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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 540 Number 7632 pp169-308

8 December 2016

About the cover

Iceberg and fjord walls, Scoresby Sund , East Greenland. If the Greenland Ice Sheet were to melt completely, global sea levels would rise dramatically, perhaps by several metres. Two studies published in this issue of Nature, by Joerg Schaefer and colleagues and by Paul Bierman and colleagues, examine the past behaviour of the ice sheet to help evaluate its vulnerability in a warming world. Although analysing the same cosmogenic isotopes, the two groups arrive at seemingly conflicting conclusions. In a News & Views Forum, two geochemists and a glaciologist discuss the issues arising from these papers. Cover: Frans Lanting/National Geographic Creative

This Week

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      Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

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      A conformation capture sequencing method is developed to link multiple genomic loci into three-dimensional proximity chains called chromosomal walks (C-walks), adding to our understanding of how higher-order chromosomal structures participate in genome regulation.