how higher-order chromosomal structures participate in genome regulation.