This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 556 Number 7699 pp5-135

5 April 2018

About the cover

The cover depicts a scanning electron microscope image of quantum-well infrared photodetectors created from a metamaterial array of metallic resonators. Technologies for the detection of infrared radiation in the long-wavelength range (8-12 micrometres) exist, but devices that are both very fast and sensitive require low-temperature operation, which limits their applications. In this issue, Daniele Palaferri and his collaborators show how photonic metamaterial ideas combined with the high speed of quantum-well infrared photodetectors leads to an ultrasensitive coherent detection, similar to that developed for radio waves: heterodyne detection. This enhanced sensitivity for the detection of long-wavelength infrared radiation at room temperature potentially opens up a range of applications, from thermal imaging and environmental remote sensing to coherent free-space communications. Cover image: Daniele Palaferri & Stephane Suffit/University Paris-Diderot

This Week



World View


Research Highlights


News in Focus


Books and Arts








Brief Communications Arising

  • Lens regeneration in children

    • Demetrios G. Vavvas
    • Thaddeus P. Dryja
    • M. Edward Wilson
    • Timothy W. Olsen
    • Ankoor Shah
    • Ula Jurkunas
    • Roberto Pineda
    • Vasiliki Poulaki
    • Sotiria Palioura
    • Peter Veldman
    • Javier Moreno-Montañés
    • Maria D. Pinazo-Duran
    • José Carlos Pastor
    • Miltiadis Tsilimbaris
    • Douglas Rhee
    • Kathryn Colby
    • David G. Hunter
    • Solon Thanos
    • Taiji Sakamoto
    • Louis R. Pasquale
    • Joan W. Miller
    • Deborah VanderVeen
    • Scott R. Lambert
  • Liu et al. reply

    • Yizhi Liu
    • David Granet
    • Haotian Lin
    • Sally Baxter
    • Hong Ouyang
    • Jie Zhu
    • Shan Huang
    • Zhenzhen Liu
    • Xiaokang Wu
    • Fangbing Yan
    • Xialin Liu
    • Lixia Luo
    • Christopher Heichel
    • Meixia Zhang
    • Wenjia Cai
    • Richard L. Maas
    • Kang Zhang

News & Views



  • The logic of single-cell projections from visual cortex

    • Yunyun Han
    • Justus M. Kebschull
    • Robert A. A. Campbell
    • Devon Cowan
    • Fabia Imhof
    • Anthony M. Zador
    • Thomas D. Mrsic-Flogel

    Tracing of projection neuron axons from the primary visual cortex to their targets shows that these neurons often project to multiple cortical areas of the mouse brain.

  • Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

    • Johnny H. Hu
    • Shannon M. Miller
    • Maarten H. Geurts
    • Weixin Tang
    • Liwei Chen
    • Ning Sun
    • Christina M. Zeina
    • Xue Gao
    • Holly A. Rees
    • Zhi Lin
    • David R. Liu

    Phage-assisted continuous evolution of Cas9 variants with broad PAM compatibility and high DNA specificity that can be used for transcriptional activation, gene disruption and base editing.

  • Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

    • Kuang Shen
    • Rick K. Huang
    • Edward J. Brignole
    • Kendall J. Condon
    • Max L. Valenstein
    • Lynne Chantranupong
    • Aimaiti Bomaliyamu
    • Abigail Choe
    • Chuan Hong
    • Zhiheng Yu
    • David M. Sabatini

    Cryo-electron microscopy and biochemical analyses of the GATOR1 protein complex reveal that two binding modes underpin its ability to regulate Rag GTPases as a GTPase-activating protein for RAGA.


  • Quantized Majorana conductance

    • Hao Zhang
    • Chun-Xiao Liu
    • Sasa Gazibegovic
    • Di Xu
    • John A. Logan
    • Guanzhong Wang
    • Nick van Loo
    • Jouri D. S. Bommer
    • Michiel W. A. de Moor
    • Diana Car
    • Roy L. M. Op het Veld
    • Petrus J. van Veldhoven
    • Sebastian Koelling
    • Marcel A. Verheijen
    • Mihir Pendharkar
    • Daniel J. Pennachio
    • Borzoyeh Shojaei
    • Joon Sue Lee
    • Chris J. Palmstrøm
    • Erik P. A. M. Bakkers
    • S. Das Sarma
    • Leo P. Kouwenhoven

    In a step towards topological quantum computation, a quantized Majorana conductance has been demonstrated for a semiconducting nanowire coupled to a superconductor.

  • Correlated insulator behaviour at half-filling in magic-angle graphene superlattices

    • Yuan Cao
    • Valla Fatemi
    • Ahmet Demir
    • Shiang Fang
    • Spencer L. Tomarken
    • Jason Y. Luo
    • Javier D. Sanchez-Yamagishi
    • Kenji Watanabe
    • Takashi Taniguchi
    • Efthimios Kaxiras
    • Ray C. Ashoori
    • Pablo Jarillo-Herrero

    When the two graphene sheets in a van der Waals heterostructure are twisted relative to each other by a specific amount, Mott-like insulating phases are observed at half-filling.

  • Room-temperature nine-µm-wavelength photodetectors and GHz-frequency heterodyne receivers

    • Daniele Palaferri
    • Yanko Todorov
    • Azzurra Bigioli
    • Alireza Mottaghizadeh
    • Djamal Gacemi
    • Allegra Calabrese
    • Angela Vasanelli
    • Lianhe Li
    • A. Giles Davies
    • Edmund H. Linfield
    • Filippos Kapsalidis
    • Mattias Beck
    • Jérôme Faist
    • Carlo Sirtori

    Quantum-well photodetectors fabricated from photonic metamaterials show enhanced room-temperature sensitivity to long-wavelength infrared radiation and produce gigahertz-frequency heterodyne signals when pumped with quantum cascade lasers.

  • Molecular nucleation mechanisms and control strategies for crystal polymorph selection

    • Alexander E. S. Van Driessche
    • Nani Van Gerven
    • Paul H. H. Bomans
    • Rick R. M. Joosten
    • Heiner Friedrich
    • David Gil-Carton
    • Nico A. J. M. Sommerdijk
    • Mike Sleutel

    Cryo-transmission electron microscopy reveals the initiation of glucose isomerase crystals and their growth into different crystalline or gel polymorphs, and shows that mutating specific amino acids controls which polymorph grows.

  • Climatic control of Mississippi River flood hazard amplified by river engineering

    • Samuel E. Munoz
    • Liviu Giosan
    • Matthew D. Therrell
    • Jonathan W. F. Remo
    • Zhixiong Shen
    • Richard M. Sullivan
    • Charlotte Wiman
    • Michelle O’Donnell
    • Jeffrey P. Donnelly

    A suite of river discharge, tree-ring, sedimentary and climate data shows that the Mississippi’s flood magnitude has risen by about twenty per cent over the past half-century, largely owing to engineering works.

  • A new class of synthetic retinoid antibiotics effective against bacterial persisters

    • Wooseong Kim
    • Wenpeng Zhu
    • Gabriel Lambert Hendricks
    • Daria Van Tyne
    • Andrew D. Steele
    • Colleen E. Keohane
    • Nico Fricke
    • Annie L. Conery
    • Steven Shen
    • Wen Pan
    • Kiho Lee
    • Rajmohan Rajamuthiah
    • Beth Burgwyn Fuchs
    • Petia M. Vlahovska
    • William M. Wuest
    • Michael S. Gilmore
    • Huajian Gao
    • Frederick M. Ausubel
    • Eleftherios Mylonakis

    Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of chronic MRSA infection.

  • Whole-organism clone tracing using single-cell sequencing

    • Anna Alemany
    • Maria Florescu
    • Chloé S. Baron
    • Josi Peterson-Maduro
    • Alexander van Oudenaarden

    A single-cell sequencing method is developed that uses transcriptomics and CRISPR–Cas9 technology to investigate clonal relationships in cells present in different zebrafish tissues.

  • Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

    • Evanna L. Mills
    • Dylan G. Ryan
    • Hiran A. Prag
    • Dina Dikovskaya
    • Deepthi Menon
    • Zbigniew Zaslona
    • Mark P. Jedrychowski
    • Ana S. H. Costa
    • Maureen Higgins
    • Emily Hams
    • John Szpyt
    • Marah C. Runtsch
    • Martin S. King
    • Joanna F. McGouran
    • Roman Fischer
    • Benedikt M. Kessler
    • Anne F. McGettrick
    • Mark M. Hughes
    • Richard G. Carroll
    • Lee M. Booty
    • Elena V. Knatko
    • Paul J. Meakin
    • Michael L. J. Ashford
    • Louise K. Modis
    • Gino Brunori
    • Daniel C. Sévin
    • Padraic G. Fallon
    • Stuart T. Caldwell
    • Edmund R. S. Kunji
    • Edward T. Chouchani
    • Christian Frezza
    • Albena T. Dinkova-Kostova
    • Richard C. Hartley
    • Michael P. Murphy
    • Luke A. O’Neill

    WebTreatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory transcription factor Nrf2 by alkylating key cysteine residues on the KEAP1 protein.

  • Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

    • Megan Sjodt
    • Kelly Brock
    • Genevieve Dobihal
    • Patricia D. A. Rohs
    • Anna G. Green
    • Thomas A. Hopf
    • Alexander J. Meeske
    • Veerasak Srisuknimit
    • Daniel Kahne
    • Suzanne Walker
    • Debora S. Marks
    • Thomas G. Bernhardt
    • David Z. Rudner
    • Andrew C. Kruse

    Evolutionary coupling-enabled molecular replacement determination of the structure of Thermus thermophilus RodA reveals a highly conserved cavity in its transmembrane domain, and mutagenesis experiments in Bacillus subtilis and Escherichia coli show that perturbation of this cavity abolishes RodA function.

  • Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

    • Giovanna Scapin
    • Venkata P. Dandey
    • Zhening Zhang
    • Winifred Prosise
    • Alan Hruza
    • Theresa Kelly
    • Todd Mayhood
    • Corey Strickland
    • Clinton S. Potter
    • Bridget Carragher

    Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.

  • Modular assembly of the nucleolar pre-60S ribosomal subunit

    • Zahra Assur Sanghai
    • Linamarie Miller
    • Kelly R. Molloy
    • Jonas Barandun
    • Mirjam Hunziker
    • Malik Chaker-Margot
    • Junjie Wang
    • Brian T. Chait
    • Sebastian Klinge

    Cryo-electron microscopy structures of multiple states along the assembly pathway of the nucleolar pre-60S ribosomal subunit suggest that folding of the pre-ribosomal RNA and sequential binding of transient assembly factors are regulated by steric hindrance among these factors.